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    ANAPC7 anaphase promoting complex subunit 7 [ Homo sapiens ]

    Gene ID: 51434, updated on 19-May-2012
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    Summary

    Official Symbol
    ANAPC7provided by HGNC
    Official Full Name
    anaphase promoting complex subunit 7provided by HGNC
    Primary source
    HGNC:17380
    See related
    Ensembl:ENSG00000196510; HPRD:16233; MIM:606949; Vega:OTTHUMG00000157009
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APC7
    Summary
    This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
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    Genomic context

    Location :
    12q24.11
    Sequence :
    Chromosome: 12; NC_000012.11 (110810705..110841535, complement)
    See ANAPC7 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 81 homolog (Chlamydomonas) Neighboring gene ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Neighboring gene high mobility group AT-hook 1 pseudogene 3 Neighboring gene actin related protein 2/3 complex, subunit 3, 21kDa

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner. Lara-Gonzalez P, et al. J Cell Sci, 2011 Dec 15. PMID 22193957.
    2. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    3. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Mansfeld J, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926987.
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.

    See all (47) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Studies indicate that APC/C(Cdh1) is required to maintain genomic stability.
      Title: The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.
    2. The crystal structure of quad mutant of nApc7 (N-terminal fragment, residues 1-147) of human Apc7 at a resolution of 2.5 A, is reported.
      Title: Crystal structure of the N-terminal domain of anaphase-promoting complex subunit 7.
    3. Expression of ANAPC7 in fibroadenomas and phylloides tumors of breast is reported.
      Title: Expression of anaphase-promoting complex7 in fibroadenomas and phyllodes tumors of breast.
    4. APC5 and APC7 suppress E1A-mediated transformation in a CBP/p300-dependent manner, indicating that these components of the APC/C may be targeted during cellular transformation
      Title: The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression.
    5. dysregulation of APC activity, possibly through downregulation of APC7, may be associated with tumorigenesis in breast cancer
      Title: Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9UJX3 Q9UM13 ANAPC10    HPRD  PubMed  
    Q9UJX3 Q9UJX6 ANAPC2    HPRD  PubMed  
    Q9UJX3 O60566 BUB1B    HPRD  PubMed  
    Q9UJX3 Q13042 CDC16    HPRD  PubMed  
    Q9UJX3 Q12834 CDC20    HPRD  PubMed  
    Q9UJX3 P30260 CDC27    HPRD  PubMed  
    Q9UJX3 P12830 CDH1    HPRD  PubMed  
    BioGRID:119538 BioGRID:122229 ANAPC1    BioGRID  PubMed Co-purification; Reconstituted Complex 
    BioGRID:119538 BioGRID:118982 ANAPC4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:119538 BioGRID:119537 ANAPC5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119538 BioGRID:115585 APC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119538 BioGRID:201352 Anapc1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119538 BioGRID:213171 Anapc13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119538 BioGRID:206755 Anapc16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119538 BioGRID:221196 Anapc2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119538 BioGRID:208479 Anapc5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119538 BioGRID:113911 BAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119538 BioGRID:107166 BUB1B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:119538 BioGRID:198405 Bub1b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119538 BioGRID:107332 CCNB1    BioGRID  PubMed Biochemical Activity 
    BioGRID:119538 BioGRID:114400 CDC16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119538 BioGRID:107427 CDC20    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:119538 BioGRID:107431 CDC27    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:119538 BioGRID:107434 CDH1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119538 BioGRID:123555 CDT1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:119538 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:119538 BioGRID:213776 Cdc16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119538 BioGRID:223749 Cdc20    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119538 BioGRID:206665 Cdc23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119538 BioGRID:198624 Cdk1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119538 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119538 BioGRID:119489 FZR1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119538 BioGRID:580243 Gm9174    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119538 BioGRID:207818 Mad2l1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119538 BioGRID:114663 PTTG1    BioGRID  PubMed Biochemical Activity 
    BioGRID:119538 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119538 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119538 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119538 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the ANAPC7 gene: The ANAPC7 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • APC/C complex, organism-specific biosystem (from KEGG)
      APC/C complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • APC/C complex, conserved biosystem (from KEGG)
      APC/C complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
    • APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
      APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
    • APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystemThe degradation of cyclin B1, which appears to occur at the mitotic spindle, is delayed until the metaphase /anaphase transition by the spindle assembly checkpoint and is required in order for sister...
    • APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystemThe separation of sister chromatids in anaphase requires the destruction of the anaphase inhibitor, securin. Securin associates with and inactivates the protease, separase. Separase cleaves the cohe...
    • APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemFollowing phosphorylation of the APC/C core subunits by mitotic kinases, the activating protein, Cdc20 is recruited to the APC and promotes the multiubiquitination and subsequent degradation of the ...
    • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem (from REACTOME)
      APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystemFrom late mitosis through G1 phase APC/C:Cdh1 insures the continued degradation of the mitotic proteins and during mitotic exit and G1 its substrates include Cdc20, Plk1, Aurora A, Cdc6 and Gemin...
    • Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
      Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemAPC/C:Cdc20 is first activated at the prometaphase/metaphase transition through phosphorylation of core subunits of the APC/C by mitotic kinases as well as recruitment of the APC/C activator protein ...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Autodegradation of Cdh1 by Cdh1:APC/C, organism-specific biosystem (from REACTOME)
      Autodegradation of Cdh1 by Cdh1:APC/C, organism-specific biosystemCdh1 is degraded by the APC/C during in G1 and G0. This auto-regulation may contribute to reducing the levels of Cdh1 levels during G1 and G0 (Listovsky et al., 2004).
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, organism-specific biosystem (from REACTOME)
      Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, organism-specific biosystemThe activity of the APC/C must be appropriately regulated during the cell cycle to ensure the timely degradation of its substrates. Of particular importance is the conversion from APC/C:Cdc20 to APC...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inactivation of APC/C via direct inhibition of the APC/C complex, organism-specific biosystem (from REACTOME)
      Inactivation of APC/C via direct inhibition of the APC/C complex, organism-specific biosystemIn the direct inhibition model, the cytosolic Mitotic Checkpoint Complex, consisting of hBUBR1, hBUB3, Cdc20 and Mad2, directly inhibits APC/C by binding to it.
    • Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, organism-specific biosystem (from REACTOME)
      Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, organism-specific biosystemThe target of the mitotic checkpoint is the Anaphase Promoting Complex/Cyclosome (APC/C) an E3 ubiquitin ligase that targets proteins whose destruction is essential for mitotic exit. Currently, there...
    • Mitotic Spindle Checkpoint, organism-specific biosystem (from REACTOME)
      Mitotic Spindle Checkpoint, organism-specific biosystemThe mitotic checkpoint or spindle assembly checkpoint is an evolutionarily conserved mechanism that ensures that cells with misaligned chromosomes do not exit mitosis and divide to form aneuploid cel...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Phosphorylation of the APC/C, organism-specific biosystem (from REACTOME)
      Phosphorylation of the APC/C, organism-specific biosystemPhosphorylation of APC subunits is required for Cdc20 mediated activation by of the APC/C at the metaphase anaphase transition (Kramer et al., 2000). While the kinases responsible for phosphorylation...
    • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
      Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemThe APC/C is activated by either Cdc20 or Cdh1. While both activators associate with the APC/C, they do so at different points in the cell cycle and their binding is regulated differently (see Zacha...
    • Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
      Regulation of mitotic cell cycle, organism-specific biosystem
      Regulation of mitotic cell cycle
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		  
    cell cycle checkpoint TAS
    Traceable Author Statement
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    mitotic cell cycle spindle assembly checkpoint TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
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    General protein information

    Preferred Names
    anaphase-promoting complex subunit 7
    Names
    anaphase-promoting complex subunit 7
    cyclosome subunit 7
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001137664.1 → NP_001131136.1  anaphase-promoting complex subunit 7 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region (compared to variant 1), which results in a frameshift. It encodes isoform b which has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      BC040130, BG105587, DB003237
      Consensus CDS
      CCDS44971.1
      UniProtKB/Swiss-Prot
      Q9UJX3
      Related
      ENSP00000402314, OTTHUMP00000211291, ENST00000450008, OTTHUMT00000347076
      Conserved Domains (2) summary
      cd00189
      Location:346 – 426
      Blast Score: 111
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      TIGR02917
      Location:133 – 426
      Blast Score: 99
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

    2. NM_016238.2 → NP_057322.2  anaphase-promoting complex subunit 7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL157481, BC098362, DB003237
      Consensus CDS
      CCDS9145.2
      UniProtKB/TrEMBL
      Q4KMX6
      UniProtKB/TrEMBL
      Q69YV3
      UniProtKB/Swiss-Prot
      Q9UJX3
      Related
      ENSP00000394394, OTTHUMP00000211290, ENST00000455511, OTTHUMT00000347075
      Conserved Domains (3) summary
      cd00189
      Location:346 – 426
      Blast Score: 111
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      TIGR02917
      Location:133 – 426
      Blast Score: 99
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      pfam13432
      Location:481 – 542
      Blast Score: 89
      TPR_16; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      110810705..110841535, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      107829309..107860504, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC144548.8 (52084..81567) None
    genomic CH471054.1 EAW97909.1
      EAW97910.1
      EAW97911.1
    mRNA AF191340.1 AAF05754.1
    mRNA AK021809.1 BAG51054.1
    mRNA AL137586.1 CAB70828.1
    mRNA AL157481.1 CAH10690.2
    mRNA AY007104.1 None
    mRNA BC002941.2 AAH02941.2
    mRNA BC009498.2 AAH09498.2
    mRNA BC017316.2 AAH17316.2
    mRNA BC040130.1 None
    mRNA BC098264.1 AAH98264.1
    mRNA BC098295.1 AAH98295.1
    mRNA BC098362.1 AAH98362.1
    mRNA BC099732.1 AAH99732.1
    mRNA BC111798.1 AAI11799.1
    mRNA BC141848.1 AAI41849.1
    mRNA BC148236.2 AAI48237.1
    mRNA BG105587.1 None
    mRNA DB003237.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2M2R1 GenPept UniProtKB/TrEMBL:Q2M2R1
    Q4KMX6 GenPept UniProtKB/TrEMBL:Q4KMX6
    Q69YV3 GenPept UniProtKB/TrEMBL:Q69YV3
    Q9UJX3.4 GenPept UniProtKB/Swiss-Prot:Q9UJX3
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

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