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SPTBN5 spectrin, beta, non-erythrocytic 5 [ Homo sapiens (human) ]

Gene ID: 51332, updated on 22-Nov-2014
Official Symbol
SPTBN5provided by HGNC
Official Full Name
spectrin, beta, non-erythrocytic 5provided by HGNC
Primary source
HGNC:HGNC:15680
See related
Ensembl:ENSG00000137877; HPRD:10438; MIM:605916; Vega:OTTHUMG00000172720
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BSPECV; HUSPECV; HUBSPECV
See SPTBN5 in Epigenomics, MapViewer
Location:
15q21
Exon count:
68
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 15 NC_000015.10 (41848146..41894077, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42140344..42186275, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase binding protein 1 Neighboring gene JMJD7-PLA2G4B readthrough Neighboring gene jumonji domain containing 7 Neighboring gene phospholipase A2, group IVB (cytosolic) Neighboring gene RNA, 5S ribosomal pseudogene 393 Neighboring gene microRNA 4310 Neighboring gene EH-domain containing 4 Neighboring gene EHD4 antisense RNA 1 Neighboring gene PLA2G4E antisense RNA 1 Neighboring gene phospholipase A2, group IVE

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin PubMed

Go to the HIV-1, Human Interaction Database

  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Interaction between L1 and Ankyrins, organism-specific biosystem (from REACTOME)
    Interaction between L1 and Ankyrins, organism-specific biosystemAnkyrins are a family of adaptor proteins that couple membrane proteins such as voltage gated Na+ channels and the Na+/K+ anion exchanger to the spectrin actin cytoskeleton. Ankyrins are encoded by t...
  • L1CAM interactions, organism-specific biosystem (from REACTOME)
    L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
  • NCAM signaling for neurite out-growth, organism-specific biosystem (from REACTOME)
    NCAM signaling for neurite out-growth, organism-specific biosystemThe neural cell adhesion molecule, NCAM, is a member of the immunoglobulin (Ig) superfamily and is involved in a variety of cellular processes of importance for the formation and maintenance of the n...

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding NAS
Non-traceable Author Statement
more info
PubMed 
dynactin binding IDA
Inferred from Direct Assay
more info
PubMed 
dynein intermediate chain binding IDA
Inferred from Direct Assay
more info
PubMed 
kinesin binding IDA
Inferred from Direct Assay
more info
PubMed 
myosin tail binding IDA
Inferred from Direct Assay
more info
PubMed 
protein self-association IDA
Inferred from Direct Assay
more info
PubMed 
spectrin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin cytoskeleton organization NAS
Non-traceable Author Statement
more info
PubMed 
actin filament capping IEA
Inferred from Electronic Annotation
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
lysosomal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane NAS
Non-traceable Author Statement
more info
PubMed 
photoreceptor connecting cilium IDA
Inferred from Direct Assay
more info
PubMed 
photoreceptor disc membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein complex IEA
Inferred from Electronic Annotation
more info
 
spectrin NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
spectrin beta chain, non-erythrocytic 5
Names
spectrin beta chain, non-erythrocytic 5
beta V spectrin
beta-V spectrin
spectrin beta chain, brain 4
spectrin, non-erythroid beta chain 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016642.3NP_057726.4  spectrin beta chain, non-erythrocytic 5

    See proteins identical to NP_057726.4

    Status: VALIDATED

    Source sequence(s)
    AA599654, AC020659, AF233523
    Consensus CDS
    CCDS61599.1
    UniProtKB/Swiss-Prot
    Q9NRC6
    Related
    ENSP00000317790, OTTHUMP00000249226, ENST00000320955, OTTHUMT00000420237
    Conserved Domains (4) summary
    smart00150
    Location:34233482
    SPEC; Spectrin repeats
    cd00014
    Location:178280
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:15211727
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd10571
    Location:35363639
    PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Alternate HuRef

Genomic

  1. AC_000147.1 

    Range
    18988732..19034698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000015.10 

    Range
    41848146..41894077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254438.2XP_005254495.1  

    Conserved Domains (4) summary
    smart00150
    Location:34433502
    SPEC; Spectrin repeats
    cd00014
    Location:198300
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:15411747
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd10571
    Location:35563659
    PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 

    Range
    42258817..42304755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)