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MRPL35 mitochondrial ribosomal protein L35 [ Homo sapiens (human) ]

Gene ID: 51318, updated on 8-May-2016
Official Symbol
MRPL35provided by HGNC
Official Full Name
mitochondrial ribosomal protein L35provided by HGNC
Primary source
HGNC:HGNC:14489
See related
Ensembl:ENSG00000132313 HPRD:14755; MIM:611841; Vega:OTTHUMG00000037385
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L35mt; MRP-L35
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p, 10q, and Xp. [provided by RefSeq, Jul 2008]
Orthologs
Location:
2p11.2
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (86199355..86213794)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (86426478..86440913)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene pentatricopeptide repeat domain 3 Neighboring gene small nucleolar RNA, C/D box 94 Neighboring gene inner membrane mitochondrial protein Neighboring gene microRNA 4779 Neighboring gene receptor accessory protein 1 Neighboring gene uncharacterized LOC105374844 Neighboring gene lysine demethylase 3A

  • Mitochondrial translation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation, organism-specific biosystemOf the roughly 1000 human mitochondrial proteins only 13 proteins, all of them hydrophobic inner membrane proteins that are components of the oxidative phosphorylation apparatus, are encoded in the m...
  • Mitochondrial translation elongation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation elongation, organism-specific biosystemTranslation elongation proceeds by cycles of aminoacyl-tRNAs binding, peptide bond formation, and displacement of deacylated tRNAs (reviewed in Christian and Spremulli 2012). In each cycle an aminoac...
  • Mitochondrial translation initiation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation initiation, organism-specific biosystemTranslation initiates with the mitochondrial mRNA binding the 28S subunit:MTIF3 (28S subunit:IF-3Mt, 28S subunit:IF3mt) complex together with MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP) (reviewed in Christian ...
  • Mitochondrial translation termination, organism-specific biosystem (from REACTOME)
    Mitochondrial translation termination, organism-specific biosystemTranslation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • Ribosome, organism-specific biosystem (from KEGG)
    Ribosome, organism-specific biosystem
    Ribosome
  • Ribosome, conserved biosystem (from KEGG)
    Ribosome, conserved biosystem
    Ribosome
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial ribosome NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
39S ribosomal protein L35, mitochondrial

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016622.3NP_057706.2  39S ribosomal protein L35, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_057706.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), with the upstream polyadenylation site, is the predominant transcript and encodes isoform a.
    Source sequence(s)
    AL832982, BG108475, BQ421154, BQ879834, BU195549, DA413384, DA443416, DB245340, F11007, H11039
    Consensus CDS
    CCDS1988.1
    UniProtKB/Swiss-Prot
    Q9NZE8
    Related
    ENSP00000338389, OTTHUMP00000035512, ENST00000337109, OTTHUMT00000091002
    Conserved Domains (1) summary
    pfam01632
    Location:102162
    Ribosomal_L35p; Ribosomal protein L35
  2. NM_145644.2NP_663619.1  39S ribosomal protein L35, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_663619.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment, compared to variant 1, that causes a frameshift and a shorter 3' UTR. The resulting isoform (b) has a shorter C-terminus when compared to isoform a.
    Source sequence(s)
    AK314577, AL832982, BC020651, BU195549, DA413384, F11007, H11039
    Consensus CDS
    CCDS1987.1
    UniProtKB/Swiss-Prot
    Q9NZE8
    Related
    ENSP00000254644, OTTHUMP00000035511, ENST00000254644, OTTHUMT00000091001
    Conserved Domains (1) summary
    pfam01632
    Location:102162
    Ribosomal_L35p; Ribosomal protein L35

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    86199355..86213794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264361.2XP_005264418.1  

    UniProtKB/TrEMBL
    D3YTC1
    Related
    ENSP00000386255, OTTHUMP00000203313, ENST00000409180, OTTHUMT00000330003
    Conserved Domains (1) summary
    pfam01632
    Location:102162
    Ribosomal_L35p; Ribosomal protein L35

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    86356001..86369922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)