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    TAOK3 TAO kinase 3 [ Homo sapiens ]

    Gene ID: 51347, updated on 11-May-2012
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    Summary

    Official Symbol
    TAOK3provided by HGNC
    Official Full Name
    TAO kinase 3provided by HGNC
    Primary source
    HGNC:18133
    See related
    Ensembl:ENSG00000135090; HPRD:11620; Vega:OTTHUMG00000168875
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DPK; JIK; MAP3K18; FLJ31808; DKFZp666H245
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    Genomic context

    Location :
    12q
    Sequence :
    Chromosome: 12; NC_000012.11 (118587606..118810750, complement)
    See TAOK3 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene V-set and immunoglobulin domain containing 10 Neighboring gene phosphatidylethanolamine binding protein 1 Neighboring gene ribosomal protein S2 pseudogene 5 Neighboring gene suppressor of defective silencing 3 homolog (S. cerevisiae) Neighboring gene ribosomal protein L17 pseudogene 37

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    2. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
    3. A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. Mu JJ, et al. J Biol Chem, 2007 Jun 15. PMID 17478428.
    4. TAO kinases mediate activation of p38 in response to DNA damage. Raman M, et al. EMBO J, 2007 Apr 18. PMID 17396146.
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9H2K8 O75460 ERN1    HPRD  PubMed  
    Q9H2K8 Q9H2K8 TAOK3    HPRD  PubMed  
    Q9H2K8 Q12933 TRAF2    HPRD  PubMed  
    BioGRID:119490 BioGRID:106962 ATM    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119490 BioGRID:108391 ERN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119490 BioGRID:113038 TRAF2    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • p38 MAPK signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      p38 MAPK signaling pathway, organism-specific biosystem
      p38 MAPK signaling pathway

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    G2/M transition DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of stress-activated MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    serine/threonine-protein kinase TAO3
    Names
    serine/threonine-protein kinase TAO3
    hKFC-A
    STE20-like kinase
    JNK/SAPK-inhibitory kinase
    jun kinase-inhibitory kinase
    kinase from chicken homolog A
    CTCL-associated antigen HD-CL-09
    dendritic cell-derived protein kinase
    thousand and one amino acid protein 3
    cutaneous T-cell lymphoma-associated antigen HD-CL-09
    NP_057365.3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016281.3 → NP_057365.3  serine/threonine-protein kinase TAO3

      Status: VALIDATED

      Source sequence(s)
      AA744362, AI057643, AL833460, BC002756, DB066061
      Consensus CDS
      CCDS9188.1
      UniProtKB/Swiss-Prot
      Q9H2K8
      Related
      ENSP00000376317, OTTHUMP00000239670, ENST00000392533, OTTHUMT00000401456
      Conserved Domains (3) summary
      cd06607
      Location:8 – 314
      Blast Score: 1643
      STKc_TAO; Catalytic domain of the Protein Serine/Threonine Kinase, Thousand-and-one amino acids proteins
      smart00220
      Location:27 – 277
      Blast Score: 654
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam09731
      Location:747 – 864
      Blast Score: 102
      Mitofilin; Mitochondrial inner membrane protein

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      118587606..118810750, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      115597575..115819970, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC026366.20 (49279..164428) None
    genomic AC026367.14 (45452..107028) None
    genomic AC073596.40 None
    genomic CH471054.1 EAW98124.1
      EAW98125.1
    genomic HH961884.1 CBX51415.1
    mRNA AA744362.1 None
    mRNA AF135158.1 AAG09131.1
    mRNA AF161373.1 AAF28933.1
    mRNA AF179867.1 AAF14559.1
    mRNA AF181985.1 AAF25817.1
    mRNA AF263311.1 AAG38501.1
    mRNA AF328731.1 AAN09723.1
    mRNA AI057643.1 None
    mRNA AK056370.1 BAG51691.1
    mRNA AK289558.1 BAF82247.1
    mRNA AL833460.1 None
    mRNA AL833731.1 CAH56239.1
    mRNA BC002756.2 AAH02756.1
    mRNA BT007185.1 AAP35849.1
    mRNA DB066061.1 None
    other-genetic DQ890696.2 ABM81622.1
    other-genetic DQ893881.2 ABM84807.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H2K8.2 GenPept UniProtKB/Swiss-Prot:Q9H2K8
    Q9P0C6 GenPept UniProtKB/TrEMBL:Q9P0C6
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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