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MBIP MAP3K12 binding inhibitory protein 1 [ Homo sapiens (human) ]

Gene ID: 51562, updated on 8-May-2016
Official Symbol
MBIPprovided by HGNC
Official Full Name
MAP3K12 binding inhibitory protein 1provided by HGNC
Primary source
HGNC:HGNC:20427
See related
Ensembl:ENSG00000151332 HPRD:14368; MIM:609431; Vega:OTTHUMG00000140222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Orthologs
Location:
14q13.3
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (36298558..36320676, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (36767764..36789882, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 609 Neighboring gene papillary thyroid carcinoma susceptibility candidate 3 (non-protein coding) Neighboring gene uncharacterized LOC101927199 Neighboring gene uncharacterized LOC102723418 Neighboring gene developmental pluripotency associated 3 pseudogene 2 Neighboring gene uncharacterized LOC105370454 Neighboring gene surfactant associated 3

NHGRI GWAS Catalog

Description
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
NHGRI GWA Catalog
Discovery of common variants associated with low TSH levels and thyroid cancer risk.
NHGRI GWA Catalog
  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • HATs acetylate histones, organism-specific biosystem (from REACTOME)
    HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
inactivation of MAPK activity involved in osmosensory signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Ada2/Gcn5/Ada3 transcription activator complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
MAP3K12-binding inhibitory protein 1
Names
MAPK upstream kinase-binding inhibitory protein
MUK-binding inhibitory protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144891.1NP_001138363.1  MAP3K12-binding inhibitory protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AA761503, AL137226, BC016821
    Consensus CDS
    CCDS45096.1
    UniProtKB/Swiss-Prot
    Q9NS73
    Related
    ENSP00000324444, OTTHUMP00000244269, ENST00000318473, OTTHUMT00000410111
    Conserved Domains (1) summary
    PRK14669
    Location:56166
    uvrC; excinuclease ABC subunit C; Provisional
  2. NM_001308110.1NP_001295039.1  MAP3K12-binding inhibitory protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 3' coding region that results in a frameshift and novel 3' coding region compared to variant 1. It encodes isoform 3, which is shorter than and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA761503, AK315290, BX248287
    Consensus CDS
    CCDS76672.1
    UniProtKB/Swiss-Prot
    Q9NS73
    UniProtKB/TrEMBL
    B2RCV0
    Conserved Domains (1) summary
    PRK14669
    Location:56166
    uvrC; excinuclease ABC subunit C; Provisional
  3. NM_016586.2NP_057670.2  MAP3K12-binding inhibitory protein 1 isoform 1

    See identical proteins and their annotated locations for NP_057670.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA761503, AK315290, AL137226
    Consensus CDS
    CCDS9658.1
    UniProtKB/Swiss-Prot
    Q9NS73
    UniProtKB/TrEMBL
    B2RCV0
    Related
    ENSP00000399718, OTTHUMP00000178844, ENST00000416007, OTTHUMT00000276685
    Conserved Domains (1) summary
    PRK14669
    Location:56166
    uvrC; excinuclease ABC subunit C; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    36298558..36320676 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267754.2XP_005267811.1  

    Conserved Domains (1) summary
    PRK14669
    Location:56166
    uvrC; excinuclease ABC subunit C; Provisional
  2. XM_005267755.2XP_005267812.1  

    Related
    ENSP00000352517, OTTHUMP00000244270, ENST00000359527, OTTHUMT00000410112
    Conserved Domains (1) summary
    PRK14669
    Location:56166
    uvrC; excinuclease ABC subunit C; Provisional
  3. XM_005267756.3XP_005267813.1  

    Related
    ENSP00000474535, OTTHUMP00000244272, ENST00000604336, OTTHUMT00000410117
    Conserved Domains (1) summary
    PRK14669
    Location:56166
    uvrC; excinuclease ABC subunit C; Provisional
  4. XM_011536833.1XP_011535135.1  

    Related
    ENSP00000473739, OTTHUMP00000244271, ENST00000605579, OTTHUMT00000410116
    Conserved Domains (1) summary
    PRK14669
    Location:56166
    uvrC; excinuclease ABC subunit C; Provisional

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    36766890..36789007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)