CINP cyclin-dependent kinase 2 interacting protein [Homo sapiens] - Gene

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Summary

Official Symbol: CINPprovided by HGNC
Official Full Name: cyclin-dependent kinase 2 interacting proteinprovided by HGNC
Primary source: HGNC:23789
See related: Ensembl:ENSG00000100865; HPRD:16715; MIM:613362; Vega:OTTHUMG00000171775
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MGC849
Summary: The protein encoded by this gene interacts with CDK2, MCM5, and CDC7, and is associated with the origin recognition complex protein ORC2. It acts as a homodimer and is involved in replication and ATR-mediated checkpoint signaling. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

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Genomic context

Location :: 14q32.31

Sequence :: Chromosome: 14; NC_000014.8 (102814619..102829253, complement)

See CINP in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NS5B delays cells in S phase through interaction with CINP and relocalization of the protein from the nucleus to the cytoplasm
Title: Hepatitis C virus NS5B protein delays s phase progression in human hepatocyte-derived cells by relocalizing cyclin-dependent kinase 2-interacting protein (CINP).
CINP interacts with ATR-interacting protein and regulates ATR-dependent signaling, resistance to replication stress, and G2 checkpoint integrity.
Title: Functional genomic screens identify CINP as a genome maintenance protein.
CINP is part of the Cdc7-dependent mechanism of origin firing and a functional and physical link between Cdk2 and Cdc7 complexes at the origins
Title: A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
Cyclin dependent kinase 2 interacting protein	Q96AJ1	CLUAP1		HPRD	PubMed
BioGRID:119604	BioGRID:116694	CLUAP1		BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info

Process	Evidence Code	Pubs
DNA repair	IEA Inferred from Electronic Annotation more info
DNA replication	IEA Inferred from Electronic Annotation more info
cell cycle	IEA Inferred from Electronic Annotation more info
cell division	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: cyclin-dependent kinase 2-interacting protein

Names: cyclin-dependent kinase 2-interacting protein; CDK2-interacting protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177611.1 → NP_001171082.1 cyclin-dependent kinase 2-interacting protein isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AL137229, BC000600, BU174070

Consensus CDS

CCDS53914.1

UniProtKB/TrEMBL

F5H8A7

UniProtKB/Swiss-Prot

Q9BW66

Related

ENSP00000442057, OTTHUMP00000247147, ENST00000536961, OTTHUMT00000415834
NM_001177612.1 → NP_001171083.1 cyclin-dependent kinase 2-interacting protein isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks a 3' coding exon, that causes a frameshift, compared to variant 1. The resulting isoform (3) has shorter and distinct N- and C-termini compared to isoform 1.

Source sequence(s)

AL137229, BC000600, DA167716, DA699021

Consensus CDS

CCDS53915.1

UniProtKB/TrEMBL

F5H7P3

UniProtKB/Swiss-Prot

Q9BW66

Related

ENSP00000442377, OTTHUMP00000247148, ENST00000541568, OTTHUMT00000415835
NM_032630.2 → NP_116019.1 cyclin-dependent kinase 2-interacting protein isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK056112, BC000600

Consensus CDS

CCDS9972.1

UniProtKB/Swiss-Prot

Q9BW66

Related

ENSP00000216756, OTTHUMP00000246827, ENST00000216756, OTTHUMT00000415055

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p5 Primary Assembly

Range

102814619..102829253, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

82991712..83006254, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL137229.4 (21660..36294)	None
genomic	CH471061.1	EAW81785.1
		EAW81786.1
mRNA	AF228148.1	AAF44747.1
mRNA	AF228149.1	AAF44748.1
mRNA	AK056112.1	BAB71095.1
mRNA	BC000600.2	AAH00600.1
mRNA	BU174070.1	None
mRNA	BX248279.1	CAD62607.1
mRNA	CR457178.1	CAG33459.1
mRNA	DA167716.1	None
mRNA	DA699021.1	None