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    PDE4D phosphodiesterase 4D, cAMP-specific [ Homo sapiens ]

    Gene ID: 5144, updated on 11-May-2012
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    Summary

    Official Symbol
    PDE4Dprovided by HGNC
    Official Full Name
    phosphodiesterase 4D, cAMP-specificprovided by HGNC
    Primary source
    HGNC:8783
    See related
    Ensembl:ENSG00000113448; HPRD:02530; MIM:600129; Vega:OTTHUMG00000162218
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2; FLJ97311; DKFZp686M11213
    Summary
    This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
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    Genomic context

    Location :
    5q12
    Sequence :
    Chromosome: 5; NC_000005.9 (58264865..59783925, complement)
    Chromosome: 5; NC_000005.9 (58335035..58336614)
    See PDE4D in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene microRNA 548ae-2 Neighboring gene RAB3C, member RAS oncogene family Neighboring gene ribosomal protein L5 pseudogene 15 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa pseudogene Neighboring gene microRNA 582 Neighboring gene ribosomal protein L31 pseudogene 8 Neighboring gene prostate androgen-regulated transcript 1 (non-protein coding) Neighboring gene DEP domain containing 1B Neighboring gene keratin 8 pseudogene 31

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Phosphodiesterase 4 D gene polymorphism in relation to intracranial and extracranial atherosclerosis in ischemic stroke. Kalita J, et al. Dis Markers, 2011. PMID 22045424.
    2. Association of the phosphodiesterase 4D (PDE4D) gene and cardioembolic stroke in an Australian cohort. Milton AG, et al. Int J Stroke, 2011 Dec. PMID 21989204.
    3. Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current. Beca S, et al. Circ Res, 2011 Oct 14. PMID 21903937.
    4. Phosphodiesterase type 4D gene polymorphism: association with the response to short-acting bronchodilators in paediatric asthma patients. Labuda M, et al. Mediators Inflamm, 2011. PMID 21876611.
    5. [Analysis of the polymorphic variants of the PDE4D gene in patients with acute stroke in the Moldavian population]. Bondarenko EA, et al. Mol Gen Mikrobiol Virusol, 2011. PMID 21786629.

    See all (125) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Our findings demonstrated an association between cardioembolic stroke and phosphodiesterase 4D single nucleotide polymorphisms
      Title: Association of the phosphodiesterase 4D (PDE4D) gene and cardioembolic stroke in an Australian cohort.
    2. The frequency of CC genotype of PDE4D83 was significantly higher in the patients with ischemic stroke compared to controls
      Title: Phosphodiesterase 4 D gene polymorphism in relation to intracranial and extracranial atherosclerosis in ischemic stroke.
    3. Results identify new genetic variants of phosphodiesterase type 4D implicated in modulation of asthma treatment, one of them (rs1544791) previously associated with asthma phenotype.
      Title: Phosphodiesterase type 4D gene polymorphism: association with the response to short-acting bronchodilators in paediatric asthma patients.
    4. Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current.
      Title: Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current.
    5. No significant association of the PDE4D with ischemic stroke was observed with SNP41 and 87.
      Title: [Analysis of the polymorphic variants of the PDE4D gene in patients with acute stroke in the Moldavian population].
    6. Decreased beta-agonist induced cAMP in airway smooth muscle from asthmatics results from enhanced degradation due to increased PDE4D expression.
      Title: β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D.
    7. Results reveal novel signalling cross-talk, whereby RACK1 mediates PKC-dependent activation of PDE4D5 in the particulate fraction of HEK-293 cells in response to elevations in intracellular cAMP.
      Title: Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C.
    8. Studies identified phosphodiesterase 4D3 as a direct target of the MSH/cAMP/MITF pathway.
      Title: Control of melanocyte differentiation by a MITF-PDE4D3 homeostatic circuit.
    9. results suggest a novel regulatory mechanism for mTORC1 in which the cAMP-determined dynamic interaction between Rheb and PDE4D provides a key, unique regulatory event, and propose a new role for PDE4 as a molecular transducer for cAMP signaling.
      Title: Cyclic AMP controls mTOR through regulation of the dynamic interaction between Rheb and phosphodiesterase 4D.
    10. PDE4D tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability
      Title: Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability.
    Submit: New GeneRIF Correction See all (70)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    A whole genome association study of neuroticism using DNA pooling.

    Acrodysostosis 2, with or without hormone resistance

    Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.

    Genome-wide association of sleep and circadian phenotypes.

    Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.

    Stroke, susceptibility to, 1

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    AAC00042.1 NP_005148.1 ABL1    BIND  PubMed PDE4D4 interacts with Abl. This interaction was modelled on a demonstrated interaction between human PDE4D4 and abl from an unspecified species. 
    AAC00042.1 NP_002028.1 FYN    BIND  PubMed PDE4D4 interacts with Fyn SH3 domain. 
    AAC00042.1 NP_002077.1 GRB2    BIND  PubMed PDE4D4 interacts with Grb2. This interaction was modelled on a demonstrated interaction between human PDE4D4 and Grb2 from an unspecified species. 
    AAC00042.1 NP_002341.1 LYN    BIND  PubMed PDE4D4 interacts with Lyn SH3 domain. 
    AAC00042.1 NP_002640.2 PIK3CG    BIND  PubMed PDE4D4 interacts with PI3K. This interaction was modelled on a demonstrated interaction between human PDE4D4 and PI3K from an unspecified species. 
    AAC00042.1 NP_003118.1 SPTAN1    BIND  PubMed PDE4D4 interacts with Fodrin. This interaction was modelled on a demonstrated interaction between human PDE4D4 and Fodrin from an unspecified species. 
    AAC00042.1 NP_005408.1 SRC    BIND  PubMed PDE4D4 interacts with Src SH3 domain. 
    AAC00069.1 NP_004032.2 ARRB1    BIND  PubMed The amino-terminus of PDE4D5 interacts with Beta-Arrestin 1. 
    AAC00069.1 NP_004304.1 ARRB2    BIND  PubMed PDE4D5 interacts with Beta-Arrestin 2. 
    AAC00069.1 NP_006089.1 GNB2L1    BIND  PubMed RACK1 interacts with PDE4D5. 
    AAC00069.1     BIND  PubMed Rolipram inhibits the cAMP PDE activity of PDE4D5. 
    Q08499 Q13023 AKAP6    HPRD  PubMed  
    Q08499 P63244 GNB2L1    HPRD  PubMed  
    Q08499 Q08499 PDE4D    HPRD  PubMed  
    Q08499 Phosphodiesterase 4D interacting protein PDE4DIP    HPRD  PubMed  
    Q08499 P17612 PRKACA    HPRD  PubMed  
    BioGRID:111170 BioGRID:114857 AKAP6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111170 BioGRID:106901 ARRB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111170 BioGRID:198404 Bub1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111170 BioGRID:115671 GNB2L1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111170 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111170 BioGRID:111170 PDE4D    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111170 BioGRID:115017 PDE4DIP    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111170 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111170 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • DARPP-32 events, organism-specific biosystem (from REACTOME)
      DARPP-32 events, organism-specific biosystemDopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified as a major target for dopamine and protein kinase A (PKA) in striatum. Recent advances now indicate that regulation D...
    • G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
      G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
    • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Morphine addiction, organism-specific biosystem (from KEGG)
      Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Morphine addiction, conserved biosystem (from KEGG)
      Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Opioid Signalling, organism-specific biosystem (from REACTOME)
      Opioid Signalling, organism-specific biosystemOpioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as...
    • Purine metabolism, organism-specific biosystem (from KEGG)
      Purine metabolism, organism-specific biosystem
      Purine metabolism
    • Purine metabolism, conserved biosystem (from KEGG)
      Purine metabolism, conserved biosystem
      Purine metabolism
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    3',5'-cyclic-AMP phosphodiesterase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    3',5'-cyclic-nucleotide phosphodiesterase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cAMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    drug binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cAMP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    establishment of endothelial barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    insoluble fraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  
    soluble fraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    cAMP-specific 3',5'-cyclic phosphodiesterase 4D
    Names
    cAMP-specific 3',5'-cyclic phosphodiesterase 4D
    cAMP-specific phosphodiesterase PDE4D6
    phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
    NP_001098101.1
    NP_001159371.1
    NP_001184147.1
    NP_001184148.1
    NP_001184149.1
    NP_001184150.1
    NP_001184151.1
    NP_001184152.1
    NP_006194.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027957.1 RefSeqGene

      Range
      5001..1524061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104631.1 → NP_001098101.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (PDE4D4, also known as isoform 1).
      Source sequence(s)
      AC027322, AC092343, BF197530, L20969
      Consensus CDS
      CCDS47213.1
      UniProtKB/Swiss-Prot
      Q08499
      Related
      ENSP00000345502, OTTHUMP00000221595, ENST00000340635, OTTHUMT00000367940
      Conserved Domains (2) summary
      cd00077
      Location:461 – 643
      Blast Score: 127
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
      pfam00233
      Location:461 – 705
      Blast Score: 986
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. NM_001165899.1 → NP_001159371.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D7 (also known as isoform 3) has a shorter and distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC092343, AY245866, BI492585, DB230503
      Consensus CDS
      CCDS54859.1
      UniProtKB/Swiss-Prot
      Q08499
      Related
      ENSP00000423094, OTTHUMP00000221675, ENST00000502484, OTTHUMT00000368094
      Conserved Domains (2) summary
      cd00077
      Location:400 – 582
      Blast Score: 129
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
      pfam00233
      Location:400 – 644
      Blast Score: 985
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. NM_001197218.1 → NP_001184147.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D5 (also known as isoform 4) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC092343, AF012073, BF197530
      Consensus CDS
      CCDS56373.1
      UniProtKB/Swiss-Prot
      Q08499
      Related
      ENSP00000424852, OTTHUMP00000221680, ENST00000507116, OTTHUMT00000368103
      Conserved Domains (2) summary
      cd00077
      Location:397 – 579
      Blast Score: 130
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
      pfam00233
      Location:397 – 641
      Blast Score: 984
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    4. NM_001197219.1 → NP_001184148.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D8 (also known as isoform 5) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC008791, AC092343, AF012073, AF536977, BF197530
      Consensus CDS
      CCDS56372.1
      UniProtKB/Swiss-Prot
      Q08499
      Related
      ENSP00000384806, OTTHUMP00000221683, ENST00000405755, OTTHUMT00000368106
      Conserved Domains (2) summary
      cd00077
      Location:339 – 521
      Blast Score: 130
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
      pfam00233
      Location:339 – 583
      Blast Score: 988
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    5. NM_001197220.1 → NP_001184149.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D9 (also known as isoform 6) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC092343, AF012073, AY245867, BF197530
      Consensus CDS
      CCDS56371.1
      UniProtKB/Swiss-Prot
      Q08499
      Related
      ENSP00000425605, OTTHUMP00000221684, ENST00000503258, OTTHUMT00000368107
      Conserved Domains (2) summary
      cd00077
      Location:331 – 513
      Blast Score: 129
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
      pfam00233
      Location:331 – 575
      Blast Score: 982
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    6. NM_001197221.1 → NP_001184150.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D2 (also known as isoform 7) is shorter at the N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC092343, AF012074, BF197530
      Consensus CDS
      CCDS56370.1
      UniProtKB/Swiss-Prot
      Q08499
      Related
      ENSP00000351800, OTTHUMP00000221686, ENST00000358923, OTTHUMT00000368110
      Conserved Domains (2) summary
      cd00077
      Location:159 – 341
      Blast Score: 122
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
      pfam00233
      Location:159 – 403
      Blast Score: 972
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    7. NM_001197222.1 → NP_001184151.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D1 (also known as isoform 8) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC092343, AF012074, BF197530, U50157
      UniProtKB/Swiss-Prot
      Q08499
      Conserved Domains (2) summary
      cd00077
      Location:237 – 419
      Blast Score: 126
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
      pfam00233
      Location:237 – 481
      Blast Score: 982
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    8. NM_001197223.1 → NP_001184152.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D6 (also known as isoform 9) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC092343, AF536975, BC036319, BF197530
      Consensus CDS
      CCDS56369.1
      UniProtKB/Swiss-Prot
      Q08499
      Related
      ENSP00000321739, OTTHUMP00000221687, ENST00000317118, OTTHUMT00000368111
      Conserved Domains (2) summary
      cd00077
      Location:170 – 352
      Blast Score: 123
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
      pfam00233
      Location:170 – 414
      Blast Score: 976
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    9. NM_006203.4 → NP_006194.2  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D3 (also known as isoform 2) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC092343, BF197530, L20970, U50159
      Consensus CDS
      CCDS54858.1
      UniProtKB/Swiss-Prot
      Q08499
      Related
      ENSP00000353152, OTTHUMP00000221682, ENST00000360047, OTTHUMT00000368105
      Conserved Domains (2) summary
      cd00077
      Location:325 – 507
      Blast Score: 128
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
      pfam00233
      Location:325 – 569
      Blast Score: 979
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9

      Range
      58264865..59783925, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_108601.1 RNA Sequence

    Alternate HuRef

    Genomic

    1. AC_000137.1

      Range
      55222770..56741723, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_112733.1 RNA Sequence

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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC008791.5 None
    genomic AC008804.7 (14746..133475) None
    genomic AC008818.7 (26700..152684) None
    genomic AC008829.7 None
    genomic AC008833.5 None
    genomic AC008934.5 None
    genomic AC012315.5 None
    genomic AC020924.8 None
    genomic AC026693.5 None
    genomic AC027322.4 None
    genomic AC034234.4 None
    genomic AC091913.2 None
    genomic AC091955.2 None
    genomic AC092343.3 None
    genomic AC109486.2 (5749..202404) None
    genomic AC117527.2 None
    genomic CH471123.1 EAW54982.1
      EAW54983.1
      EAW54984.1
      EAW54985.1
      EAW54986.1
      EAW54987.1
      EAW54988.1
      EAW54989.1
      EAW54990.1
      EAW54991.1
      EAW54992.1
    mRNA AF012073.1 AAC00069.1
    mRNA AF012074.1 AAC00070.1
    mRNA AF536975.1 AAN10117.1
    mRNA AF536976.1 AAN10118.1
    mRNA AF536977.1 AAN10119.1
    mRNA AF536980.1 None
    mRNA AJ250852.1 CAC03756.1
    mRNA AJ250854.1 CAC03757.1
    mRNA AJ250855.1 CAC03758.1
    mRNA AK307363.1 None
    mRNA AY245866.1 AAP75760.1
    mRNA AY245867.1 AAP75761.1
    mRNA AY388960.1 AAQ90404.1
    mRNA BC008390.1 AAH08390.1
    mRNA BC036319.1 AAH36319.1
    mRNA BF197530.1 None
    mRNA BI492585.1 None
    mRNA BT007398.1 AAP36062.1
    mRNA BX648604.1 None
    mRNA DB230503.1 None
    mRNA L20970.1 AAA03592.1
    mRNA U02882.1 AAC13745.1
    mRNA U50157.1 AAA97890.1
    mRNA U50158.1 AAA97891.1
    mRNA U50159.1 AAA97892.1
    mRNA U79571.1 AAC51928.1
    other-genetic JF432192.1 ADZ15409.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43862 GenPept UniProtKB/TrEMBL:O43862
    Q08499.2 GenPept UniProtKB/Swiss-Prot:Q08499
    Q9HCX6 GenPept UniProtKB/TrEMBL:Q9HCX6
    Q9HCX8 GenPept UniProtKB/TrEMBL:Q9HCX8
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