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    PDE1A phosphodiesterase 1A, calmodulin-dependent [ Homo sapiens ]

    Gene ID: 5136, updated on 4-Feb-2012
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    Summary

    Official Symbol
    PDE1Aprovided by HGNC
    Official Full Name
    phosphodiesterase 1A, calmodulin-dependentprovided by HGNC
    Primary source
    HGNC:8774
    See related
    Ensembl:ENSG00000115252; HPRD:01387; MIM:171890; Vega:OTTHUMG00000132596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCAM1; HSPDE1A
    Summary
    Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]
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    Genomic context

    Location :
    2q32.1
    Sequence :
    Chromosome: 2; NC_000002.11 (183007183..183387465, complement)
    See PDE1A in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene keratin 18 pseudogene 29 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 1C Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 10 Neighboring gene ribosomal protein L31 pseudogene 15

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis. Abusnina A, et al. Cell Signal, 2011 Jan. PMID 20807569.
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086.
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    4. Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients. Perlis RH, et al. Biol Psychiatry, 2010 Jun 1. PMID 20110084.
    5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.

    See all (24) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. PDE1A is suggested to be involved in epigenetic mechanisms by targeting the epigenetic integrator UHRF1.
      Title: Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Association of PDE11A global haplotype with major depression and antidepressant drug response.
    5. PDE1A is unlikely to play an important role in antidepressant outcome in this sample
      Title: Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sample.
    6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    7. Variants in PDE1A are not associated with citalopram response in patient with depression.
      Title: Variants in PDE11A and PDE1A are not associated with citalopram response.
    8. PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis.
      Title: Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival.
    9. PDE1A is permanently activated in human spermatozoa
      Title: Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable complex with calmodulin, and PDE3A in human spermatozoa.
    10. Ca2+-calmodulin-dependent phosphodiesterase 1A is activated by sustained entry of Ca2+
      Title: Sustained entry of Ca2+ is required to activate Ca2+-calmodulin-dependent phosphodiesterase 1A.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P54750 P02647 APOA1    HPRD  PubMed  
    P54750 Calmodulin 1 CALM1    HPRD  PubMed  
    BioGRID:111162 BioGRID:106832 APOA1    BioGRID  PubMed Two-hybrid 
    BioGRID:111162 BioGRID:107252 CALM1    BioGRID  PubMed Co-fractionation 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Ca-dependent events, organism-specific biosystem (from REACTOME)
      Ca-dependent events, organism-specific biosystemCalcium, as the ion Ca2+, is essential in many biological processes. The majority of Ca2+ in many organisms is bound to phosphates which form skeletal structures and also buffer Ca2+ levels in extrac...
    • CaM pathway, organism-specific biosystem (from REACTOME)
      CaM pathway, organism-specific biosystemCalmodulin (CaM) is a small acidic protein that contains four EF-hand motifs, each of which can bind a calcium ion, therefore it can bind up to four calcium ions. The protein has two approximately sy...
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calmodulin induced events, organism-specific biosystem (from REACTOME)
      Calmodulin induced events, organism-specific biosystemOne important physiological role for Calmodulin is the regulation of adenylylcyclases. Four of the nine known adenylylcyclases are calcium sensitive, in particular type 8 (AC8).
    • Cam-PDE 1 activation, organism-specific biosystem (from REACTOME)
      Cam-PDE 1 activation, organism-specific biosystemHuman Ca2+/calmodulin-dependent phosphodiesterase PDE1 is activated by the binding of calmodulin in the presence of Ca(2+). PDE1 has three subtypes PDE1A, PDE1B and PDE1C and their role is to hydro...
    • DAG and IP3 signaling, organism-specific biosystem (from REACTOME)
      DAG and IP3 signaling, organism-specific biosystemThis pathway describes the generation of DAG and IP3 by the PLCgamma-mediated hydrolysis of PIP2 and the subsequent downstream signaling events.
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Downstream signal transduction, organism-specific biosystem (from REACTOME)
      Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
    • Downstream signaling of activated FGFR, organism-specific biosystem (from REACTOME)
      Downstream signaling of activated FGFR, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
    • EGFR interacts with phospholipase C-gamma, organism-specific biosystem (from REACTOME)
      EGFR interacts with phospholipase C-gamma, organism-specific biosystemActivated epidermal growth factor receptors (EGFR) can stimulate phosphatidylinositol (PI) turnover. Activated EGFR can activate phospholipase C-gamma1 (PLC-gamma1, i.e. PLCG1) which hydrolyses phosp...
    • G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
      G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
    • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
    • G-protein mediated events, organism-specific biosystem (from REACTOME)
      G-protein mediated events, organism-specific biosystemWhen dissociated Galpha-GTP and Gbeta-gamma can activate or inhibit different signalling cascades and effector proteins. The precise pathways depends on the identity of the alpha and beta/gamma subty...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • Nitric oxide stimulates guanylate cyclase, organism-specific biosystem (from REACTOME)
      Nitric oxide stimulates guanylate cyclase, organism-specific biosystemNitric Oxide (NO) inhibits smooth muscle cell proliferation and migration, oxidation of low-density lipoproteins, and platelet aggregation and adhesion. It can stimulate vasodilatation of the endothe...
    • Opioid Signalling, organism-specific biosystem (from REACTOME)
      Opioid Signalling, organism-specific biosystemOpioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as...
    • PLC beta mediated events, organism-specific biosystem (from REACTOME)
      PLC beta mediated events, organism-specific biosystemThe phospholipase C (PLC) family of enzymes is both diverse and complex. The isoforms beta, gamma and delta (each have subtypes) make up the members of this family. PLC hydrolyzes phosphatidylinosito...
    • PLC-gamma1 signalling, organism-specific biosystem (from REACTOME)
      PLC-gamma1 signalling, organism-specific biosystemThe activation of phosphlipase C-gamma (PLC-gamma) and subsequent mobilization of calcium from intracellular stores are essential for neurotrophin secretion. PLC-gamma is activated through the phosph...
    • PLCG1 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
      PLCG1 events in ERBB2 signaling, organism-specific biosystemActivation of PLCG1 signaling is observed only in the presence of ERBB2:EGFR heterodimers, with PLCG1 binding to phosphorylated tyrosine Y992 and Y1173 in the C-tail of EGFR (Chattopadhyay et al. 199...
    • Phospholipase C-mediated cascade, organism-specific biosystem (from REACTOME)
      Phospholipase C-mediated cascade, organism-specific biosystemPhospholipase C-gamma (PLC-gamma) is a substrate of the fibroblast growth factor receptor (FGFR) and other receptors with tyrosine kinase activity. It is known that the src homology region 2 (SH2 dom...
    • Platelet homeostasis, organism-specific biosystem (from REACTOME)
      Platelet homeostasis, organism-specific biosystemUnder normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in charact...
    • Purine metabolism, organism-specific biosystem (from KEGG)
      Purine metabolism, organism-specific biosystem
      Purine metabolism
    • Purine metabolism, conserved biosystem (from KEGG)
      Purine metabolism, conserved biosystem
      Purine metabolism
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in paralell with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...
    • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
      Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Taste transduction, organism-specific biosystem (from KEGG)
      Taste transduction, organism-specific biosystemAll taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2+ followed by neurotransmitter release. Na+ salt depolarizes taste cells by passive influx of Na...
    • Taste transduction, conserved biosystem (from KEGG)
      Taste transduction, conserved biosystemAll taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2+ followed by neurotransmitter release. Na+ salt depolarizes taste cells by passive influx of N...
    • cGMP effects, organism-specific biosystem (from REACTOME)
      cGMP effects, organism-specific biosystemCyclic guanosine monophosphate (cGMP) is an important secondary messenger synthesized by guanylate cyclases. cGMP has effects on phosphodiesterases (PDE), ion-gated channels, and the cGMP-dependent p...

    Clone Names

    • MGC26303

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    calmodulin-dependent cyclic-nucleotide phosphodiesterase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    activation of phospholipase C activity TAS
    Traceable Author Statement
    more info
    		  
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    nerve growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    signal transduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
    Names
    calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
    hCam-1
    cam-PDE 1A
    61 kDa Cam-PDE
    phosphodiesterase-1A
    calmodulin-dependent phosphodiesterase
    3',5' cyclic nucleotide phosphodiesterase
    calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase
    NP_001003683.1
    NP_005010.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003683.1 → NP_001003683.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA846454, U40370
      Consensus CDS
      CCDS33344.1
      UniProtKB/Swiss-Prot
      P54750
      Related
      ENSP00000387037, OTTHUMP00000205290, ENST00000410103, OTTHUMT00000334356
      Conserved Domains (3) summary
      cd00077
      Location:218 – 389
      Blast Score: 128
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
      pfam00233
      Location:218 – 445
      Blast Score: 925
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:73 – 133
      Blast Score: 185
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    2. NM_005019.3 → NP_005010.2  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1

      Status: VALIDATED

      Source sequence(s)
      BC022480, BG196993, BM719913
      Consensus CDS
      CCDS2285.1
      UniProtKB/Swiss-Prot
      P54750
      Related
      ENSP00000410309, OTTHUMP00000163419, ENST00000435564, OTTHUMT00000255807
      Conserved Domains (3) summary
      cd00077
      Location:218 – 389
      Blast Score: 125
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
      pfam00233
      Location:218 – 445
      Blast Score: 922
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:73 – 133
      Blast Score: 183
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      183007183..183387465, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      174863202..175243415, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB038224.2 BAB20049.1
      BAB20050.1
      BAB20051.1
      BAB20052.1
      BAB20053.1
      BAB20054.1
      BAB20055.1
      BAB20056.1
      BAB20057.1
    genomic AB038224.2 BAB20049.1
      BAB20050.1
      BAB20051.1
      BAB20052.1
      BAB20053.1
      BAB20054.1
      BAB20055.1
      BAB20056.1
      BAB20057.1
    genomic AC010888.12 AAY14837.1
    genomic AC011291.8 (27086..148213) None
    genomic AC012500.7 AAY14812.1
    genomic AF110239.1 AAD40741.1
    genomic CH471058.2 EAX10965.1
      EAX10966.1
      EAX10967.1
      EAX10968.1
      EAX10969.1
      EAX10970.1
      EAX10971.1
      EAX10972.1
      EAX10973.1
      EAX10974.1
      EAX10975.1
    mRNA AA846454.1 None
    mRNA AB038227.1 BAB20037.1
    mRNA AB038228.1 BAB20038.1
    mRNA AF110235.1 AAD40737.1
    mRNA AF110236.1 AAD40738.1
    mRNA AF110237.1 AAD40739.1
    mRNA AF110238.1 AAD40740.1
    mRNA AJ401610.1 CAC82208.1
    mRNA AK130643.1 None
    mRNA AK294239.1 BAH11712.1
    mRNA AK295657.1 BAH12143.1
    mRNA AK301720.1 BAH13538.1
    mRNA AL110263.1 CAB53703.1
    mRNA BC022480.1 AAH22480.1
    mRNA BC047057.1 None
    mRNA BG196993.1 None
    mRNA BM719913.1 None
    mRNA U40370.1 AAC50436.1
    other-genetic DQ892369.2 ABM83295.1
    other-genetic DQ893372.2 ABM84298.1
    other-genetic DQ895578.2 ABM86504.1
    other-genetic DQ896694.2 ABM87693.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P54750.2 GenPept UniProtKB/Swiss-Prot:P54750
    Q53T15 GenPept UniProtKB/TrEMBL:Q53T15
    Q53TB0 GenPept UniProtKB/TrEMBL:Q53TB0
    Q9H3Q8 GenPept UniProtKB/TrEMBL:Q9H3Q8
    Q9H3Q9 GenPept UniProtKB/TrEMBL:Q9H3Q9
    Q9UNL9 GenPept UniProtKB/TrEMBL:Q9UNL9
    Q9Y246 GenPept UniProtKB/TrEMBL:Q9Y246
    Q9Y633 GenPept UniProtKB/TrEMBL:Q9Y633
    Q9Y634 GenPept UniProtKB/TrEMBL:Q9Y634
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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