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ACKR4 atypical chemokine receptor 4 [ Homo sapiens (human) ]

Gene ID: 51554, updated on 12-May-2016
Official Symbol
ACKR4provided by HGNC
Official Full Name
atypical chemokine receptor 4provided by HGNC
Primary source
HGNC:HGNC:1611
See related
Ensembl:ENSG00000129048 HPRD:07298; MIM:606065; Vega:OTTHUMG00000159768
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPR1; CCBP2; CCR10; CCR11; CCRL1; VSHK1; CCR-11; CKR-11; CCX CKR; CCX-CKR; CC-CKR-11
Summary
The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013]
Orthologs
Location:
3q22
Exon count:
2
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (132597237..132602644)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (132316081..132321488)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NIP7, nucleolar pre-rRNA processing protein pseudogene 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C13 Neighboring gene NPHP3-ACAD11 readthrough (NMD candidate) Neighboring gene acyl-CoA dehydrogenase family member 11 Neighboring gene heat shock protein family A (Hsp70) member pseudogene 19 Neighboring gene ubiquitin like modifier activating enzyme 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
NHGRI GWA Catalog
Genetic variation associated with circulating monocyte count in the eMERGE Network.
NHGRI GWA Catalog
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
  • Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
    Chemokine receptors bind chemokines, organism-specific biosystemChemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of i...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemokine binding IEA
Inferred from Electronic Annotation
more info
 
chemokine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
early endosome IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
recycling endosome IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
atypical chemokine receptor 4
Names
C-C CKR-11
C-C chemokine receptor type 11
CC chemokine receptor-like 1
chemocentryx chemokine receptor
chemokine (C-C motif) receptor-like 1
chemokine, cc motif, receptor-like protein 1
orphan seven-transmembrane receptor, chemokine related

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016557.3NP_057641.1  atypical chemokine receptor 4

    See identical proteins and their annotated locations for NP_057641.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, as compared to variant 1. Both variants encode the some protein.
    Source sequence(s)
    AF110640, AK225927, BQ015927, DC419249
    Consensus CDS
    CCDS3075.1
    UniProtKB/Swiss-Prot
    Q9NPB9
    Related
    ENSP00000249887, OTTHUMP00000216426, ENST00000249887, OTTHUMT00000357238
    Conserved Domains (1) summary
    pfam00001
    Location:64303
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_178445.2NP_848540.1  atypical chemokine receptor 4

    See identical proteins and their annotated locations for NP_848540.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, as compared to variant 2. Both variants encode the same protein.
    Source sequence(s)
    AC020632
    Consensus CDS
    CCDS3075.1
    UniProtKB/Swiss-Prot
    Q9NPB9
    Conserved Domains (1) summary
    pfam00001
    Location:64303
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    132597237..132602644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    132279096..132284503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)