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GULP1 GULP, engulfment adaptor PTB domain containing 1 [ Homo sapiens (human) ]

Gene ID: 51454, updated on 7-Feb-2016
Official Symbol
GULP1provided by HGNC
Official Full Name
GULP, engulfment adaptor PTB domain containing 1provided by HGNC
Primary source
HGNC:HGNC:18649
See related
Ensembl:ENSG00000144366; HPRD:12181; MIM:608165; Vega:OTTHUMG00000132647
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CED6; GULP; CED-6
Summary
The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011]
Orthologs
See GULP1 in Epigenomics, MapViewer
Location:
2q32.3-q33
Exon count:
22
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (188291669..188595926)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (189156396..189460653)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1090 Neighboring gene chromosome 18 open reading frame 25 pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 114 Neighboring gene microRNA 561 Neighboring gene uncharacterized LOC105373789 Neighboring gene uncharacterized LOC105373790 Neighboring gene disrupted in renal carcinoma 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Upregulation of apoptosis genes such as NCK-associated protein 1, PTB domain adaptor protein CED-6, and TNF receptor superfamily 5 are induced by HIV-1 gp120 in human neurons PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ31156

Gene Ontology Provided by GOA

Function Evidence Code Pubs
signal transducer activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
lipid transport IEA
Inferred from Electronic Annotation
more info
 
phagocytosis, engulfment IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
PTB domain-containing engulfment adapter protein 1
Names
PTB domain adapter protein CED-6
PTB domain adaptor protein CED-6
cell death protein 6 homolog
engulfment adapter protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252668.1NP_001239597.1  PTB domain-containing engulfment adapter protein 1 isoform b

    See identical proteins and their annotated locations for NP_001239597.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' end, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC092598, AK055718, AL080142
    Consensus CDS
    CCDS58742.1
    UniProtKB/Swiss-Prot
    Q9UBP9
    Conserved Domains (2) summary
    cd14686
    Location:163195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
  2. NM_001252669.1NP_001239598.1  PTB domain-containing engulfment adapter protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame coding segment compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC092598, AF200715, AK055718, AK298626, AL080142
    Consensus CDS
    CCDS58743.1
    UniProtKB/Swiss-Prot
    Q9UBP9
    Conserved Domains (2) summary
    cd14686
    Location:6092
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cl17171
    Location:3154
    PH-like; Pleckstrin homology-like domain
  3. NM_016315.3NP_057399.1  PTB domain-containing engulfment adapter protein 1 isoform a

    See identical proteins and their annotated locations for NP_057399.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC092598, AF200715, AK055718, AK314498, AL080142
    Consensus CDS
    CCDS2295.1
    UniProtKB/Swiss-Prot
    Q9UBP9
    Conserved Domains (2) summary
    cd14686
    Location:163195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

RNA

  1. NR_045562.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' end compared to variant 1. This variant is thought to be non-protein coding since it contains a 52 aa uORF with a strong Kozak signal in the putative 5' UTR.
    Source sequence(s)
    AC092598, AF200715, AL080142, CD627760, DA392794
  2. NR_045563.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' end compared to variant 1. This variant is thought to be non-protein coding since it contains a 52 aa uORF with a strong Kozak signal in the putative 5' UTR.
    Source sequence(s)
    AC092598, AC104131, AF200715, AL080142, BC068525, CD627760

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    188291669..188595926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511332.1XP_011509634.1  

    Conserved Domains (2) summary
    cd14686
    Location:135167
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:3129
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
  2. XM_006712581.1XP_006712644.1  

    See identical proteins and their annotated locations for XP_006712644.1

    Conserved Domains (2) summary
    cd14686
    Location:163195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
  3. XM_011511333.1XP_011509635.1  

    See identical proteins and their annotated locations for XP_011509635.1

    Conserved Domains (2) summary
    cd14686
    Location:117149
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cl17171
    Location:14111
    PH-like; Pleckstrin homology-like domain
  4. XM_011511330.1XP_011509632.1  

    Conserved Domains (2) summary
    cd14686
    Location:163195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
  5. XM_011511334.1XP_011509636.1  

    Conserved Domains (2) summary
    cd14686
    Location:163195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
  6. XM_011511329.1XP_011509631.1  

    Conserved Domains (2) summary
    cd14686
    Location:163195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
  7. XM_011511335.1XP_011509637.1  

    Conserved Domains (2) summary
    cd14686
    Location:117149
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cl17171
    Location:14111
    PH-like; Pleckstrin homology-like domain
  8. XM_006712589.2XP_006712652.1  

    Conserved Domains (2) summary
    cd14686
    Location:163195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
  9. XM_006712582.1XP_006712645.1  

    See identical proteins and their annotated locations for XP_006712645.1

    Conserved Domains (2) summary
    cd14686
    Location:163195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
  10. XM_011511328.1XP_011509630.1  

    See identical proteins and their annotated locations for XP_011509630.1

    Conserved Domains (2) summary
    cd14686
    Location:163195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
  11. XM_006712580.2XP_006712643.1  

    See identical proteins and their annotated locations for XP_006712643.1

    Conserved Domains (2) summary
    cd14686
    Location:163195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
  12. XM_006712584.2XP_006712647.1  

    See identical proteins and their annotated locations for XP_006712647.1

    Conserved Domains (2) summary
    cd14686
    Location:163195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
  13. XM_006712583.2XP_006712646.1  

    See identical proteins and their annotated locations for XP_006712646.1

    Conserved Domains (2) summary
    cd14686
    Location:163195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
  14. XM_006712590.2XP_006712653.1  

    See identical proteins and their annotated locations for XP_006712653.1

    UniProtKB/Swiss-Prot
    Q9UBP9
    Related
    ENSP00000386289, OTTHUMP00000205909, ENST00000409580, OTTHUMT00000335722
    Conserved Domains (2) summary
    cd14686
    Location:163195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
  15. XM_011511327.1XP_011509629.1  

    See identical proteins and their annotated locations for XP_011509629.1

    Conserved Domains (2) summary
    cd14686
    Location:163195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
  16. XM_006712585.1XP_006712648.1  

    See identical proteins and their annotated locations for XP_006712648.1

    Conserved Domains (2) summary
    cd14686
    Location:163195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
  17. XM_011511331.1XP_011509633.1  

    Conserved Domains (2) summary
    cd14686
    Location:150182
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:5144
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    189162262..189466543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)