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    CDK18 cyclin-dependent kinase 18 [ Homo sapiens ]

    Gene ID: 5129, updated on 11-May-2012
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    Summary

    Official Symbol
    CDK18provided by HGNC
    Official Full Name
    cyclin-dependent kinase 18provided by HGNC
    Primary source
    HGNC:8751
    Locus tag
    RP11-288G13.1
    See related
    Ensembl:ENSG00000117266; HPRD:01354; MIM:169190; Vega:OTTHUMG00000037203
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCTK3; PCTAIRE; PCTAIRE3
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    Genomic context

    Location :
    1q31-q32
    Sequence :
    Chromosome: 1; NC_000001.10 (205473684..205501921)
    See CDK18 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene microRNA 135b Neighboring gene uncharacterized LOC284577 Neighboring gene uncharacterized LOC284578 Neighboring gene major facilitator superfamily domain containing 4

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. Cyclin-dependent kinases: a family portrait. Malumbres M, et al. Nat Cell Biol, 2009 Nov. PMID 19884882.
    5. Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. Wissing J, et al. Mol Cell Proteomics, 2007 Mar. PMID 17192257.

    See all (20) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. PCTAIRE 3 is aassociated kinase that modulates tau phosphorylation in Alzeheimer's disease.
      Title: The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease.
    2. Expression of PCTAIRE 3a (474 amino acids) was evident throughout the brain and in the majority of tissues analyzed, while spliced isoform PCTAIRE 3b (504 amino acids) was limited to several subcortical nuclei of the basal gangli and the spinal cord.
      Title: Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q07002 Q15834 CCDC85B    HPRD  PubMed  
    Q07002 O75909 CCNK    HPRD  PubMed  
    Q07002 Q15436 SEC23A    HPRD  PubMed  
    BioGRID:111156 BioGRID:116198 CCDC85B    BioGRID  PubMed Two-hybrid 
    BioGRID:111156 BioGRID:114339 CCNK    BioGRID  PubMed Two-hybrid 
    BioGRID:111156 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111156 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding NAS
    Non-traceable Author Statement
    more info
    		  
    cyclin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    		  
    signal transducer activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		  
    signal transduction NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
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    General protein information

    Preferred Names
    cyclin-dependent kinase 18
    Names
    cyclin-dependent kinase 18
    PCTAIRE protein kinase 3
    PCTAIRE-motif protein kinase 3
    cell division protein kinase 18
    serine/threonine-protein kinase PCTAIRE-3
    NP_002587.2
    NP_997667.1
    NP_997668.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002596.3 → NP_002587.2  cyclin-dependent kinase 18 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode isoform b.
      Source sequence(s)
      AB209307, AL357131, BC011526, BM695474, DC381358
      Consensus CDS
      CCDS44300.1
      UniProtKB/Swiss-Prot
      Q07002
      UniProtKB/TrEMBL
      Q59G02
      Related
      ENSP00000353176, OTTHUMP00000035326, ENST00000360066, OTTHUMT00000090407
      Conserved Domains (2) summary
      cd07871
      Location:138 – 425
      Blast Score: 1509
      STKc_PCTAIRE3; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase
      PLN00009
      Location:141 – 429
      Blast Score: 934
      PLN00009; cyclin-dependent kinase A; Provisional

    2. NM_212502.2 → NP_997667.1  cyclin-dependent kinase 18 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in a coding exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode isoform b.
      Source sequence(s)
      AB209307, AY353237, BM695474, DC381358
      Consensus CDS
      CCDS44300.1
      UniProtKB/Swiss-Prot
      Q07002
      UniProtKB/TrEMBL
      Q59G02
      Related
      ENSP00000399082, OTTHUMP00000035327, ENST00000429964, OTTHUMT00000090409
      Conserved Domains (2) summary
      cd07871
      Location:138 – 425
      Blast Score: 1509
      STKc_PCTAIRE3; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase
      PLN00009
      Location:141 – 429
      Blast Score: 934
      PLN00009; cyclin-dependent kinase A; Provisional

    3. NM_212503.2 → NP_997668.1  cyclin-dependent kinase 18 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AB209307, AY353238, BM695474, DC381358
      Consensus CDS
      CCDS1454.1
      UniProtKB/Swiss-Prot
      Q07002
      UniProtKB/TrEMBL
      Q59G02
      Related
      ENSP00000423665, OTTHUMP00000035328, ENST00000506784, OTTHUMT00000090412
      Conserved Domains (2) summary
      cd07871
      Location:168 – 455
      Blast Score: 1516
      STKc_PCTAIRE3; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase
      PLN00009
      Location:171 – 459
      Blast Score: 937
      PLN00009; cyclin-dependent kinase A; Provisional

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      205473684..205501921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      176639088..176667323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL357131.27 CAH72009.1
      CAH72010.1
      CAH72011.1
      CAH72012.1
    genomic CH471067.1 EAW91559.1
      EAW91560.1
      EAW91561.1
      EAW91562.1
    mRNA AB209307.1 BAD92544.1
    mRNA AK126879.1 BAG54388.1
    mRNA AK293756.1 BAG57176.1
    mRNA AK295272.1 BAG58258.1
    mRNA AK295654.1 BAG58521.1
    mRNA AK296320.1 BAG59015.1
    mRNA AK308913.1 None
    mRNA AL161977.1 None
    mRNA AU130437.1 None
    mRNA AY353237.1 AAR13065.1
    mRNA AY353238.1 AAR13066.1
    mRNA AY353239.1 None
    mRNA AY353240.1 None
    mRNA BC000281.2 AAH00281.2
    mRNA BC009223.2 None
    mRNA BC011526.1 AAH11526.1
    mRNA BC040529.1 AAH40529.1
    mRNA BM695474.1 None
    mRNA BM772779.1 None
    mRNA BT007299.1 AAP35963.1
    mRNA BU165355.1 None
    mRNA DC381358.1 None
    mRNA X66362.1 CAA47005.1
    other-genetic DQ893540.2 ABM84466.1
    other-genetic DQ893749.2 ABM84675.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07002.3 GenPept UniProtKB/Swiss-Prot:Q07002
    Q59G02 GenPept UniProtKB/TrEMBL:Q59G02
    Q5VXQ3 GenPept UniProtKB/TrEMBL:Q5VXQ3
    Q5VXQ4 GenPept UniProtKB/TrEMBL:Q5VXQ4
    Q5VXQ5 GenPept UniProtKB/TrEMBL:Q5VXQ5
    Q8IWB3 GenPept UniProtKB/TrEMBL:Q8IWB3
    Q9BWF9 GenPept UniProtKB/TrEMBL:Q9BWF9
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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