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    PDE9A phosphodiesterase 9A [ Homo sapiens (human) ]

    Gene ID: 5152, updated on 5-May-2013
    Official Symbol
    PDE9Aprovided by HGNC
    Official Full Name
    phosphodiesterase 9Aprovided by HGNC
    Primary source
    HGNC:8795
    See related
    Ensembl:ENSG00000160191; HPRD:09115; MIM:602973; Vega:OTTHUMG00000086825
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSPDE9A2
    Summary
    The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Location :
    21q22.3
    Sequence :
    Chromosome: 21; NC_000021.8 (44073862..44195619)
    See PDE9A in Epigenomics, MapViewer

    Chromosome 21 - NC_000021.8Genomic Context describing neighboring genes Neighboring gene radial spoke head 1 homolog (Chlamydomonas) Neighboring gene solute carrier family 37 (glycerol-3-phosphate transporter), member 1 Neighboring gene WD repeat domain 4 Neighboring gene NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Evaluation of PDE5 and PDE9 expression in benign and malignant breast tumors. Karami-Tehrani F, et al. Arch Med Res, 2012 Aug. PMID 22960860.
    2. Genome-wide association study of lung function decline in adults with and without asthma. Imboden M, et al. J Allergy Clin Immunol, 2012 May. PMID 22424883.
    3. Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo. Kleiman RJ, et al. J Pharmacol Exp Ther, 2012 May. PMID 22328573.
    4. Phosphodiesterase type 9 (PDE9) in the human lower urinary tract: an immunohistochemical study. Nagasaki S, et al. BJU Int, 2012 Mar. PMID 21736695.
    5. Inhibition of phosphodiesterase 9A reduces cytokine-stimulated in vitro adhesion of neutrophils from sickle cell anemia individuals. Miguel LI, et al. Inflamm Res, 2011 Jul. PMID 21336703.

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. it is concluded that assessment of PDE5 and PDE9 expression may be useful in the differential diagnosis of benign and malignant breast disease and successful treatment of breast cancer
      Title: Evaluation of PDE5 and PDE9 expression in benign and malignant breast tumors.
    2. In vivo effects of PDE9A inhibition included reversal of the respective disruptions of working memory.
      Title: Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.
    3. PDE9 is widely distributed in the urothelial epithelium of the human lower urinary tract and its potential roles may be different from those of PDE5.
      Title: Phosphodiesterase type 9 (PDE9) in the human lower urinary tract: an immunohistochemical study.
    4. Data show that PDE9A inhibitor, BAY-73-6691, significantly reduced basal and sickle cell (SCA) neutrophil adhesion; this was accompanied by decreased SCA neutrophil surface expressions of the L-selectin and CD11b adhesion molecules.
      Title: Inhibition of phosphodiesterase 9A reduces cytokine-stimulated in vitro adhesion of neutrophils from sickle cell anemia individuals.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Poor replication of candidate genes for major depressive disorder using genome-wide association data.
    7. PDE9A, is unlikely to play an important role in antidepressant outcome in this sample
      Title: Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sample.
    8. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sample.
    9. X ray crystallography with IBMX inhibitor binding
      Title: Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding.
    10. Identification and distribution of different variants produced by differential splicing of phosphodiesterase 9A mRNA.
      Title: Identification and distribution of different mRNA variants produced by differential splicing in the human phosphodiesterase 9A gene.
    Submit: New GeneRIF Correction See all (11)

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    O76083 O76083 PDE9A    HPRD  PubMed  
    O76083 Phytanoyl-CoA hydroxylase interacting protein-like PHYHIPL    HPRD  PubMed  
    O76083 Q13049 TRIM32    HPRD  PubMed  
    BioGRID:111178 BioGRID:111178 PDE9A    BioGRID  PubMed Two-hybrid 
    BioGRID:111178 BioGRID:124092 PHYHIPL    BioGRID  PubMed Two-hybrid 
    BioGRID:111178 BioGRID:116608 TRIM32    BioGRID  PubMed Two-hybrid 

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ90181

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    3',5'-cyclic-GMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    3',5'-cyclic-nucleotide phosphodiesterase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
    Names
    high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
    phosphodiesterase PDE9A21
    CGMP-specific 3',5'-cyclic phosphodiesterase type 9
    NP_001001567.1
    NP_001001568.1
    NP_001001569.1
    NP_001001570.1
    NP_001001571.1
    NP_001001572.1
    NP_001001573.1
    NP_001001574.1
    NP_001001575.1
    NP_001001576.1
    NP_001001577.1
    NP_001001578.1
    NP_001001579.1
    NP_001001580.1
    NP_001001581.1
    NP_001001582.1
    NP_001001583.1
    NP_001001584.1
    NP_001001585.1
    NP_002597.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001567.1 → NP_001001567.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but lacks an internal segment compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AF067224, AI492065, BC009047
      Consensus CDS
      CCDS33568.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000335242, OTTHUMP00000109392, ENST00000335512, OTTHUMT00000195458
      Conserved Domains (1) summary
      cd00077
      Location:252 – 425
      Blast Score: 143
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    2. NM_001001568.1 → NP_001001568.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks three alternate exons compared to variant 1. The resulting predicted isoform (c) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AF067225, AI492065, AY196305, BC009047
      Consensus CDS
      CCDS42946.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000381280, OTTHUMP00000109390, ENST00000398224, OTTHUMT00000195455
      Conserved Domains (1) summary
      cl00076
      Location:184 – 406
      Blast Score: 533
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    3. NM_001001569.1 → NP_001001569.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks four alternate exons compared to variant 1. The resulting predicted isoform (d) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AF067226, AI492065, AY196305, BC009047
      Consensus CDS
      CCDS33571.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000344730, OTTHUMP00000109389, ENST00000349112, OTTHUMT00000195454
      Conserved Domains (1) summary
      cd00077
      Location:184 – 357
      Blast Score: 139
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    4. NM_001001570.1 → NP_001001570.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate exon and lacks two others compared to variant 1. The resulting isoform (e) has the same N- and C-termini but differs in an internal segment compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AI492065, AY196299, BC009047
      Consensus CDS
      CCDS33567.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000369685, OTTHUMP00000109388, ENST00000380328, OTTHUMT00000195451
      Conserved Domains (1) summary
      cd00077
      Location:259 – 432
      Blast Score: 142
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    5. NM_001001571.1 → NP_001001571.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two alternate exons compared to variant 1. The resulting predicted isoform (f) is shorter, has a distinct N-terminus, and lacks an internal segment compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AI492065, AY196300, BC009047
      Consensus CDS
      CCDS42943.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000381289, OTTHUMP00000109393, ENST00000398234, OTTHUMT00000195459
      Conserved Domains (1) summary
      cd00077
      Location:211 – 384
      Blast Score: 140
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    6. NM_001001572.1 → NP_001001572.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks four alternate exons compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.
      Source sequence(s)
      AF048837, AF067223, AI492065, AY196301, BC009047
      UniProtKB/Swiss-Prot
      O76083
      Conserved Domains (1) summary
      cd00077
      Location:105 – 278
      Blast Score: 142
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    7. NM_001001573.1 → NP_001001573.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks three alternate exons compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.
      Source sequence(s)
      AF048837, AF067223, AI492065, AY196302, BC009047
      UniProtKB/Swiss-Prot
      O76083
      Conserved Domains (1) summary
      cd00077
      Location:105 – 278
      Blast Score: 142
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    8. NM_001001574.1 → NP_001001574.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (h) has the same N- and C-termini but lacks two internal segments compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AI492065, AY196303, BC009047
      Consensus CDS
      CCDS42941.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000381291, OTTHUMP00000109394, ENST00000398236, OTTHUMT00000195460
      Conserved Domains (1) summary
      cd00077
      Location:226 – 399
      Blast Score: 142
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    9. NM_001001575.1 → NP_001001575.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks five alternate exons compared to variant 1. The resulting predicted isoform (i) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AI492065, AY196304, BC009047
      Consensus CDS
      CCDS42947.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000381283, OTTHUMP00000109400, ENST00000398227, OTTHUMT00000195470
      Conserved Domains (1) summary
      cd00077
      Location:152 – 325
      Blast Score: 137
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    10. NM_001001576.1 → NP_001001576.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks five alternate exons compared to variant 1. The resulting predicted isoform (j) is shorter and has a distinct N-terminus compared to isoform a. Variants 11 and 15 both encode isoform j.
      Source sequence(s)
      AF048837, AF067223, AI492065, AY196305, BC009047
      UniProtKB/Swiss-Prot
      O76083
      Conserved Domains (1) summary
      cd00077
      Location:95 – 268
      Blast Score: 143
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    11. NM_001001577.1 → NP_001001577.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) lacks four alternate exons compared to variant 1. The resulting predicted isoform (k) is shorter, has a distinct N-terminus, and lacks an internal segment compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AI492065, AY196306, BC009047
      Consensus CDS
      CCDS42944.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000381285, OTTHUMP00000109399, ENST00000398229, OTTHUMT00000195469
      Conserved Domains (1) summary
      cd00077
      Location:178 – 351
      Blast Score: 139
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    12. NM_001001578.1 → NP_001001578.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform l

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) lacks three alternate exons compared to variant 1. The resulting isoform (l) has the same N- and C-termini but lacks two internal segments compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AI492065, AY196307, BC009047
      Consensus CDS
      CCDS33570.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000335365, OTTHUMP00000109396, ENST00000335440, OTTHUMT00000195463
      Conserved Domains (1) summary
      cd00077
      Location:210 – 383
      Blast Score: 136
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    13. NM_001001579.1 → NP_001001579.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) lacks three alternate exons compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.
      Source sequence(s)
      AF048837, AF067223, AI492065, AY196308, BC009047
      UniProtKB/Swiss-Prot
      O76083
      Conserved Domains (1) summary
      cd00077
      Location:105 – 278
      Blast Score: 142
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    14. NM_001001580.1 → NP_001001580.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) lacks six alternate exons compared to variant 1. The resulting predicted isoform (j) is shorter and has a distinct N-terminus compared to isoform a. Variants 11 and 15 both encode isoform j.
      Source sequence(s)
      AF048837, AF067223, AI492065, AY196309, BC009047
      UniProtKB/Swiss-Prot
      O76083
      Conserved Domains (1) summary
      cd00077
      Location:95 – 268
      Blast Score: 143
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    15. NM_001001581.1 → NP_001001581.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform m

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) lacks two alternate exons compared to variant 1. The resulting predicted isoform (m) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AI492065, AY196310, BC009047
      Consensus CDS
      CCDS42945.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000381287, OTTHUMP00000109391, ENST00000398232, OTTHUMT00000195456
      Conserved Domains (1) summary
      cd00077
      Location:245 – 418
      Blast Score: 145
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    16. NM_001001582.1 → NP_001001582.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform n

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) lacks an alternate exon compared to variant 1. The resulting predicted isoform (n) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AI492065, AY196311, BC009047
      Consensus CDS
      CCDS42942.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000381281, OTTHUMP00000109397, ENST00000398225, OTTHUMT00000195464
      Conserved Domains (1) summary
      cd00077
      Location:271 – 444
      Blast Score: 146
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    17. NM_001001583.1 → NP_001001583.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform o

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (o) has the same N- and C-termini but lacks an internal segment compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AI492065, AY196312, BC009047
      Consensus CDS
      CCDS33569.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000328699, OTTHUMP00000109395, ENST00000328862, OTTHUMT00000195462
      Conserved Domains (1) summary
      cd00077
      Location:286 – 459
      Blast Score: 147
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    18. NM_001001584.2 → NP_001001584.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19) contains an alternate exon and lacks three others compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.
      Source sequence(s)
      AF048837, AF067223, AI492065, AP001627, AY196313, BC009047
      UniProtKB/Swiss-Prot
      O76083
      Conserved Domains (1) summary
      cd00077
      Location:105 – 278
      Blast Score: 142
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    19. NM_001001585.1 → NP_001001585.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20) lacks two alternate exons compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.
      Source sequence(s)
      AF048837, AF067223, AI492065, AY196314, BC009047
      UniProtKB/Swiss-Prot
      O76083
      Conserved Domains (1) summary
      cd00077
      Location:105 – 278
      Blast Score: 142
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    20. NM_002606.2 → NP_002597.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AF048837, AF067223, AI492065, BC009047
      Consensus CDS
      CCDS13690.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000291539, OTTHUMP00000109398, ENST00000291539, OTTHUMT00000195466
      Conserved Domains (1) summary
      cd00077
      Location:312 – 485
      Blast Score: 149
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000021.8 Reference GRCh37.p10 Primary Assembly

      Range
      44073862..44195619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000153.1 Alternate HuRef

      Range
      29521492..29610642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018932.1 Alternate CHM1_1.0

      Range
      34605609..34694876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic AB017602.1 BAA88847.1
    genomic ABBA01004532.1 None
    genomic ABBA01004533.1 None
    genomic ABBA01004534.1 None
    genomic ABBA01004535.1 None
    genomic AMYH01012270.1 (32107..121374) None
    genomic AP001626.1 (79657..97923) None
    genomic AP001627.1 None
    genomic AP001628.1 None
    genomic AP001747.1 BAA95552.1
    genomic CH471079.2 EAX09531.1
      EAX09532.1
      EAX09533.1
      EAX09534.1
      EAX09535.1
      EAX09536.1
      EAX09537.1
      EAX09538.1
      EAX09539.1
      EAX09540.1
      EAX09541.1
      EAX09542.1
      EAX09543.1
      EAX09544.1
      EAX09545.1
      EAX09546.1
      EAX09547.1
      EAX09548.1
      EAX09549.1
    mRNA AF048837.1 AAC39778.1
    mRNA AF067223.1 AAC26723.1
    mRNA AF067224.1 AAC26724.1
    mRNA AF067225.1 AAC26725.1
    mRNA AF067226.1 AAC26726.1
    mRNA AI492065.1 None
    mRNA AK001165.1 None
    mRNA AK001307.1 None
    mRNA AK074662.1 BAC11120.1
    mRNA AK127770.1 None
    mRNA AK294112.1 BAG57446.1
    mRNA AK308753.1 None
    mRNA AK314679.1 BAG37232.1
    mRNA AY196299.1 AAO34685.1
    mRNA AY196300.1 AAO34686.1
    mRNA AY196301.1 AAO34687.1
    mRNA AY196302.1 AAO34688.1
    mRNA AY196303.1 AAO34689.1
    mRNA AY196304.1 AAO34690.1
    mRNA AY196305.1 AAO34691.1
    mRNA AY196306.1 AAO34692.1
    mRNA AY196307.1 AAO34693.1
    mRNA AY196308.1 AAO34694.1
    mRNA AY196309.1 AAO34695.1
    mRNA AY196310.1 AAO34696.1
    mRNA AY196311.1 AAO34697.1
    mRNA AY196312.1 AAO34698.1
    mRNA AY196313.1 AAO34699.1
    mRNA AY196314.1 AAO34700.1
    mRNA AY242121.1 AAO88210.1
    mRNA AY701187.1 AAV84271.1
    mRNA BC009047.1 AAH09047.1
    mRNA BT007016.1 AAP35662.1
    other-genetic GQ129331.1 ACT64465.1
    other-genetic GQ129332.1 ACT64466.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76083.1 GenPept UniProtKB/Swiss-Prot:O76083

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioAssay, by Protein Target
        BioAssay, by Protein Target
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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