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    ANAPC11 anaphase promoting complex subunit 11 [ Homo sapiens ]

    Gene ID: 51529, updated on 19-May-2012
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    Summary

    Official Symbol
    ANAPC11provided by HGNC
    Official Full Name
    anaphase promoting complex subunit 11provided by HGNC
    Primary source
    HGNC:14452
    Locus tag
    HSPC214
    See related
    Ensembl:ENSG00000141552; HPRD:12452; MIM:614534
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APC11; Apc11p; HSPC214; MGC882
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    Genomic context

    Location :
    17q25.3
    Sequence :
    Chromosome: 17; NC_000017.10 (79849599..79858363)
    See ANAPC11 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene Rho GDP dissociation inhibitor (GDI) alpha Neighboring gene Aly/REF export factor Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene neuropeptide B Neighboring gene sirtuin 7

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Mansfeld J, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926987.
    2. Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex. Mo M, et al. J Gen Virol, 2010 Dec. PMID 20826619.
    3. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068.
    4. UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex. Wu T, et al. Proc Natl Acad Sci U S A, 2010 Jan 26. PMID 20080579.
    5. The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression. Wäsch R, et al. Oncogene, 2010 Jan 7. PMID 19826416.

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The authors showed, in vitro, a direct interaction between Orf virus anaphase promoting complex regulator and APC2 and its interference with interactions between APC11 and APC2.
      Title: Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex.
    2. Studies indicate that APC/C(Cdh1) is required to maintain genomic stability.
      Title: The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.
    3. APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.
      Title: APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.
    4. Inhibition of APC11 function by H(2)O(2) contributes to the delay in cell cycle progression through mitosis that is characteristic of cells subjected to oxidative stress
      Title: The RING-H2-finger protein APC11 as a target of hydrogen peroxide.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9NYG5 Q9UM13 ANAPC10    HPRD  PubMed  
    Q9NYG5 Q9NYG5 ANAPC11    HPRD  PubMed  
    Q9NYG5 Q9UJX6 ANAPC2    HPRD  PubMed  
    Q9NYG5 Q13042 CDC16    HPRD  PubMed  
    Q9NYG5 O00762 UBE2C    HPRD  PubMed  
    BioGRID:119591 BioGRID:122229 ANAPC1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119591 BioGRID:115665 ANAPC10    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119591 BioGRID:118937 ANAPC2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:119591 BioGRID:118982 ANAPC4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119591 BioGRID:115585 APC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119591 BioGRID:107332 CCNB1    BioGRID  PubMed Biochemical Activity 
    BioGRID:119591 BioGRID:107427 CDC20    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119591 BioGRID:107431 CDC27    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:119591 BioGRID:107434 CDH1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119591 BioGRID:113743 CUL5    BioGRID  PubMed Two-hybrid 
    BioGRID:119591 BioGRID:213776 Cdc16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119591 BioGRID:206665 Cdc23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119591 BioGRID:114663 PTTG1    BioGRID  PubMed Biochemical Activity 
    BioGRID:119591 BioGRID:113164 UBC    BioGRID  PubMed Biochemical Activity 
    BioGRID:119591 BioGRID:129602 UBE2L1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119591 BioGRID:127156 UBE2U    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • APC/C complex, organism-specific biosystem (from KEGG)
      APC/C complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • APC/C complex, conserved biosystem (from KEGG)
      APC/C complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
    • APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
      APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
    • APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystemThe degradation of cyclin B1, which appears to occur at the mitotic spindle, is delayed until the metaphase /anaphase transition by the spindle assembly checkpoint and is required in order for sister...
    • APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystemThe separation of sister chromatids in anaphase requires the destruction of the anaphase inhibitor, securin. Securin associates with and inactivates the protease, separase. Separase cleaves the cohe...
    • APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemFollowing phosphorylation of the APC/C core subunits by mitotic kinases, the activating protein, Cdc20 is recruited to the APC and promotes the multiubiquitination and subsequent degradation of the ...
    • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem (from REACTOME)
      APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystemFrom late mitosis through G1 phase APC/C:Cdh1 insures the continued degradation of the mitotic proteins and during mitotic exit and G1 its substrates include Cdc20, Plk1, Aurora A, Cdc6 and Gemin...
    • Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
      Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemAPC/C:Cdc20 is first activated at the prometaphase/metaphase transition through phosphorylation of core subunits of the APC/C by mitotic kinases as well as recruitment of the APC/C activator protein ...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Autodegradation of Cdh1 by Cdh1:APC/C, organism-specific biosystem (from REACTOME)
      Autodegradation of Cdh1 by Cdh1:APC/C, organism-specific biosystemCdh1 is degraded by the APC/C during in G1 and G0. This auto-regulation may contribute to reducing the levels of Cdh1 levels during G1 and G0 (Listovsky et al., 2004).
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, organism-specific biosystem (from REACTOME)
      Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, organism-specific biosystemThe activity of the APC/C must be appropriately regulated during the cell cycle to ensure the timely degradation of its substrates. Of particular importance is the conversion from APC/C:Cdc20 to APC...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inactivation of APC/C via direct inhibition of the APC/C complex, organism-specific biosystem (from REACTOME)
      Inactivation of APC/C via direct inhibition of the APC/C complex, organism-specific biosystemIn the direct inhibition model, the cytosolic Mitotic Checkpoint Complex, consisting of hBUBR1, hBUB3, Cdc20 and Mad2, directly inhibits APC/C by binding to it.
    • Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, organism-specific biosystem (from REACTOME)
      Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, organism-specific biosystemThe target of the mitotic checkpoint is the Anaphase Promoting Complex/Cyclosome (APC/C) an E3 ubiquitin ligase that targets proteins whose destruction is essential for mitotic exit. Currently, there...
    • Mitotic Spindle Checkpoint, organism-specific biosystem (from REACTOME)
      Mitotic Spindle Checkpoint, organism-specific biosystemThe mitotic checkpoint or spindle assembly checkpoint is an evolutionarily conserved mechanism that ensures that cells with misaligned chromosomes do not exit mitosis and divide to form aneuploid cel...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Phosphorylation of the APC/C, organism-specific biosystem (from REACTOME)
      Phosphorylation of the APC/C, organism-specific biosystemPhosphorylation of APC subunits is required for Cdc20 mediated activation by of the APC/C at the metaphase anaphase transition (Kramer et al., 2000). While the kinases responsible for phosphorylation...
    • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
      Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemThe APC/C is activated by either Cdc20 or Cdh1. While both activators associate with the APC/C, they do so at different points in the cell cycle and their binding is regulated differently (see Zacha...
    • Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
      Regulation of mitotic cell cycle, organism-specific biosystem
      Regulation of mitotic cell cycle
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		  
    cell cycle checkpoint TAS
    Traceable Author Statement
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    mitotic cell cycle spindle assembly checkpoint TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    anaphase-promoting complex subunit 11
    Names
    anaphase-promoting complex subunit 11
    cyclosome subunit 11
    APC11 anaphase promoting complex subunit 11 homolog
    hepatocellular carcinoma-associated RING finger protein
    anaphase promoting complex subunit 11 (yeast APC11 homolog)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002244.1 → NP_001002244.1  anaphase-promoting complex subunit 11 isoform 1

      Status: VALIDATED

      Source sequence(s)
      BC000607, BU554167, BU556841, CB106395
      Consensus CDS
      CCDS32769.1
      UniProtKB/Swiss-Prot
      Q9NYG5
      Related
      ENSP00000349957, ENST00000357385
      Conserved Domains (1) summary
      cl15348
      Location:1 – 51
      Blast Score: 189
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_001002245.1 → NP_001002245.1  anaphase-promoting complex subunit 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AF151048, BC000607, BG707824, BU554167, BU556841, CB106395
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      Q9NYG5
      Related
      ENSP00000461648, ENST00000571024
      Conserved Domains (1) summary
      cl15348
      Location:1 – 84
      Blast Score: 338
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    3. NM_001002246.1 → NP_001002246.1  anaphase-promoting complex subunit 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AF151048, BC000607, BU554167, BU556841, CB106395
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      Q9NYG5
      Related
      ENSP00000460064, ENST00000574924
      Conserved Domains (1) summary
      cl15348
      Location:1 – 84
      Blast Score: 338
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    4. NM_001002247.1 → NP_001002247.1  anaphase-promoting complex subunit 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC000607, BU554167, BU556841, CB106395
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      Q9NYG5
      Related
      ENSP00000458265, ENST00000572851
      Conserved Domains (1) summary
      cl15348
      Location:1 – 84
      Blast Score: 338
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    5. NM_001002248.1 → NP_001002248.1  anaphase-promoting complex subunit 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AF151048, BC000607, BU554167, BU556841, CB106395
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      Q9NYG5
      Related
      ENSP00000459200, ENST00000571874
      Conserved Domains (1) summary
      cl15348
      Location:1 – 84
      Blast Score: 338
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    6. NM_001002249.1 → NP_001002249.1  anaphase-promoting complex subunit 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AF151048, BC000607, BF435042, BM845909, BU554167, BU556841
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      Q9NYG5
      Related
      ENSP00000376181, ENST00000392376
      Conserved Domains (1) summary
      cl15348
      Location:1 – 84
      Blast Score: 338
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    7. NM_016476.10 → NP_057560.8  anaphase-promoting complex subunit 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AF151048, BC000607, BF512771, BU554167, BU556841
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      Q9NYG5
      Related
      ENSP00000339695, ENST00000344877
      Conserved Domains (1) summary
      cl15348
      Location:1 – 84
      Blast Score: 338
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      79849599..79858363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      75220929..75260043
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC145207.2 (86492..95256) None
    genomic CH471099.1 EAW89700.1
      EAW89701.1
      EAW89702.1
      EAW89703.1
    mRNA AF151048.1 AAF36134.1
    mRNA AF247565.1 AAF65816.1
    mRNA AF247789.1 AAL95694.1
    mRNA AK091360.1 None
    mRNA AK307214.1 None
    mRNA AK308091.1 None
    mRNA BC000607.1 AAH00607.2
    mRNA BC066308.1 AAH66308.1
    mRNA BC095454.1 AAH95454.1
    mRNA BC104641.1 AAI04642.1
    mRNA BC171892.1 AAI71892.1
    mRNA BC171898.1 AAI71898.1
    mRNA BC171899.1 AAI71899.1
    mRNA BC171900.1 AAI71900.1
    mRNA BF435042.1 None
    mRNA BF512771.1 None
    mRNA BG707824.1 None
    mRNA BM845909.1 None
    mRNA BU554167.1 None
    mRNA BU556841.1 None
    mRNA CB106395.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NYG5.1 GenPept UniProtKB/Swiss-Prot:Q9NYG5
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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