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PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2 [ Homo sapiens (human) ]

Gene ID: 5161, updated on 5-Jul-2015
Official Symbol
PDHA2provided by HGNC
Official Full Name
pyruvate dehydrogenase (lipoamide) alpha 2provided by HGNC
Primary source
HGNC:HGNC:8807
See related
Ensembl:ENSG00000163114; HPRD:01531; MIM:179061; Vega:OTTHUMG00000130990
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDHAL
Orthologs
See PDHA2 in Epigenomics, MapViewer
Location:
4q22-q23
Exon count:
1
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (95840088..95841474)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (96761239..96762625)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377337 Neighboring gene ribosomal protein L30 pseudogene 6 Neighboring gene uncharacterized LOC105377338 Neighboring gene RNA, U6 small nuclear 34, pseudogene Neighboring gene talin 2 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC149517, MGC149518

Gene Ontology Provided by GOA

Function Evidence Code Pubs
pyruvate dehydrogenase (acetyl-transferring) activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acetyl-CoA biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
glycolytic process IEA
Inferred from Electronic Annotation
more info
 
pyruvate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
pyruvate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
Names
PDHE1-A type II
pyruvate dehydrogenase, E1-alpha polypeptide, testis specific
NP_005381.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005390.4NP_005381.1  pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial precursor

    See identical proteins and their annotated locations for NP_005381.1

    Status: VALIDATED

    Source sequence(s)
    AC093828, BC030697
    Consensus CDS
    CCDS3644.1
    UniProtKB/Swiss-Prot
    P29803
    Related
    ENSP00000295266, OTTHUMP00000161620, ENST00000295266, OTTHUMT00000253608
    Conserved Domains (1) summary
    cd02000
    Location:62351
    TPP_E1_PDC_ADC_BCADC; Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    95840088..95841474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    96737910..96739296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)