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    UBE2J1 ubiquitin-conjugating enzyme E2, J1, U [ Homo sapiens ]

    Gene ID: 51465, updated on 19-May-2012
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    Summary

    Official Symbol
    UBE2J1provided by HGNC
    Official Full Name
    ubiquitin-conjugating enzyme E2, J1, Uprovided by HGNC
    Primary source
    HGNC:17598
    Locus tag
    CGI-76
    See related
    Ensembl:ENSG00000198833; HPRD:15599; Vega:OTTHUMG00000016337
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBC6; Ubc6p; CGI-76; NCUBE1; HSPC153; HSPC205; NCUBE-1; HSU93243; MGC12555
    Summary
    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    6q15
    Sequence :
    Chromosome: 6; NC_000006.11 (90036344..90062619, complement)
    See UBE2J1 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid (GABA) A receptor, rho 1 Neighboring gene gamma-aminobutyric acid (GABA) A receptor, rho 2 Neighboring gene tubulin, beta 3 pseudogene Neighboring gene Ras-related GTP binding D Neighboring gene ankyrin repeat domain 6 Neighboring gene LYR motif containing 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation. Burr ML, et al. Proc Natl Acad Sci U S A, 2011 Feb 1. PMID 21245296.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level. Pattaro C, et al. BMC Med Genet, 2010 Mar 11. PMID 20222955.

    See all (19) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. data support a physiological role for HRD1 and UBE2J1 in the homeostatic regulation of MHC class I assembly and expression
      Title: HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation.
    2. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level.
    3. Ubc6e is phosphorylated in response to endoplasmic reticulum stress
      Title: Human homologs of Ubc6p ubiquitin-conjugating enzyme and phosphorylation of HsUbc6e in response to endoplasmic reticulum stress.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_057105.2 NP_001157.1 BIRC2    BIND  PubMed UBE2J1 (hUbc6e), an E2 ubiquitin-conjugating enzyme, interacts with and assists autoubiquitination of BIRC2 (c-IAP1), an E3 ubiquitin-protein ligase. 
    Q9Y385 Q13489 BIRC3    HPRD  PubMed  
    BioGRID:119555 BioGRID:106826 BIRC2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:119555 BioGRID:107140 BRCA1    BioGRID  PubMed Two-hybrid 
    BioGRID:119555 BioGRID:109350 HLA-A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119555 BioGRID:124754 LRSAM1    BioGRID  PubMed Two-hybrid 
    BioGRID:119555 BioGRID:111105 PARK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119555 BioGRID:115200 PJA2    BioGRID  PubMed Two-hybrid 
    BioGRID:119555 BioGRID:111972 RNF2    BioGRID  PubMed Two-hybrid 
    BioGRID:119555 BioGRID:124085 SYVN1    BioGRID  PubMed Two-hybrid 
    BioGRID:119555 BioGRID:115505 TOPORS    BioGRID  PubMed Two-hybrid 
    BioGRID:119555 BioGRID:111919 TRIM27    BioGRID  PubMed Two-hybrid 
    BioGRID:119555 BioGRID:124195 TRIM63    BioGRID  PubMed Two-hybrid 
    BioGRID:119555 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Parkinson's disease, organism-specific biosystem (from KEGG)
      Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic neurons in the substantia nigra. Mutations in alpha-synuclein, UCHL...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin-protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 J1
    Names
    ubiquitin-conjugating enzyme E2 J1
    HSUBC6e
    non-canonical ubiquitin-conjugating enzyme 1
    yeast ubiquitin-conjugating enzyme UBC6 homolog E
    ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
    NP_057105.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016021.2 → NP_057105.2  ubiquitin-conjugating enzyme E2 J1

      Status: REVIEWED

      Source sequence(s)
      AF151834, AJ420522, AJ420578, BC013973, BF058850
      Consensus CDS
      CCDS5021.1
      UniProtKB/Swiss-Prot
      Q9Y385
      Related
      ENSP00000451261, OTTHUMP00000245850, ENST00000435041, OTTHUMT00000043742
      Conserved Domains (1) summary
      cd00195
      Location:12 – 119
      Blast Score: 340
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      90036344..90062619, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      87253169..87279755, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL121833.10 (93587..96522) None
    genomic AL138717.6 CAH70228.1
    genomic AL139804.14 CAI19635.1
    genomic CH471051.2 EAW48555.1
      EAW48556.1
    mRNA AB075487.1 None
    mRNA AF151039.1 AAF36125.1
    mRNA AF151834.1 AAD34071.1
    mRNA AF161502.1 AAF29117.1
    mRNA AJ245898.1 CAB83212.1
    mRNA AJ420479.1 None
    mRNA AJ420522.1 None
    mRNA AJ420578.1 None
    mRNA AJ420600.1 None
    mRNA AK223464.1 BAD97184.1
    mRNA AK290574.1 BAF83263.1
    mRNA AK300629.1 BAG62320.1
    mRNA BC013973.1 AAH13973.1
    mRNA BF058850.1 None
    mRNA U93243.1 AAF21505.1
    other-genetic DQ895144.2 ABM86070.1
    other-genetic EU176317.1 ABW03768.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y385.2 GenPept UniProtKB/Swiss-Prot:Q9Y385
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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