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    LSR lipolysis stimulated lipoprotein receptor [ Homo sapiens ]

    Gene ID: 51599, updated on 14-May-2012
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    Summary

    Official Symbol
    LSRprovided by HGNC
    Official Full Name
    lipolysis stimulated lipoprotein receptorprovided by HGNC
    Primary source
    HGNC:29572
    See related
    Ensembl:ENSG00000105699; HPRD:17283
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ILDR3; LISCH7; MGC10659; MGC48312; MGC48503
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    Genomic context

    Location :
    19q13.12
    Sequence :
    Chromosome: 19; NC_000019.9 (35739559..35758867)
    See LSR in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 187, member B Neighboring gene family with sequence similarity 187, member B pseudogene Neighboring gene upstream transcription factor 2, c-fos interacting Neighboring gene hepcidin antimicrobial peptide

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Identification of the cellular receptor of Clostridium spiroforme toxin. Papatheodorou P, et al. Infect Immun, 2012 Apr. PMID 22252869.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. LSR defines cell corners for tricellular tight junction formation in epithelial cells. Masuda S, et al. J Cell Sci, 2011 Feb 15. PMID 21245199.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. findings show that Clostridium spiroforme toxin (CST)enters target cells via the lipolysis-stimulated lipoprotein receptor; findings indicate that CST shares LSR with C. difficile CDT and C. perfringens iota toxin as a host cell surface receptor
      Title: Identification of the cellular receptor of Clostridium spiroforme toxin.
    2. LSR defines tricellular contacts in epithelial cellular sheets by acting as a landmark to recruit tricellulin for tricellular tight junction formation.
      Title: LSR defines cell corners for tricellular tight junction formation in epithelial cells.
    3. LISCH7 may have a role in progression of human colon cancer
      Title: Prognostic value of LISCH7 mRNA in plasma and tumor of colon cancer patients.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q86X29 P61981 YWHAG    HPRD  PubMed  
    BioGRID:119629 BioGRID:109072 SFN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119629 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119629 BioGRID:113361 YWHAB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119629 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    embryo development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    liver development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    chylomicron IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    very-low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    lipolysis-stimulated lipoprotein receptor
    Names
    lipolysis-stimulated lipoprotein receptor
    LISCH protein
    lipolysis-stimulated remnant
    liver-specific bHLH-Zip transcription factor
    immunoglobulin-like domain containing receptor 3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001260489.1 → NP_001247418.1  lipolysis-stimulated lipoprotein receptor isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AK126834, BM837160, BM971691, CF141732

    2. NM_001260490.1 → NP_001247419.1  lipolysis-stimulated lipoprotein receptor isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AK126834, AK296618, BM837160, BM971691

    3. NM_015925.6 → NP_057009.3  lipolysis-stimulated lipoprotein receptor isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK126834, BC004381, BM837160, BM971691
      Consensus CDS
      CCDS12449.1
      UniProtKB/TrEMBL
      E9PHD4
      UniProtKB/Swiss-Prot
      Q86X29
      UniProtKB/TrEMBL
      Q9BT33
      UniProtKB/TrEMBL
      Q9BWS2
      Related
      ENSP00000346976, ENST00000354900

    4. NM_205834.3 → NP_991403.1  lipolysis-stimulated lipoprotein receptor isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
      Source sequence(s)
      AK126834, BC047376, BM971691
      Consensus CDS
      CCDS12450.1
      UniProtKB/Swiss-Prot
      Q86X29
      UniProtKB/TrEMBL
      Q9BT33
      Related
      ENSP00000354575, ENST00000361790

    5. NM_205835.3 → NP_991404.1  lipolysis-stimulated lipoprotein receptor isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AK126834, AK130367, BM837160, BM971691
      Consensus CDS
      CCDS12451.1
      UniProtKB/TrEMBL
      A6NDW3
      UniProtKB/Swiss-Prot
      Q86X29
      UniProtKB/TrEMBL
      Q9BT33
      Related
      ENSP00000354034, ENST00000360798

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      35739559..35758867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      32248032..32267353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC002128.1 AAB58317.1
    genomic AD000684.1 AAB51178.1
    genomic JA738591.1 CCF76948.1
    genomic JA738593.1 CCF76949.1
    genomic JA738595.1 CCF76950.1
    mRNA AF130366.1 AAD22101.1
    mRNA AK075426.1 BAC11614.1
    mRNA AK126834.1 BAC86714.1
    mRNA AK130367.1 None
    mRNA AK296618.1 BAG59226.1
    mRNA BC000015.2 AAH00015.2
    mRNA BC004381.1 AAH04381.2
    mRNA BC047376.1 AAH47376.2
    mRNA BM837160.1 None
    mRNA BM971691.1 None
    mRNA BQ711340.1 None
    mRNA CF141732.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86X29.4 GenPept UniProtKB/Swiss-Prot:Q86X29
    Q8NBM0 GenPept UniProtKB/TrEMBL:Q8NBM0
    Q9BT33 GenPept UniProtKB/TrEMBL:Q9BT33
    Q9BWS2 GenPept UniProtKB/TrEMBL:Q9BWS2
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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