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    UCHL5 ubiquitin carboxyl-terminal hydrolase L5 [ Homo sapiens ]

    Gene ID: 51377, updated on 11-May-2012

    Summary

    Official Symbol
    UCHL5provided by HGNC
    Official Full Name
    ubiquitin carboxyl-terminal hydrolase L5provided by HGNC
    Primary source
    HGNC:19678
    Locus tag
    RP11-101E13.2
    See related
    Ensembl:ENSG00000116750; HPRD:10293; MIM:610667; Vega:OTTHUMG00000035561
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UCH37; CGI-70; INO80R; UCH-L5

    Genomic context

    Location :
    1q32
    Sequence :
    Chromosome: 1; NC_000001.10 (192981496..193029237, complement)
    See UCHL5 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signaling 2, 24kDa Neighboring gene zinc finger protein 101 pseudogene Neighboring gene TROVE domain family, member 2 Neighboring gene glutaredoxin 2 Neighboring gene cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) Neighboring gene microRNA 1278

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_057068.1 NP_002803.1 PSMD8    BIND  PubMed UCH37 interacts with S14. 
    NP_057068.1 AAF75785.1 TREX2    BIND  PubMed UCH37 interacts with UIP1. 
    Q9Y5K5 Q16186 ADRM1    HPRD  PubMed  
    Q9Y5K5 Q99871 HAUS7    HPRD  PubMed  
    Q9Y5K5 P48556 PSMD8    HPRD  PubMed  
    BioGRID:119509 BioGRID:106575 ACTB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:106585 ACTC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:106586 ACTG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:106596 ACTN4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:122993 ACTR5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:125062 ACTR8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:116235 ADRM1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid 
    BioGRID:119509 BioGRID:115795 ANP32B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:123548 ANP32E    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:106798 ANXA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:106804 ANXA4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:106807 ANXA7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:575558 ANXA8    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:106745 ANXA8L2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:106832 APOA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:106835 APOB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:106878 ARG1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:119509 BioGRID:127385 ASPRV1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:107252 CALM1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:115750 CAP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:107279 CAPZA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:117116 CASP14    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:107472 CDSN    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:107499 CFL1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:107857 CSTA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:107889 CTSD    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:119509 BioGRID:107908 CYB5A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:123309 CYB5B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:108157 DSC1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:108159 DSC3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:108166 DSP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:116255 DUSP14    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:108221 ECHS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:108257 EEF1G    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:108258 EEF2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:108289 EIF4A1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:123666 EPPK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:108601 FLG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:108773 FTH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:108789 FTL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:109202 GSTM3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:120718 HAUS7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:119509 BioGRID:109289 HBA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:109290 HBA2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:109293 HBB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:113955 HIST1H4A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:113962 HIST1H4B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:113960 HIST1H4C    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:113956 HIST1H4D    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:113963 HIST1H4E    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:113957 HIST1H4F    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:113961 HIST1H4H    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:113899 HIST1H4I    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:113959 HIST1H4J    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:113958 HIST1H4K    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:113964 HIST1H4L    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:113966 HIST2H4A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:299853 HIST2H4B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:125732 HIST4H4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:109541 HSPA5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:119509 BioGRID:109547 HSPB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:109642 IDE    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:109721 IGHG1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:120076 INO80    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:120238 INO80D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:129701 INO80E    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:109917 IVL    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:110046 KRT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:110056 KRT10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:110057 KRT12    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:110078 KRT19    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:131677 KRT26    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:127825 KRT28    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:110052 KRT6B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:130489 KRT73    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:128199 KRT78    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:126858 KRT80    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:110055 KRT9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:110186 LMNA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:115710 MCRS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:110748 NACA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:110864 NFRKB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:110906 NOS2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119509 BioGRID:123191 PAAF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111237 PFN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111332 PKM2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:111334 PKP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:111337 PLA2G2A    BioGRID  PubMed Biochemical Activity 
    BioGRID:119509 BioGRID:110921 PNP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:123048 POF1B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:138656 POTEE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:608805 POTEF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:136994 POTEKP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111089 PRDX1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:119509 BioGRID:112860 PRDX2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:116136 PRDX3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:114956 PRDX6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:111664 PSMB3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111666 PSMB5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111667 PSMB6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111673 PSMC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111674 PSMC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111675 PSMC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111677 PSMC4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111678 PSMC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111679 PSMC6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111680 PSMD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111688 PSMD10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111689 PSMD11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111690 PSMD12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111691 PSMD13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:115508 PSMD14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111681 PSMD2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:119509 BioGRID:111682 PSMD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111683 PSMD4    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:119509 BioGRID:115195 PSMD6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111685 PSMD7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:111686 PSMD8    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:119509 BioGRID:111737 PTPN2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:113624 RAB7A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:111824 RAD23B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:121504 S100A14    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:126627 S100A16    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:112186 S100A7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:124597 SERPINB12    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:112223 SERPINB3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:111286 SERPINB5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:112316 SET    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:110262 SMAD2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:110263 SMAD3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:110267 SMAD7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:119509 BioGRID:126716 SRXN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:118931 TFPT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:112911 TGM3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:113020 TPI1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:113128 TUBA4A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:113146 TXN    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:117356 TXN2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:114755 TXNL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:119509 BioGRID:128522 USP12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:114551 USP14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119509 BioGRID:113366 YWHAZ    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119509 BioGRID:113360 YY1    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    • Homologs of the UCHL5 gene: The UCHL5 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    endopeptidase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    omega peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    proteasome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin thiolesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    forebrain morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    lateral ventricle development IEA
    Inferred from Electronic Annotation
    more info
     
    midbrain development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Ino80 complex IDA
    Inferred from Direct Assay
    more info
     
    colocalizes_with Ino80 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase isozyme L5
    Names
    ubiquitin carboxyl-terminal hydrolase isozyme L5
    INO80 complex subunit R
    ubiquitin thioesterase L5
    ubiquitin C-terminal hydrolase UCH37
    ubiquitin carboxyl-terminal esterase L5
    NP_001186190.1
    NP_001186191.1
    NP_001186192.1
    NP_057068.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199261.1NP_001186190.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks one internal residue, compared to isoform 1.
      Source sequence(s)
      AL136370, BC015521, DA255130
      Consensus CDS
      CCDS55668.1
      UniProtKB/Swiss-Prot
      Q9Y5K5
      Related
      ENSP00000356424, OTTHUMP00000033566, ENST00000367454, OTTHUMT00000086319
      Conserved Domains (1) summary
      cd02255
      Location:8223
      Blast Score: 1048
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    2. NM_001199262.1NP_001186191.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region and uses a distinct splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (3) lacks one internal residue and has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC025369, DA255130
      Consensus CDS
      CCDS55670.1
      UniProtKB/Swiss-Prot
      Q9Y5K5
      Related
      ENSP00000356418, OTTHUMP00000033568, ENST00000367448, OTTHUMT00000086321
      Conserved Domains (1) summary
      cd02255
      Location:8223
      Blast Score: 1046
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    3. NM_001199263.1NP_001186192.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the central coding region and uses a distinct splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (4) lacks one internal residue and has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AF151828, BC025369, DA255130
      Consensus CDS
      CCDS55669.1
      UniProtKB/Swiss-Prot
      Q9Y5K5
      Related
      ENSP00000356419, OTTHUMP00000033567, ENST00000367449, OTTHUMT00000086320
      Conserved Domains (1) summary
      cd02255
      Location:8223
      Blast Score: 1047
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    4. NM_015984.3NP_057068.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF147717, AL136370, DA255130
      Consensus CDS
      CCDS1378.1
      UniProtKB/Swiss-Prot
      Q9Y5K5
      Related
      ENSP00000356425, OTTHUMP00000033565, ENST00000367455, OTTHUMT00000086318
      Conserved Domains (1) summary
      cd02255
      Location:8223
      Blast Score: 1046
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

    RNA

    1. NR_037607.1 RNA Sequence

      Description
      Transcript Variant: This variant (5) uses an alternate 5' exon and differs at an internal splice site and at the 3' end, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK301381, BI548319

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      192981496..193029237, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      164217286..164265038, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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