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MAGEC2 MAGE family member C2 [ Homo sapiens (human) ]

Gene ID: 51438, updated on 8-May-2016
Official Symbol
MAGEC2provided by HGNC
Official Full Name
MAGE family member C2provided by HGNC
Primary source
HGNC:HGNC:13574
See related
Ensembl:ENSG00000046774 HPRD:06632; MIM:300468; Vega:OTTHUMG00000022574
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT10; HCA587; MAGEE1
Summary
This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009]
Orthologs
Location:
Xq27
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (142202342..142205290, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (141290128..141293076, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MAGE family member C3 pseudogene Neighboring gene MAGE family member C2 pseudogene Neighboring gene MAGE family member C3 pseudogene Neighboring gene zinc finger MYM-type containing 1 pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 516

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetically distinct subsets within ANCA-associated vasculitis.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC13377

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
melanoma-associated antigen C2
Names
MAGE-C2 antigen
MAGE-E1 antigen
cancer/testis antigen 10
hepatocellular cancer antigen 587
hepatocellular carcinoma-associated antigen 587
melanoma antigen family C, 2
melanoma antigen family C2
melanoma antigen, family E, 1, cancer/testis specific

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015872.1 RefSeqGene

    Range
    5001..7949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016249.3NP_057333.1  melanoma-associated antigen C2

    See identical proteins and their annotated locations for NP_057333.1

    Status: REVIEWED

    Source sequence(s)
    AF116194, BC005891, BC013318, BM548987, BP370466
    Consensus CDS
    CCDS14678.1
    UniProtKB/Swiss-Prot
    Q9UBF1
    Related
    ENSP00000354660, OTTHUMP00000024186, ENST00000247452, OTTHUMT00000058611
    Conserved Domains (1) summary
    pfam01454
    Location:148314
    MAGE; MAGE family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    142202342..142205290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    141201271..141204219 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)