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    TAOK3 TAO kinase 3 [ Homo sapiens (human) ]

    Gene ID: 51347, updated on 9-Jun-2013
    Official Symbol
    TAOK3provided by HGNC
    Official Full Name
    TAO kinase 3provided by HGNC
    Primary source
    HGNC:18133
    See related
    Ensembl:ENSG00000135090; HPRD:11620; Vega:OTTHUMG00000168875
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DPK; JIK; MAP3K18
    Location :
    12q
    Sequence :
    Chromosome: 12; NC_000012.11 (118587606..118810750, complement)
    See TAOK3 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene V-set and immunoglobulin domain containing 10 Neighboring gene phosphatidylethanolamine binding protein 1 Neighboring gene ribosomal protein S2 pseudogene 5 Neighboring gene suppressor of defective silencing 3 homolog (S. cerevisiae) Neighboring gene ribosomal protein L17 pseudogene 37

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Taipale M, et al. Cell, 2012 Aug 31. PMID 22939624.
    2. Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity. Zach S, et al. PLoS One, 2010 Oct 7. PMID 20949042.
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    4. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
    5. A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. Mu JJ, et al. J Biol Chem, 2007 Jun 15. PMID 17478428.

    See all (15) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    Q9H2K8 O75460 ERN1    HPRD  PubMed  
    Q9H2K8 Q9H2K8 TAOK3    HPRD  PubMed  
    Q9H2K8 Q12933 TRAF2    HPRD  PubMed  
    BioGRID:119490 BioGRID:106962 ATM    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119490 BioGRID:108391 ERN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119490 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:119490 BioGRID:125700 LRRK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:119490 BioGRID:113038 TRAF2    BioGRID  PubMed Affinity Capture-Western 
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • p38 MAPK signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      p38 MAPK signaling pathway, organism-specific biosystem
      p38 MAPK signaling pathway

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ31808, DKFZp666H245

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    G2 DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of stress-activated MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    serine/threonine-protein kinase TAO3
    Names
    serine/threonine-protein kinase TAO3
    hKFC-A
    STE20-like kinase
    JNK/SAPK-inhibitory kinase
    jun kinase-inhibitory kinase
    kinase from chicken homolog A
    CTCL-associated antigen HD-CL-09
    dendritic cell-derived protein kinase
    thousand and one amino acid protein 3
    cutaneous T-cell lymphoma-associated antigen HD-CL-09
    NP_057365.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016281.3 → NP_057365.3  serine/threonine-protein kinase TAO3

      Status: VALIDATED

      Source sequence(s)
      AA744362, AI057643, AL833460, BC002756, DB066061
      Consensus CDS
      CCDS9188.1
      UniProtKB/Swiss-Prot
      Q9H2K8
      Related
      ENSP00000376317, OTTHUMP00000239670, ENST00000392533, OTTHUMT00000401456
      Conserved Domains (2) summary
      cd06607
      Location:8 – 314
      Blast Score: 1643
      STKc_TAO; Catalytic domain of the Protein Serine/Threonine Kinase, Thousand-and-one amino acids proteins
      smart00220
      Location:27 – 277
      Blast Score: 654
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p10 Primary Assembly

      Range
      118587606..118810750, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      115597575..115819970, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018923.1 Alternate CHM1_1.0

      Range
      118380594..118603700, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01020051.1 (26335..40677) None
    genomic ABBA01020052.1 None
    genomic ABBA01020053.1 None
    genomic ABBA01020054.1 None
    genomic ABBA01020055.1 None
    genomic ABBA01020056.1 None
    genomic ABBA01020057.1 None
    genomic ABBA01020058.1 None
    genomic ABBA01020059.1 None
    genomic AC026366.20 (49280..164429) None
    genomic AC026367.14 (45453..107029) None
    genomic AC073596.40 None
    genomic AMYH01004786.1 (193118..416224) None
    genomic CH471054.1 EAW98124.1
      EAW98125.1
    genomic HH961884.1 CBX51415.1
    mRNA AA744362.1 None
    mRNA AF135158.1 AAG09131.1
    mRNA AF161373.1 AAF28933.1
    mRNA AF179867.1 AAF14559.1
    mRNA AF181985.1 AAF25817.1
    mRNA AF263311.1 AAG38501.1
    mRNA AF328731.1 AAN09723.1
    mRNA AI057643.1 None
    mRNA AK056370.1 BAG51691.1
    mRNA AK289558.1 BAF82247.1
    mRNA AL833460.1 None
    mRNA AL833731.1 CAH56239.1
    mRNA BC002756.2 AAH02756.1
    mRNA BT007185.1 AAP35849.1
    mRNA DB066061.1 None
    other-genetic DQ890696.2 ABM81622.1
    other-genetic DQ893881.2 ABM84807.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H2K8.2 GenPept UniProtKB/Swiss-Prot:Q9H2K8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioAssay, by Protein Target
        BioAssay, by Protein Target
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

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