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    MED15 mediator complex subunit 15 [ Homo sapiens ]

    Gene ID: 51586, updated on 11-May-2012
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    Summary

    Official Symbol
    MED15provided by HGNC
    Official Full Name
    mediator complex subunit 15provided by HGNC
    Primary source
    HGNC:14248
    See related
    Ensembl:ENSG00000099917; HPRD:12117; MIM:607372; Vega:OTTHUMG00000150810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIG1; CAG7A; CTG7A; PCQAP; TIG-1; TNRC7; ARC105; FLJ42282; FLJ42935; DKFZp686A2214; DKFZp762B1216
    Summary
    The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    22q11.2
    Sequence :
    Chromosome: 22; NC_000022.10 (20861886..20941919)
    See MED15 in Epigenomics, MapViewer

    Chromosome 22 - NC_000022.10Genomic Context describing neighboring genes Neighboring gene kelch-like 12 (Drosophila) pseudogene Neighboring gene kelch-like 22 (Drosophila) Neighboring gene keratin 18 pseudogene 5 Neighboring gene sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) pseudogene 1 Neighboring gene immunoglobulin lambda-like polypeptide 4, pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    2. Activator-Mediator binding regulates Mediator-cofactor interactions. Ebmeier CC, et al. Proc Natl Acad Sci U S A, 2010 Jun 22. PMID 20534441.
    3. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. Krebs AR, et al. EMBO Rep, 2010 Jul. PMID 20508642.
    4. Streamlined analysis schema for high-throughput identification of endogenous protein complexes. Malovannaya A, et al. Proc Natl Acad Sci U S A, 2010 Feb 9. PMID 20133760.
    5. CDK8 is a positive regulator of transcriptional elongation within the serum response network. Donner AJ, et al. Nat Struct Mol Biol, 2010 Feb. PMID 20098423.

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The data identify PC2 as a novel PLAGL2-binding protein and important mediator of PLAGL2 transactivation.
      Title: Modulation of PLAGL2 transactivation by positive cofactor 2 (PC2), a component of the ARC/Mediator complex.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: An association study of PCQAP polymorphisms and schizophrenia.
    3. SREBPs use the evolutionarily conserved ARC105 (also called MED15) subunit to activate target genes
      Title: An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.
    4. Limited role of exon 7 PCQAP polymorphisms in the pathogenesis of schizophrenia.
      Title: An association study of PCQAP polymorphisms and schizophrenia.
    5. TIG1 gene Silencing by promoter hypermethylation is associated with nasopharyngeal carcinoma
      Title: Silencing of the retinoid response gene TIG1 by promoter hypermethylation in nasopharyngeal carcinoma.
    6. Methylation of TIG1 in prostatic neoplasms correlates with methylation of the retinoic acid receptor beta gene.
      Title: Methylation of the retinoid response gene TIG1 in prostate cancer correlates with methylation of the retinoic acid receptor beta gene.
    7. results suggest that TRIM11, with the ubiquitin-proteasome pathway, regulates ARC105 function in TGFbeta signaling
      Title: TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system.
    8. The protein encoded by this gene was identified as ARC105, a 105kDa component of the Activator-Recruited Cofactor (ARC) that is involved in mediating gene activation by several classes of transcriptional regulators.
      Title: Composite co-activator ARC mediates chromatin-directed transcriptional activation.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q96RN5 P36542 ATP5C1    HPRD  PubMed  
    Q96RN5 P54253 ATXN1    HPRD  PubMed  
    Q96RN5 Q13643 FHL3    HPRD  PubMed  
    Q96RN5 Mediator of RNA polymerase II transcription subunit 25 homolog MED25    HPRD  PubMed  
    Q96RN5 P55198 MLLT6    HPRD  PubMed  
    Q96RN5 O15162 PLSCR1    HPRD  PubMed  
    Q96RN5 Q15796 SMAD2    HPRD  PubMed  
    Q96RN5 P84022 SMAD3    HPRD  PubMed  
    Q96RN5 Q96F44 TRIM11    HPRD  PubMed  
    Q96RN5 P62988 UBB    HPRD  PubMed  
    BioGRID:119623 BioGRID:106997 ATP5C1    BioGRID  PubMed Two-hybrid 
    BioGRID:119623 BioGRID:107458 CDK8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:114597 CTDP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119623 BioGRID:108566 FHL3    BioGRID  PubMed Two-hybrid 
    BioGRID:119623 BioGRID:111465 MED1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:119623 BioGRID:123974 MED10    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:119623 BioGRID:115293 MED12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:115294 MED13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:114699 MED14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:115342 MED16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:114830 MED17    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:120156 MED18    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:128553 MED19    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:114829 MED23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:123607 MED25    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:119623 BioGRID:114831 MED26    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:123219 MED28    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:120734 MED29    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:115319 MED6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:114833 MED7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:120403 MED9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:110448 MLLT6    BioGRID  PubMed Two-hybrid 
    BioGRID:119623 BioGRID:111373 PLSCR1    BioGRID  PubMed Two-hybrid 
    BioGRID:119623 BioGRID:114834 QKI    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:111902 RELA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119623 BioGRID:110261 SMAD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119623 BioGRID:110262 SMAD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119623 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119623 BioGRID:112598 SREBF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-localization; Reconstituted Complex 
    BioGRID:119623 BioGRID:112734 TADA2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:123523 TRIM11    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:119623 BioGRID:114735 TRIP4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:113900 TRRAP    BioGRID  PubMed Co-purification 
    BioGRID:119623 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:119623 BioGRID:971443 UL48    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119623 BioGRID:116719 ZC3H13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119623 BioGRID:41755 sbp-1    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
      Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • PPARA Activates Gene Expression, organism-specific biosystem (from REACTOME)
      PPARA Activates Gene Expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
    • Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
      Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
    • Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
      Regulation of nuclear SMAD2/3 signaling
    • Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA polymerase II transcription cofactor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 15
    Names
    mediator of RNA polymerase II transcription subunit 15
    TPA inducible gene-1
    CTG repeat protein 7a
    TPA inducible protein
    TPA-inducible gene 1 protein
    trinucleotide repeat containing 7
    activator-recruited cofactor, 105-kD
    PC2-glutamine-rich-associated protein
    PC2 glutamine/Q-rich-associated protein
    activator-recruited cofactor 105 kDa component
    trinucleotide repeat-containing gene 7 protein
    positive cofactor 2 glutamine/Q-rich-associated protein
    positive cofactor 2, glutamine/Q-rich-associated protein
    PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003891.1 → NP_001003891.1  mediator of RNA polymerase II transcription subunit 15 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AW245653, BC013985, BC017110, CB988805
      Consensus CDS
      CCDS33602.1
      UniProtKB/Swiss-Prot
      Q96RN5
      Related
      ENSP00000263205, OTTHUMP00000198545, ENST00000263205, OTTHUMT00000320177
      Conserved Domains (1) summary
      pfam09606
      Location:493 – 784
      Blast Score: 891
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    2. NM_015889.3 → NP_056973.2  mediator of RNA polymerase II transcription subunit 15 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AF056191, AW245653, BC013985, BX478424
      Consensus CDS
      CCDS13781.1
      UniProtKB/Swiss-Prot
      Q96RN5
      Related
      ENSP00000292733, OTTHUMP00000198544, ENST00000292733, OTTHUMT00000320174
      Conserved Domains (1) summary
      pfam09606
      Location:453 – 744
      Blast Score: 910
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000022.10 Reference GRCh37.p5 Primary Assembly

      Range
      20861886..20941919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000154.1 Alternate HuRef

      Range
      4129649..4209632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC004033.3 (78509..89225) None
    genomic AC005500.2 (177555..192591) None
    genomic AC007050.25 None
    genomic AC007731.16 (164062..182616) None
    genomic CH471176.2 EAX02948.1
      EAX02949.1
      EAX02950.1
      EAX02951.1
      EAX02952.1
      EAX02953.1
      EAX02954.1
      EAX02955.1
      EAX02956.1
    mRNA AF056191.1 AAC12944.1
    mRNA AF328769.1 AAK58423.1
    mRNA AK000003.1 BAA92228.1
    mRNA AK074230.1 None
    mRNA AK074268.1 BAB85034.1
    mRNA AK090465.1 BAC03446.1
    mRNA AK124276.1 BAG54024.1
    mRNA AK124925.1 BAG54113.1
    mRNA AK126208.1 None
    mRNA AK294540.1 BAG57747.1
    mRNA AK294734.1 BAH11863.1
    mRNA AK297284.1 BAG59755.1
    mRNA AK297789.1 BAG60130.1
    mRNA AK315540.1 None
    mRNA AL832923.1 CAH10623.1
    mRNA AW245653.1 None
    mRNA BC003078.1 AAH03078.1
    mRNA BC005027.1 None
    mRNA BC007529.1 AAH07529.1
    mRNA BC013985.2 AAH13985.1
    mRNA BC017110.1 None
    mRNA BX478424.1 None
    mRNA CB988805.1 None
    mRNA CR456537.1 CAG30423.1
    mRNA U80745.1 AAB91443.1
    mRNA AL832151.1 CAH10580.1
    other-genetic CU013137.1 CAK54568.1
    other-genetic CU013425.1 CAK54867.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69YK5 GenPept UniProtKB/TrEMBL:Q69YK5
    Q69YR4 GenPept UniProtKB/TrEMBL:Q69YR4
    Q6PKB8 GenPept UniProtKB/TrEMBL:Q6PKB8
    Q96RN5.2 GenPept UniProtKB/Swiss-Prot:Q96RN5
    Q9NXY2 GenPept UniProtKB/TrEMBL:Q9NXY2
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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