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DDX41 DEAD-box helicase 41 [ Homo sapiens (human) ]

Gene ID: 51428, updated on 26-May-2016
Official Symbol
DDX41provided by HGNC
Official Full Name
DEAD-box helicase 41provided by HGNC
Primary source
HGNC:HGNC:18674
See related
Ensembl:ENSG00000183258 HPRD:10490; MIM:608170; Vega:OTTHUMG00000130858
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ABS; MPLPF
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression. [provided by RefSeq, Jul 2008]
Orthologs
Location:
5q35.3
Exon count:
17
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (177511577..177516966, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176938578..176943967, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene PDZ and LIM domain 7 Neighboring gene docking protein 3 Neighboring gene family with sequence similarity 193 member B Neighboring gene uncharacterized LOC105377750

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cytosolic sensors of pathogen-associated DNA, organism-specific biosystem (from REACTOME)
    Cytosolic sensors of pathogen-associated DNA, organism-specific biosystemPresence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon ...
  • IRF3-mediated induction of type I IFN, organism-specific biosystem (from REACTOME)
    IRF3-mediated induction of type I IFN, organism-specific biosystemTANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3) are central regulators of type-I interferon induction during bacterial or viral infection. TBK1 was found to form complexes with...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Regulation of innate immune responses to cytosolic DNA, organism-specific biosystem (from REACTOME)
    Regulation of innate immune responses to cytosolic DNA, organism-specific biosystemInnate immune responses are coordinated and regulated to provide an efficient first line of defense against pathogens and at the same time to prevent host self-damage. Here we present some regulatory...
  • STING mediated induction of host immune responses, organism-specific biosystem (from REACTOME)
    STING mediated induction of host immune responses, organism-specific biosystemSTING (stimulator of IFN genes; also known as MITA/ERIS/MPYS/TMEM173) is an endoplasmic reticulum (ER) resident, which is required for effective type I IFN production in response to nucleic acids. In...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC8828

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA processing TAS
Traceable Author Statement
more info
PubMed 
RNA secondary structure unwinding IBA
Inferred from Biological aspect of Ancestor
more info
 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cellular response to interferon-beta IEA
Inferred from Electronic Annotation
more info
 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
regulation of type I interferon production TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
probable ATP-dependent RNA helicase DDX41
Names
2900024F02Rik
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
DEAD box protein 41
DEAD box protein abstrakt homolog
DEAD-box protein abstrakt
putative RNA helicase
NP_057306.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046846.1 RefSeqGene

    Range
    5001..10750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321732.1NP_001308661.1  probable ATP-dependent RNA helicase DDX41 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK091545, AK091774, BC015476
    Conserved Domains (3) summary
    smart00487
    Location:70283
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:283409
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:57271
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
  2. NM_001321830.1NP_001308759.1  probable ATP-dependent RNA helicase DDX41 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK091545, BC015476, DB039560
    Conserved Domains (3) summary
    smart00487
    Location:70283
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:283409
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:57271
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
  3. NM_016222.3NP_057306.2  probable ATP-dependent RNA helicase DDX41 isoform 1

    See identical proteins and their annotated locations for NP_057306.2

    Status: REVIEWED

    Source sequence(s)
    AK091545, BC015476
    Consensus CDS
    CCDS4427.1
    UniProtKB/Swiss-Prot
    Q9UJV9
    Related
    ENSP00000422753, OTTHUMP00000161451, ENST00000507955, OTTHUMT00000253432
    Conserved Domains (3) summary
    smart00487
    Location:196409
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:409535
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:183397
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    177511577..177516966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714870.1XP_006714933.1  

    UniProtKB/TrEMBL
    B3KRK2
    Conserved Domains (3) summary
    smart00487
    Location:70283
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:283409
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:57271
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    176371520..176376909 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)