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    PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta [ Homo sapiens ]

    Gene ID: 5147, updated on 11-May-2012
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    Summary

    Official Symbol
    PDE6Dprovided by HGNC
    Official Full Name
    phosphodiesterase 6D, cGMP-specific, rod, deltaprovided by HGNC
    Primary source
    HGNC:8788
    See related
    Ensembl:ENSG00000156973; HPRD:04056; MIM:602676; Vega:OTTHUMG00000153785
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PDED
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    Genomic context

    Location :
    2q35-q36
    Sequence :
    Chromosome: 2; NC_000002.11 (232597147..232645974, complement)
    See PDE6D in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene chromosome 2 open reading frame 57 Neighboring gene microRNA 1244-1 Neighboring gene prothymosin, alpha Neighboring gene COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis) Neighboring gene ribosomal protein L28 pseudogene 2 Neighboring gene guanidinoacetate N-methyltransferase pseudogene 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins. Chandra A, et al. Nat Cell Biol, 2011 Dec 18. PMID 22179043.
    2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    3. Many sequence variants affecting diversity of adult human height. Gudbjartsson DF, et al. Nat Genet, 2008 May. PMID 18391951.
    4. Internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the delta subunit of cGMP phosphodiesterase 6. Wilson SJ, et al. J Biol Chem, 2006 Apr 28. PMID 16527812.
    5. Assay and functional properties of PrBP(PDEdelta), a prenyl-binding protein interacting with multiple partners. Zhang H, et al. Methods Enzymol, 2005. PMID 16473576.

    See all (18) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data show that PDEdelta activity augments K/Hras signalling by enriching Ras at the plasma membrane.
      Title: The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Many sequence variants affecting diversity of adult human height.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O43924 ADP ribosylation factor related protein 2 ARL15    HPRD  PubMed  
    O43924 P36404 ARL2    HPRD  PubMed  
    O43924 P36405 ARL3    HPRD  PubMed  
    O43924 P60953 CDC42    HPRD  PubMed  
    O43924 O15182 CETN3    HPRD  PubMed  
    O43924 Q8IW50 FAM219A    HPRD  PubMed  
    O43924 P63096 GNAI1    HPRD  PubMed  
    O43924 Q15835 GRK1    HPRD  PubMed  
    O43924 Q8WTQ7 GRK7    HPRD  PubMed  
    O43924 P01112 HRAS    HPRD  PubMed  
    O43924 P43119 PTGIR    HPRD  PubMed  
    O43924 P51153 RAB13    HPRD  PubMed  
    O43924 Q9NP72 RAB18    HPRD  PubMed  
    O43924 P61006 RAB8A    HPRD  PubMed  
    O43924 P54725 RAD23A    HPRD  PubMed  
    O43924 P62834 RAP1A    HPRD  PubMed  
    O43924 P61225 RAP2B    HPRD  PubMed  
    O43924 P20936 RASA1    HPRD  PubMed  
    O43924 Q15382 RHEB    HPRD  PubMed  
    O43924 P61586 RHOA    HPRD  PubMed  
    O43924 P62745 RHOB    HPRD  PubMed  
    O43924 Q92730 RND1    HPRD  PubMed  
    O43924 Q92834 RPGR    HPRD  PubMed  
    BioGRID:111173 BioGRID:120080 ARL15    BioGRID  PubMed Two-hybrid 
    BioGRID:111173 BioGRID:106895 ARL2    BioGRID  PubMed Co-crystal Structure; Two-hybrid 
    BioGRID:111173 BioGRID:106896 ARL3    BioGRID  PubMed Two-hybrid 
    BioGRID:111173 BioGRID:207906 Arl2    BioGRID  PubMed Two-hybrid 
    BioGRID:111173 BioGRID:207916 Arl3    BioGRID  PubMed Two-hybrid 
    BioGRID:111173 BioGRID:107433 CDC42    BioGRID  PubMed Two-hybrid 
    BioGRID:111173 BioGRID:107497 CETN3    BioGRID  PubMed Two-hybrid 
    BioGRID:111173 BioGRID:128461 FAM219A    BioGRID  PubMed Two-hybrid 
    BioGRID:111173 BioGRID:109501 HRAS    BioGRID  PubMed Two-hybrid 
    BioGRID:111173 BioGRID:111810 RAB13    BioGRID  PubMed Two-hybrid 
    BioGRID:111173 BioGRID:116591 RAB18    BioGRID  PubMed Two-hybrid 
    BioGRID:111173 BioGRID:111823 RAD23A    BioGRID  PubMed Two-hybrid 
    BioGRID:111173 BioGRID:111841 RAP1A    BioGRID  PubMed Two-hybrid 
    BioGRID:111173 BioGRID:111847 RAP2B    BioGRID  PubMed Two-hybrid 
    BioGRID:111173 BioGRID:111941 RHEB    BioGRID  PubMed Two-hybrid 
    BioGRID:111173 BioGRID:106880 RHOA    BioGRID  PubMed Two-hybrid 
    BioGRID:111173 BioGRID:106881 RHOB    BioGRID  PubMed Two-hybrid 
    BioGRID:111173 BioGRID:118113 RND1    BioGRID  PubMed Two-hybrid 
    BioGRID:111173 BioGRID:112030 RPGR    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111173 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    GTPase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    negative regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of GTP catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
    Names
    retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
    protein p17
    GMP-PDE delta
    NP_002592.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002601.2 → NP_002592.1  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

      Status: VALIDATED

      Source sequence(s)
      BC001054, BC007831
      Consensus CDS
      CCDS33398.1
      UniProtKB/Swiss-Prot
      O43924
      UniProtKB/TrEMBL
      Q6IB24
      Related
      ENSP00000287600, OTTHUMP00000204402, ENST00000287600, OTTHUMT00000332407
      Conserved Domains (1) summary
      pfam05351
      Location:7 – 150
      Blast Score: 520
      GMP_PDE_delta; GMP-PDE, delta subunit

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      232597147..232645974, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      224440043..224488796, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC073476.6 AAY24151.1
    genomic AF042835.1 AAC25953.1
    genomic AF045999.1 AAC39720.1
    genomic CH471063.1 EAW70977.1
      EAW70978.1
    mRNA AF022912.1 AAB87872.1
    mRNA AJ001626.1 CAA04880.1
    mRNA BC001054.2 None
    mRNA BC007831.2 AAH07831.1
    mRNA BC017467.1 None
    mRNA BT007278.1 AAP35942.1
    mRNA CR456980.1 CAG33261.1
    other-genetic DQ893223.2 ABM84149.1
    other-genetic DQ896553.2 ABM87552.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43924.1 GenPept UniProtKB/Swiss-Prot:O43924
    Q6IB24 GenPept UniProtKB/TrEMBL:Q6IB24
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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