Format

Send to:

Choose Destination

ARMCX3 armadillo repeat containing, X-linked 3 [ Homo sapiens (human) ]

Gene ID: 51566, updated on 8-May-2016
Official Symbol
ARMCX3provided by HGNC
Official Full Name
armadillo repeat containing, X-linked 3provided by HGNC
Primary source
HGNC:HGNC:24065
See related
Ensembl:ENSG00000102401 HPRD:02294; MIM:300364; Vega:OTTHUMG00000022035
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALEX3; GASP6; dJ545K15.2
Summary
This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
Xq22.1
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (101623127..101627843)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100878117..100882833)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing, X-linked 7, pseudogene Neighboring gene armadillo repeat containing, X-linked 6 Neighboring gene RNA, U6 small nuclear 30, pseudogene Neighboring gene armadillo repeat containing, X-linked 2

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0443, MGC12199, DKFZp781N1954

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
armadillo repeat-containing X-linked protein 3
Names
1200004E24Rik
ARM protein lost in epithelial cancers on chromosome X 3
arm protein lost in epithelial cancers, X chromosome, 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013222.1 RefSeqGene

    Range
    5001..9712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016607.3NP_057691.1  armadillo repeat-containing X-linked protein 3

    See identical proteins and their annotated locations for NP_057691.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    BC005194, BG035798, BM905704, BX647802
    Consensus CDS
    CCDS14489.1
    UniProtKB/Swiss-Prot
    Q9UH62
    UniProtKB/TrEMBL
    A0A024RCF9
    Related
    ENSP00000340672, OTTHUMP00000023688, ENST00000341189, OTTHUMT00000057568
    Conserved Domains (2) summary
    cd00020
    Location:123198
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:110363
    Arm_2; Armadillo-like
  2. NM_177947.2NP_808816.1  armadillo repeat-containing X-linked protein 3

    See identical proteins and their annotated locations for NP_808816.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    BC005194, BG035798, BX647802
    Consensus CDS
    CCDS14489.1
    UniProtKB/Swiss-Prot
    Q9UH62
    UniProtKB/TrEMBL
    A0A024RCF9
    Related
    ENSP00000454483, OTTHUMP00000253882, ENST00000471229, OTTHUMT00000057571
    Conserved Domains (2) summary
    cd00020
    Location:123198
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:110363
    Arm_2; Armadillo-like
  3. NM_177948.2NP_808817.1  armadillo repeat-containing X-linked protein 3

    See identical proteins and their annotated locations for NP_808817.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1, and represents the shortest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    BC005194, BM905704, BX647802, CA397688
    Consensus CDS
    CCDS14489.1
    UniProtKB/Swiss-Prot
    Q9UH62
    UniProtKB/TrEMBL
    A0A024RCF9
    Related
    ENSP00000439032, ENST00000537169
    Conserved Domains (2) summary
    cd00020
    Location:123198
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:110363
    Arm_2; Armadillo-like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    101623127..101627843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262141.1XP_005262198.1  

    See identical proteins and their annotated locations for XP_005262198.1

    UniProtKB/Swiss-Prot
    Q9UH62
    UniProtKB/TrEMBL
    A0A024RCF9
    Conserved Domains (2) summary
    cd00020
    Location:123198
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:110363
    Arm_2; Armadillo-like

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    100771977..100776688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)