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    KLF3 Kruppel-like factor 3 (basic) [ Homo sapiens (human) ]

    Gene ID: 51274, updated on 5-May-2013
    Official Symbol
    KLF3provided by HGNC
    Official Full Name
    Kruppel-like factor 3 (basic)provided by HGNC
    Primary source
    HGNC:16516
    See related
    Ensembl:ENSG00000109787; HPRD:13920; MIM:609392; Vega:OTTHUMG00000097821
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BKLF
    Location :
    4p14
    Sequence :
    Chromosome: 4; NC_000004.11 (38665790..38703129)
    See KLF3 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 Neighboring gene mitochondrial ribosomal protein S33 pseudogene 2 Neighboring gene proteasome activator subunit 2 pseudogene 4 Neighboring gene uncharacterized FLJ13197 Neighboring gene toll-like receptor 10 Neighboring gene toll-like receptor 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Impaired B cell development in the absence of Krüppel-like factor 3. Vu TT, et al. J Immunol, 2011 Nov 15. PMID 22003205.
    2. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Tatham MH, et al. Sci Signal, 2011 Jun 21. PMID 21693764.
    3. Deregulated expression of Kruppel-like factors in acute myeloid leukemia. Humbert M, et al. Leuk Res, 2011 Jul. PMID 21470678.
    4. The mammalian zinc finger transcription factor Krüppel-like factor 3 (KLF3/BKLF). Pearson RC, et al. IUBMB Life, 2011 Feb. PMID 21360637.
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086.

    See all (21) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. B cell differentiation is significantly impaired in the bone marrow, spleen, and peritoneal cavity of Klf3 null mice; the defects are cell autonomous.
      Title: Impaired B cell development in the absence of Krüppel-like factor 3.
    2. Low KLF3 is associated with acute myeloid leukemia.
      Title: Deregulated expression of Kruppel-like factors in acute myeloid leukemia.
    3. KLF3 is an important regulator of several biological processes, including adipogenesis, erythropoiesis, and B cell development. (Review)
      Title: The mammalian zinc finger transcription factor Krüppel-like factor 3 (KLF3/BKLF).
    4. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    7. The recruitment of CtBP and sumoylation are required for full repression by BKLF.
      Title: Role for SUMO modification in facilitating transcriptional repression by BKLF.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    P57682 P56545 CTBP2    HPRD  PubMed  
    BioGRID:119426 BioGRID:107870 CTBP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:119426 BioGRID:108566 FHL3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:119426 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC48279

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    multicellular organismal development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    Krueppel-like factor 3
    Names
    Krueppel-like factor 3
    TEF-2
    transcript ch138
    basic Kruppel-like factor
    basic kruppel like factor
    basic krueppel-like factor
    CACCC-box-binding protein BKLF

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016531.5 → NP_057615.3  Krueppel-like factor 3

      Status: VALIDATED

      Source sequence(s)
      AC021860, AF285837, BU689914, DB246277
      Consensus CDS
      CCDS3444.1
      UniProtKB/Swiss-Prot
      P57682
      Related
      ENSP00000261438, OTTHUMP00000123486, ENST00000261438, OTTHUMT00000215093
      Conserved Domains (2) summary
      COG5048
      Location:181 – 332
      Blast Score: 87
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam13465
      Location:306 – 331
      Blast Score: 101
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p10 Primary Assembly

      Range
      38665790..38703129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      37989129..38026462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018915.1 Alternate CHM1_1.0

      Range
      38556422..38593813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01074329.1 (138..37471) None
    genomic AC021860.6 (72079..109268) None
    genomic AMYH01014115.1 (148062..148851) None
    genomic AMYH01014116.1 None
    genomic CH471069.1 EAW92895.1
      EAW92896.1
    mRNA AB024523.1 BAA92271.1
    mRNA AF285837.1 AAK27329.1
    mRNA AK313459.1 BAG36246.1
    mRNA BC030662.1 AAH30662.1
    mRNA BC051687.1 AAH51687.1
    mRNA BU689914.1 None
    mRNA DB246277.1 None
    mRNA S77393.1 None
    other-genetic HQ447450.1 ADQ31936.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P57682.1 GenPept UniProtKB/Swiss-Prot:P57682

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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