Format

Send to:

Choose Destination

PDE4C phosphodiesterase 4C [ Homo sapiens (human) ]

Gene ID: 5143, updated on 8-May-2016
Official Symbol
PDE4Cprovided by HGNC
Official Full Name
phosphodiesterase 4Cprovided by HGNC
Primary source
HGNC:HGNC:8782
See related
Ensembl:ENSG00000105650 HPRD:02529; MIM:600128; Vega:OTTHUMG00000183353
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPDE1
Summary
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Orthologs
Location:
19p13.11
Exon count:
20
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (18207961..18248200, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18318771..18359010, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RAB3A, member RAS oncogene family Neighboring gene uncharacterized LOC102725254 Neighboring gene uncharacterized LOC729966 Neighboring gene KIAA1683

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat Cyclic AMP phosphodiesterase inhibitors AV411 and AV1013 inhibit HIV-1 replication and block HIV-1 Tat-induced neurotoxicity in human microglia, suggesting that cyclic AMP phosphodiesterase is involved in the Tat-mediated neurotoxicity PubMed
tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed

Go to the HIV-1, Human Interaction Database

  • DARPP-32 events, organism-specific biosystem (from REACTOME)
    DARPP-32 events, organism-specific biosystemDopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified as a major target for dopamine and protein kinase A (PKA) in striatum. Recent advances now indicate that regulation D...
  • G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
    G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Morphine addiction, organism-specific biosystem (from KEGG)
    Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Morphine addiction, conserved biosystem (from KEGG)
    Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Opioid Signalling, organism-specific biosystem (from REACTOME)
    Opioid Signalling, organism-specific biosystemOpioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as...
  • Purine metabolism, organism-specific biosystem (from KEGG)
    Purine metabolism, organism-specific biosystem
    Purine metabolism
  • Purine metabolism, conserved biosystem (from KEGG)
    Purine metabolism, conserved biosystem
    Purine metabolism
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC126222

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3',5'-cyclic-AMP phosphodiesterase activity TAS
Traceable Author Statement
more info
 
drug binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
primary cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Names
PDE21
phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)
phosphodiesterase E1 dunce homolog
NP_000914.2
NP_001092288.1
NP_001092289.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029629.1 RefSeqGene

    Range
    5001..45240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000923.4NP_000914.2  cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform PDE4C1

    See identical proteins and their annotated locations for NP_000914.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (PDE4C1).
    Source sequence(s)
    AC068499, AI051127, BC109067, DB313915, L20968, U66346, Z46632
    Consensus CDS
    CCDS12373.1
    UniProtKB/Swiss-Prot
    Q08493
    UniProtKB/TrEMBL
    O43849, Q32MM7
    Related
    ENSP00000469696, OTTHUMP00000271520, ENST00000594617, OTTHUMT00000466298
    Conserved Domains (1) summary
    cd00077
    Location:387569
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
  2. NM_001098818.2NP_001092288.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform PDE4C3

    See identical proteins and their annotated locations for NP_001092288.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon compared to variant 1. This results in a shorter isoform (PDE4C3) with a distinct N-terminus compared to isoform PDE4C1.
    Source sequence(s)
    AC005759, AC068499, AI051127, BC109067, DB313915, L20968, U88713, Z46632
    Consensus CDS
    CCDS42523.1
    UniProtKB/Swiss-Prot
    Q08493
    UniProtKB/TrEMBL
    P78505, Q32MM7
    Related
    ENSP00000262805, OTTHUMP00000271522, ENST00000262805, OTTHUMT00000466301
    Conserved Domains (1) summary
    cd00077
    Location:355537
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
  3. NM_001098819.2NP_001092289.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform PDE4C2

    See identical proteins and their annotated locations for NP_001092289.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (PDE4C2) with a shorter N-terminus compared to isoform PDE4C1.
    Source sequence(s)
    AC068499, AI051127, BC109067, DB313915, L20968, U88712, Z46632
    Consensus CDS
    CCDS46016.1
    UniProtKB/Swiss-Prot
    Q08493
    UniProtKB/TrEMBL
    Q32MM7, Q7KYS4
    Related
    ENSP00000402091, OTTHUMP00000271519, ENST00000447275, OTTHUMT00000466296
    Conserved Domains (1) summary
    cd00077
    Location:281463
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

RNA

  1. NR_040546.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon, and is missing an internal exon compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF (with a strong Kozak signal) that is predicted to interfere with the translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005759, AC068499, AI051127, BC109067, DB313915, L20968, U88713, Z46632

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    18207961..18248200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528056.1XP_011526358.1  

    See identical proteins and their annotated locations for XP_011526358.1

    UniProtKB/Swiss-Prot
    Q08493
    Conserved Domains (1) summary
    cd00077
    Location:281463
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
  2. XM_011528058.1XP_011526360.1  

    See identical proteins and their annotated locations for XP_011526360.1

    UniProtKB/TrEMBL
    Q32MM7
    Related
    ENSP00000439470, ENST00000539010
    Conserved Domains (1) summary
    cd00077
    Location:156338
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
  3. XM_011528057.1XP_011526359.1  

    Conserved Domains (1) summary
    cd00077
    Location:387511
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    18318324..18358516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)