SNX9 sorting nexin 9 [Homo sapiens] - Gene

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Summary

Official Symbol: SNX9provided by HGNC
Official Full Name: sorting nexin 9provided by HGNC
Primary source: HGNC:14973
Locus tag: RP11-266C7.10-001
See related: Ensembl:ENSG00000130340; HPRD:12072; MIM:605952; Vega:OTTHUMG00000015903
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SDP1; WISP; MST155; SH3PX1; MSTP155; SH3PXD3A
Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain a SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 6q25.1-q26

Sequence :: Chromosome: 6; NC_000006.11 (158244294..158366109)

See SNX9 in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study identifies critical amino acids within the BAR domains of SNX9 and SNX33 as determinants for the specificity of BAR domain-mediated interactions and suggests that SNX9 and SNX33 have distinct molecular functions.
Title: Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33.
Findings suggest that EspF promotes EPEC invasion of intestinal epithelial cells by harnessing the membrane-deforming activity of SNX9.
Title: E. coli secreted protein F promotes EPEC invasion of intestinal epithelial cells via an SNX9-dependent mechanism.
The interaction with SNX9 is mediated by the proline-rich domain (PRD) of Itch, a domain distinct from the conventional WW recognition domain, and the SH3 domain of SNX9.
Title: The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
SNX9 binding to aldolase is structurally precluded by the binding of substrate to the active site.
Title: Mechanism of aldolase control of sorting nexin 9 function in endocytosis.
Tip-to-tip interactions between the BAR domains in a trigonal crystal form of Snx9(PX-BAR) reminiscent of functionally important interactions described for F-BAR domains.
Title: Structure and plasticity of Endophilin and Sorting Nexin 9.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genes to diseases (G2D) computational method to identify asthma candidate genes.
SNX9 functions in the coordination of membrane remodeling and fission via interactions with actin-regulating proteins, endocytic proteins and PtdIns(4,5)P2-metabolizing enzymes
Title: SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2.
crystallization and x-ray diffraction of SNX9
Title: A combinatorial approach to crystallization of PX-BAR unit of the human Sorting Nexin 9.
SNX9 PX and BAR domains work in concert in targeting and tubulation of phosphoinositide-containing membranes.
Title: The PX-BAR membrane-remodeling unit of sorting nexin 9.

Submit: New GeneRIF Correction See all (20)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q9Y5X1	Q13444	ADAM15	HPRD	PubMed
Q9Y5X1	Q13443	ADAM9	HPRD	PubMed
Q9Y5X1	Q00610	CLTC	HPRD	PubMed
Q9Y5X1	Q05193	DNM1	HPRD	PubMed
Q9Y5X1	P50570	DNM2	HPRD	PubMed
Q9Y5X1	Q99547	MPHOSPH6	HPRD	PubMed
Q9Y5X1	Q9NZW5	MPP6	HPRD	PubMed
Q9Y5X1	Q13177	PAK2	HPRD	PubMed
Q9Y5X1	Q07889	SOS1	HPRD	PubMed
Q9Y5X1	Q07890	SOS2	HPRD	PubMed
Q9Y5X1	Q07912	TNK2	HPRD	PubMed
BioGRID:119535	BioGRID:114287	ADAM15	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:119535	BioGRID:114290	ADAM9	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:119535	BioGRID:107623	CLTC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:119535	BioGRID:108122	DNM2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:119535	BioGRID:123747	ITCH	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:119535	BioGRID:119675	MPP6	BioGRID	PubMed	Two-hybrid
BioGRID:119535	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western

Function	Evidence Code	Pubs
1-phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
lipid binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info

Process	Evidence Code	Pubs
cell communication	IEA Inferred from Electronic Annotation more info
intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
lipid tube assembly	IDA Inferred from Direct Assay more info	PubMed
positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein oligomerization	IDA Inferred from Direct Assay more info	PubMed
receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
colocalizes_with clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoplasmic membrane-bounded vesicle	IDA Inferred from Direct Assay more info	PubMed
cytoplasmic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
extrinsic to internal side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
intracellular	IMP Inferred from Mutant Phenotype more info	PubMed
plasma membrane	IEA Inferred from Electronic Annotation more info
ruffle	IEA Inferred from Electronic Annotation more info
trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: sorting nexin-9

Names: sorting nexin-9; SH3 and PX domain-containing protein 1; SH3 and PX domain-containing protein 3A; SH3 and PX domain-containing protein SH3PX1; Wiskott-Aldrich syndrome protein (WASP) interactor protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016224.3 → NP_057308.1 sorting nexin-9

Status: REVIEWED

Source sequence(s)

AF172847, BG766499

Consensus CDS

CCDS5253.1

UniProtKB/Swiss-Prot

Q9Y5X1

Related

ENSP00000376024, OTTHUMP00000017492, ENST00000392185, OTTHUMT00000042856

Conserved Domains (3) summary

cd00174
Location:4 – 59
Blast Score: 146

SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

cd07285
Location:250 – 375
Blast Score: 705

PX_SNX9; The phosphoinositide binding Phox Homology domain of Sorting Nexin 9

cd07668
Location:386 – 595
Blast Score: 1131

BAR_SNX9; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 9

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p5 Primary Assembly

Range

158244294..158366109

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

155760951..155838449

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL035634.7	CAI20465.1
genomic	AL139330.17	CAI12979.1
genomic	AL391863.21	CAI15180.1
genomic	CH471051.2	EAW47668.1
		EAW47669.1
mRNA	AB209736.1	BAD92973.1
mRNA	AF001629.1	AAD00898.1
mRNA	AF076957.1	AAD43001.1
mRNA	AF121859.1	AAD27832.1
mRNA	AF131214.1	AAF04473.1
mRNA	AF172847.1	AAL54871.1
mRNA	AF190158.1	AAQ13702.1
mRNA	AJ420452.1	None
mRNA	AJ420512.1	None
mRNA	AK026637.1	None
mRNA	AK127345.1	BAG54490.1
mRNA	AK314360.1	BAG36992.1
mRNA	BC001084.2	AAH01084.3
mRNA	BC005022.1	AAH05022.1
mRNA	BG766499.1	None
other-genetic	DQ893300.2	ABM84226.1
other-genetic	DQ896789.2	ABM87788.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O95061	GenPept	UniProtKB/TrEMBL:O95061
Q59ES5	GenPept	UniProtKB/TrEMBL:Q59ES5
Q7Z4B8	GenPept	UniProtKB/TrEMBL:Q7Z4B8
Q9Y5X1.1	GenPept	UniProtKB/Swiss-Prot:Q9Y5X1