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BCO2 beta-carotene oxygenase 2 [ Bos taurus (cattle) ]

Gene ID: 514135, updated on 5-Mar-2024

Summary

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Official Symbol
BCO2provided by VGNC
Official Full Name
beta-carotene oxygenase 2provided by VGNC
Primary source
VGNC:VGNC:26454
See related
BGD:BT25733; Ensembl:ENSBTAG00000034193
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
BCDO2
Orthologs
human mouse all
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Genomic context

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See BCO2 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (22513068..22580768)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene interleukin 18 Neighboring gene testis expressed 12 Neighboring gene endogenous retrovirus group PABLB member 1 Env polyprotein-like Neighboring gene 6-pyruvoyltetrahydropterin synthase Neighboring gene chromosome 15 open reading frame, human C11orf34

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutation in bovine beta-carotene oxygenase 2 affects milk color. Berry SD, et al. Genetics, 2009 Jul. PMID 19398771, Free PMC Article
  2. Genetic variation in the beta, beta-carotene-9', 10'-dioxygenase gene and association with fat colour in bovine adipose tissue and milk. Tian R, et al. Anim Genet, 2010 Jun. PMID 19968649
  3. Association between CSN3 and BCO2 gene polymorphisms and milk performance traits in the Czech Fleckvieh cattle breed. Bartonova P, et al. Genet Mol Res, 2012 Apr 27. PMID 22614274
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BCO2 gene (genotypes AA and AG) shows a statistically significant relationship (P = 0.05) with daily milk, protein yield and SCC
    Title: Association between CSN3 and BCO2 gene polymorphisms and milk performance traits in the Czech Fleckvieh cattle breed.
  2. Animals with the BCO2 AA genotype had more yellow beef fat and a higher beta-carotene concentration in adipose tissues than those with the GA or GG genotype.
    Title: Genetic variation in the beta, beta-carotene-9', 10'-dioxygenase gene and association with fat colour in bovine adipose tissue and milk.
  3. The BCO2 enzyme is identified as a key regulator of beta-carotene metabolism.
    Title: Mutation in bovine beta-carotene oxygenase 2 affects milk color.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC179481

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables beta-carotene 15,15'-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables carotenoid dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in carotene catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in retinal metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
carotenoid-cleaving dioxygenase, mitochondrial
Names
beta-carotene dioxygenase 2
NP_001095457.2
XP_024830985.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101987.2 → NP_001095457.2  carotenoid-cleaving dioxygenase, mitochondrial

    See identical proteins and their annotated locations for NP_001095457.2

    Status: VALIDATED

    Source sequence(s)
    BC151703, DN641444
    UniProtKB/TrEMBL
    A0A5F2P3E3, A0A8J8XZT1, A7E341, F1N2Z9, V6F7Q8
    Related
    ENSBTAP00000100568.1, ENSBTAT00000089409.1
    Conserved Domains (1) summary
    pfam03055
    Location:62 → 574
    RPE65; Retinal pigment epithelial membrane protein

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    22513068..22580768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024975217.2 → XP_024830985.1  carotenoid-cleaving dioxygenase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A7E341
    Related
    ENSBTAP00000045443.4, ENSBTAT00000048395.4
    Conserved Domains (1) summary
    pfam03055
    Location:63 → 538
    RPE65; Retinal pigment epithelial membrane protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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