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SIRT6 sirtuin 6 [ Homo sapiens (human) ]

Gene ID: 51548, updated on 12-May-2016
Official Symbol
SIRT6provided by HGNC
Official Full Name
sirtuin 6provided by HGNC
Primary source
HGNC:HGNC:14934
See related
Ensembl:ENSG00000077463 HPRD:12093; MIM:606211; Vega:OTTHUMG00000181847
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIR2L6
Summary
This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Orthologs
Location:
19p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (4174109..4182599, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4174106..4182596, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase 2 Neighboring gene cAMP responsive element binding protein 3-like 3 Neighboring gene ankyrin repeat domain 24 Neighboring gene Epstein-Barr virus induced 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD(P)+-protein-arginine ADP-ribosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
NAD+ ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
NAD+ binding ISS
Inferred from Sequence or Structural Similarity
more info
 
NAD-dependent histone deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
NAD-dependent histone deacetylase activity (H3-K9 specific) IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent protein deacetylase activity TAS
Traceable Author Statement
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
base-excision repair IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
histone H3-K9 deacetylation IEA
Inferred from Electronic Annotation
more info
 
histone H3-K9 modification IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glycolytic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
post-embryonic cardiac muscle cell growth involved in heart morphogenesis IEA
Inferred from Electronic Annotation
more info
 
protein ADP-ribosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein ADP-ribosylation TAS
Traceable Author Statement
more info
PubMed 
protein destabilization IEA
Inferred from Electronic Annotation
more info
 
regulation of double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear telomeric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
NAD-dependent protein deacetylase sirtuin-6
Names
SIR2-like protein 6
regulatory protein SIR2 homolog 6
sir2-related protein type 6
sirtuin type 6
NP_001180214.1
NP_057623.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047153.1 RefSeqGene

    Range
    4996..13491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001193285.2NP_001180214.1  NAD-dependent protein deacetylase sirtuin-6 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC006930, AC016586, BC028220, CN364177
    Consensus CDS
    CCDS54199.1
    UniProtKB/Swiss-Prot
    Q8N6T7
    Related
    ENSP00000305310, OTTHUMP00000267649, ENST00000305232, OTTHUMT00000457930
    Conserved Domains (1) summary
    cl00195
    Location:45230
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  2. NM_001321058.1NP_001307987.1  NAD-dependent protein deacetylase sirtuin-6 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC016586, AK293348, BC028220, CN364177
    Conserved Domains (1) summary
    cl00195
    Location:1185
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  3. NM_001321059.1NP_001307988.1  NAD-dependent protein deacetylase sirtuin-6 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC006930, AK225567, BC028220, BQ060703, CN364177
    Conserved Domains (1) summary
    cl00195
    Location:45196
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  4. NM_001321060.1NP_001307989.1  NAD-dependent protein deacetylase sirtuin-6 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC006930, AK225567, BC028220, CN364175, CN364177
    Conserved Domains (1) summary
    cl00195
    Location:45205
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  5. NM_001321061.1NP_001307990.1  NAD-dependent protein deacetylase sirtuin-6 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC016586, BC004218, BC028220, CN364177
    Conserved Domains (1) summary
    cl00195
    Location:1158
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  6. NM_001321062.1NP_001307991.1  NAD-dependent protein deacetylase sirtuin-6 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC006930, AK225567, BC028220, BP418952, CN364177
    Conserved Domains (1) summary
    cl00195
    Location:1122
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  7. NM_001321063.1NP_001307992.1  NAD-dependent protein deacetylase sirtuin-6 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC006930, AK225567, BC028220, BE281103, CN364177
    Conserved Domains (1) summary
    cl00195
    Location:45144
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  8. NM_001321064.1NP_001307993.1  NAD-dependent protein deacetylase sirtuin-6 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC006930, AK074810, AL559383, BC028220
    Conserved Domains (1) summary
    cl00195
    Location:1133
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  9. NM_016539.3NP_057623.2  NAD-dependent protein deacetylase sirtuin-6 isoform 1

    See identical proteins and their annotated locations for NP_057623.2

    Status: REVIEWED

    Source sequence(s)
    AK074810, BC005026, CN364177
    Consensus CDS
    CCDS12122.1
    UniProtKB/Swiss-Prot
    Q8N6T7
    Related
    ENSP00000337332, OTTHUMP00000267650, ENST00000337491, OTTHUMT00000457931
    Conserved Domains (1) summary
    cd01410
    Location:45257
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    4174109..4182599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259577.3XP_005259634.1  

    Conserved Domains (1) summary
    cl00195
    Location:45205
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  2. XM_005259574.1XP_005259631.1  

    Related
    ENSP00000470215, OTTHUMP00000267696, ENST00000597896, OTTHUMT00000457997
    Conserved Domains (1) summary
    cl00195
    Location:45196
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  3. XM_005259575.1XP_005259632.1  

    UniProtKB/TrEMBL
    B4DDV3
    Conserved Domains (1) summary
    cl00195
    Location:1185
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    4173652..4182142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)