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    PDGFB platelet-derived growth factor beta polypeptide [ Homo sapiens ]

    Gene ID: 5155, updated on 19-May-2012
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    Summary

    Official Symbol
    PDGFBprovided by HGNC
    Official Full Name
    platelet-derived growth factor beta polypeptideprovided by HGNC
    Primary source
    HGNC:8800
    See related
    Ensembl:ENSG00000100311; HPRD:01815; MIM:190040; Vega:OTTHUMG00000151029
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIS; SSV; PDGF2; c-sis; FLJ12858
    Summary
    The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
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    Genomic context

    Location :
    22q13.1
    Sequence :
    Chromosome: 22; NC_000022.10 (39619685..39640957, complement)
    See PDGFB in Epigenomics, MapViewer

    Chromosome 22 - NC_000022.10Genomic Context describing neighboring genes Neighboring gene chromobox homolog 7 Neighboring gene FUN14 domain containing 2 pseudogene 4 Neighboring gene small nucleolar RNA, C/D box 83B Neighboring gene small nucleolar RNA, C/D box 83A Neighboring gene ribosomal protein L3

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The increased PDGF-A, PDGF-B and FGF-2 expression in recurrence of salivary gland pleomorphic adenoma. Soares AB, et al. J Clin Pathol, 2012 Mar. PMID 22174424.
    2. Myofibroblast-derived PDGF-BB promotes Hedgehog survival signaling in cholangiocarcinoma cells. Fingas CD, et al. Hepatology, 2011 Dec. PMID 22038837.
    3. Increase in serum platelet-derived growth factor (PDGF)-BB reflects lymph node involvement in esophageal cancer patients independently from platelet count. Krzystek-Korpacka M, et al. Exp Oncol, 2011 Sep. PMID 21956466.
    4. Coordinated increase in serum platelet-derived growth factor-BB and transforming growth factor-β1 in patients with chronic pancreatitis. Adrych K, et al. Pancreatology, 2011. PMID 21921666.
    5. Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling. Mermis J, et al. Respir Res, 2011 Aug 5. PMID 21819559.

    See all (200) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Report increased PDGF-A, PDGF-B and FGF-2 expression in recurrence of salivary gland pleomorphic adenoma.
      Title: The increased PDGF-A, PDGF-B and FGF-2 expression in recurrence of salivary gland pleomorphic adenoma.
    2. sPDGF-BB was significantly higher in esophageal cancer patients than controls and corresponded with the disease advancement.
      Title: Increase in serum platelet-derived growth factor (PDGF)-BB reflects lymph node involvement in esophageal cancer patients independently from platelet count.
    3. PDGF-BB is not superior to laminin as a potential marker of advanced chronic pancreatitis.
      Title: Coordinated increase in serum platelet-derived growth factor-BB and transforming growth factor-β1 in patients with chronic pancreatitis.
    4. myofibroblast-derived PDGF-BB protects cholangiocarcinomacells from TRAIL cytotoxicity by a Hh-signaling-dependent process
      Title: Myofibroblast-derived PDGF-BB promotes Hedgehog survival signaling in cholangiocarcinoma cells.
    5. Studies suggest that various isoforms of PDGF bind with differential affinities to two related tyrosine kinase receptors, denoted the PDGF alpha- and beta-receptors.
      Title: PDGF: the nuts and bolts of signalling toolbox.
    6. PDGF both contributes to the osteogenic lineage and helps to stabilize newly forming vessels that act to drive the multistep, multicomponent cascade of new bone formation.
      Title: PDGF in bone formation and regeneration: new insights into a novel mechanism involving MSCs.
    7. PDGFBB and HGF are related to severity of acute pancreatitis, and together with Ang-2 are related to clinical evolution.
      Title: Soluble angiogenic factors in patients with acute pancreatitis.
    8. Suggest the possible involvement of Hif-1alpha/PDGF-BB pathway in the development of HIV-1 associated pulmonary arterial hypertension.
      Title: Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling.
    9. During progression of hPDGFb-induced murine gliomas, tumor suppressor loss can expand the recruited cell population not derived from the cell-of-origin within glioma microenvironment.
      Title: Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression.
    10. High PDGFB is associated with colorectal cancer.
      Title: The clinical implications of platelet derived growth factor B, vascular endothelial growth factor and basic fibroblast growth factor in colorectal cancer.
    Submit: New GeneRIF Correction See all (122)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Dermatofibrosarcoma protuberans

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_148937.1     BIND  PubMed GFB-204 interacts with PDGF. 
    P01127 P01023 A2M    HPRD  PubMed  
    P01127 P52961 ART1    HPRD  PubMed  
    P01127 P02452 COL1A1    HPRD  PubMed  
    P01127 P01112 HRAS    HPRD  PubMed  
    P01127 P98160 HSPG2    HPRD  PubMed  
    P01127 Q07954 LRP1    HPRD  PubMed  
    P01127 Q13442 PDAP1    HPRD  PubMed  
    P01127 P01127 PDGFB    HPRD  PubMed  
    P01127 P16234 PDGFRA    HPRD  PubMed  
    P01127 P09619 PDGFRB    HPRD  PubMed  
    P01127 P07996 THBS1    HPRD  PubMed  
    BioGRID:111181 BioGRID:109571 HSPG2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111181 BioGRID:110215 LRP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111181 BioGRID:116461 PDAP1    BioGRID  PubMed Co-purification 
    BioGRID:111181 BioGRID:111181 PDGFB    BioGRID  PubMed Co-crystal Structure 
    BioGRID:111181 BioGRID:111182 PDGFRA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111181 BioGRID:112560 SPARC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111181 BioGRID:112915 THBS1    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Downstream signal transduction, organism-specific biosystem (from REACTOME)
      Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Gap junction, organism-specific biosystem (from KEGG)
      Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Gap junction, conserved biosystem (from KEGG)
      Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Glioma, organism-specific biosystem (from KEGG)
      Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glioma, conserved biosystem (from KEGG)
      Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Melanoma, organism-specific biosystem (from KEGG)
      Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Melanoma, conserved biosystem (from KEGG)
      Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Osteoblast Signaling, organism-specific biosystem (from WikiPathways)
      Osteoblast Signaling, organism-specific biosystem
      Osteoblast Signaling
    • Osteoclast Signaling, organism-specific biosystem (from WikiPathways)
      Osteoclast Signaling, organism-specific biosystem
      Osteoclast Signaling
    • PDGFR-beta signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      PDGFR-beta signaling pathway, organism-specific biosystem
      PDGFR-beta signaling pathway
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Platelet degranulation, organism-specific biosystem (from REACTOME)
      Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystem
      Regulation of Actin Cytoskeleton
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Renal cell carcinoma, organism-specific biosystem (from KEGG)
      Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Renal cell carcinoma, conserved biosystem (from KEGG)
      Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
      Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cell surface binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    collagen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    eukaryotic cell surface binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    platelet-derived growth factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    platelet-derived growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to platelet-derived growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    platelet-derived growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    platelet-derived growth factor receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    superoxide-generating NADPH oxidase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    activation of protein kinase B activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to mycophenolic acid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    embryonic placenta development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    metanephric glomerular mesangial cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    monocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of phosphatidylinositol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of platelet activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    paracrine signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    platelet activation TAS
    Traceable Author Statement
    more info
    		  
    platelet degranulation TAS
    Traceable Author Statement
    more info
    		  
    platelet-derived growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of blood vessel endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of calcium ion import IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cyclin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of glomerular filtration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of glomerular mesangial cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of metanephric mesenchymal cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of mitosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of phosphatidylinositol 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of phosphatidylinositol 3-kinase cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of reactive oxygen species metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of smooth muscle cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to drug IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to wounding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to wounding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    platelet-derived growth factor subunit B
    Names
    platelet-derived growth factor subunit B
    PDGF-2
    becaplermin
    PDGF, B chain
    PDGF subunit B
    proto-oncogene c-Sis
    platelet-derived growth factor 2
    platelet-derived growth factor B chain
    platelet-derived growth factor, B chain
    Platelet-derived growth factor, beta polypeptide (oncogene SIS)
    platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012111.1 RefSeqGene

      Range
      5001..26271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002608.2 → NP_002599.1  platelet-derived growth factor subunit B isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1) with a signal peptide.
      Source sequence(s)
      BC029822, BC077725, BM983641, M12783, X02811
      Consensus CDS
      CCDS13987.1
      UniProtKB/Swiss-Prot
      P01127
      Related
      ENSP00000330382, OTTHUMP00000198980, ENST00000331163, OTTHUMT00000321043
      Conserved Domains (2) summary
      cd00135
      Location:95 – 182
      Blast Score: 230
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
      pfam04692
      Location:21 – 96
      Blast Score: 241
      PDGF_N; Platelet-derived growth factor, N terminal region

    2. NM_033016.2 → NP_148937.1  platelet-derived growth factor subunit B isoform 2 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to transcript variant 1. This results in the use of a different start codon, and a shorter isoform (2) with a distinct N-terminus lacking a signal peptide, compared to isoform 1.
      Source sequence(s)
      BC029822, BM983641, X83705
      Consensus CDS
      CCDS33650.1
      UniProtKB/TrEMBL
      G3XAG8
      UniProtKB/Swiss-Prot
      P01127
      UniProtKB/TrEMBL
      Q15354
      Related
      ENSP00000370963, OTTHUMP00000198981, ENST00000381551, OTTHUMT00000321044
      Conserved Domains (2) summary
      cd00135
      Location:80 – 167
      Blast Score: 237
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
      pfam04692
      Location:7 – 81
      Blast Score: 233
      PDGF_N; Platelet-derived growth factor, N terminal region

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000022.10 Reference GRCh37.p5 Primary Assembly

      Range
      39619685..39640957, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000154.1 Alternate HuRef

      Range
      22586719..22607974, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic A37537.1 CAA02289.1
    genomic A37562.1 CAA02294.1
    genomic CH471095.1 EAW60305.1
      EAW60306.1
      EAW60307.1
      EAW60308.1
    genomic CQ858326.1 CAH23424.1
    genomic CS172383.1 CAJ32895.1
    genomic CS172827.1 CAJ32907.1
    genomic CS367418.1 CAL32766.1
    genomic HC040703.1 CBH30542.1
    genomic K01401.1 AAA60552.1
    genomic K01913.1 AAA98793.1
    genomic K01914.1 AAA98793.1
    genomic K01915.1 AAA98793.1
    genomic K01916.1 AAA98793.1
    genomic K01917.1 AAA98793.1
    genomic M19719.1 AAA60349.1
    genomic X00560.1 CAA25227.1
    genomic X00561.1 CAA25228.1
      CAA25229.1
    genomic X00562.1 CAA25230.1
    genomic X98706.1 CAA67262.1
    genomic Z81010.2 CAB02635.1
    mRNA AK022920.1 None
    mRNA BC029822.1 AAH29822.1
    mRNA BC077725.1 AAH77725.1
    mRNA BM983641.1 None
    mRNA CR456538.1 CAG30424.1
    mRNA CR541807.1 CAG46606.1
    mRNA M12783.1 AAA60553.1
    mRNA M32009.1 None
    mRNA X02744.1 CAA26524.1
    mRNA X02811.1 CAA26579.1
    mRNA X03702.1 CAA27333.1
    mRNA X83705.1 CAA58679.1
    other-genetic CU013138.1 CAK54569.1
    other-genetic CU013426.1 CAK54868.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01127.1 GenPept UniProtKB/Swiss-Prot:P01127
    P78450 GenPept UniProtKB/TrEMBL:P78450
    Q15354 GenPept UniProtKB/TrEMBL:Q15354
    Q9UE56 GenPept UniProtKB/TrEMBL:Q9UE56
    Q9UE57 GenPept UniProtKB/TrEMBL:Q9UE57
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