My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    CDK16 cyclin-dependent kinase 16 [ Homo sapiens ]

    Gene ID: 5127, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    CDK16provided by HGNC
    Official Full Name
    cyclin-dependent kinase 16provided by HGNC
    Primary source
    HGNC:8749
    See related
    Ensembl:ENSG00000102225; HPRD:02409; MIM:311550; Vega:OTTHUMG00000021438
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCTK1; PCTAIRE; PCTAIRE1; PCTGAIRE; FLJ16665
    Summary
    The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]
    Help top of page

    Genomic context

    Location :
    Xp11
    Sequence :
    Chromosome: X; NC_000023.10 (47077528..47089396)
    See CDK16 in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene inositol 1,3,4-triphosphate 5/6 kinase pseudogene Neighboring gene RNA binding motif protein 10 Neighboring gene ubiquitin-like modifier activating enzyme 1 Neighboring gene inactivation escape 1 (non-protein coding) Neighboring gene ubiquitin specific peptidase 11 Neighboring gene nicolin 2, pseudogene

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis. Mikolcevic P, et al. Mol Cell Biol, 2012 Feb. PMID 22184064.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Cyclin-dependent kinase 5-dependent phosphorylation of Pctaire1 regulates dendrite development. Fu WY, et al. Neuroscience, 2011 Apr 28. PMID 21335063.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (32) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. CCNY binding to CDK16 required a region upstream of the kinase domain and was found to be inhibited by phosphorylation of serine 153, a potential PKA phosphorylation site.
      Title: Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis.
    2. Cdk5-dependent phosphorylation of Pctaire1 at Ser95 plays an important role in dendrite development
      Title: Cyclin-dependent kinase 5-dependent phosphorylation of Pctaire1 regulates dendrite development.
    3. Data show that various forms of PCTAIRE-1 transfected into neuroblastoma cell lines could either promote or inhibit neurite outgrowth, suggesting a potential role for the PCTAIRE-1 gene product in the control of neurite outgrowth.
      Title: Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells.
    4. Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein
      Title: Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_148978.1 NP_057864.1 tax    BIND  PubMed Tax interacts with PCTAIRE-1. 
    Q00536 P46379 BAG6    HPRD  PubMed  
    Q00536 Q00536 CDK16    HPRD  PubMed  
    Q00536 Q00535 CDK5    HPRD  PubMed  
    Q00536 Q15078 CDK5R1    HPRD  PubMed  
    Q00536 P17612 PRKACA    HPRD  PubMed  
    Q00536 Q15436 SEC23A    HPRD  PubMed  
    Q00536 P62258 YWHAE    HPRD  PubMed  
    Q00536 P61981 YWHAG    HPRD  PubMed  
    Q00536 Q04917 YWHAH    HPRD  PubMed  
    Q00536 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:111154 BioGRID:107140 BRCA1    BioGRID  PubMed Two-hybrid 
    BioGRID:111154 BioGRID:107455 CDK5    BioGRID  PubMed Biochemical Activity 
    BioGRID:111154 BioGRID:114376 CDK5R1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111154 BioGRID:198624 Cdk1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111154 BioGRID:112189 S100A10    BioGRID  PubMed Two-hybrid 
    BioGRID:111154 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111154 BioGRID:113364 YWHAG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111154 BioGRID:113365 YWHAH    BioGRID  PubMed Two-hybrid 
    BioGRID:111154 BioGRID:116168 YWHAQ    BioGRID  PubMed Two-hybrid 
    BioGRID:111154 BioGRID:113366 YWHAZ    BioGRID  PubMed Two-hybrid 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    cyclin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    cyclin-dependent kinase 16
    Names
    cyclin-dependent kinase 16
    PCTAIRE-motif protein kinase 1
    cell division protein kinase 16
    serine/threonine-protein kinase PCTAIRE-1
    NP_001163931.1
    NP_006192.1
    NP_148978.2
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012517.1 RefSeqGene

      Range
      5001..16869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170460.1 → NP_001163931.1  cyclin-dependent kinase 16 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate exon in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform 3, which has a longer and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK096881, AK290145, AK301832, BC006190
      Consensus CDS
      CCDS55408.1
      UniProtKB/TrEMBL
      B7Z7C8
      UniProtKB/Swiss-Prot
      Q00536
      UniProtKB/TrEMBL
      Q9BRL4
      Related
      ENSP00000276052, ENST00000276052
      Conserved Domains (2) summary
      cd07873
      Location:232 – 532
      Blast Score: 1549
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
      PLN00009
      Location:236 – 524
      Blast Score: 906
      PLN00009; cyclin-dependent kinase A; Provisional

    2. NM_006201.4 → NP_006192.1  cyclin-dependent kinase 16 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shortest isoform (1).
      Source sequence(s)
      AK096881, AK290145, BC006190, DA816614
      Consensus CDS
      CCDS14276.1
      UniProtKB/Swiss-Prot
      Q00536
      UniProtKB/TrEMBL
      Q9BRL4
      Related
      ENSP00000349762, OTTHUMP00000023208, ENST00000357227, OTTHUMT00000056406
      Conserved Domains (2) summary
      cd07873
      Location:158 – 458
      Blast Score: 1537
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
      PLN00009
      Location:162 – 450
      Blast Score: 901
      PLN00009; cyclin-dependent kinase A; Provisional

    3. NM_033018.3 → NP_148978.2  cyclin-dependent kinase 16 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform 2, which has a longer and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      BC015607, BQ187876, DA900611
      Consensus CDS
      CCDS48101.1
      UniProtKB/Swiss-Prot
      Q00536
      Related
      ENSP00000405798, OTTHUMP00000023209, ENST00000457458, OTTHUMT00000056407
      Conserved Domains (2) summary
      cd07873
      Location:164 – 464
      Blast Score: 1538
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
      PLN00009
      Location:168 – 456
      Blast Score: 902
      PLN00009; cyclin-dependent kinase A; Provisional

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p5 Primary Assembly

      Range
      47077528..47089396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      44787880..44799166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL096791.13 CAD20055.1
    genomic AL513366.11 (143276..145455) None
    genomic CH471164.1 EAW59294.1
      EAW59295.1
      EAW59296.1
      EAW59297.1
      EAW59298.1
    mRNA AK096881.1 None
    mRNA AK131486.1 BAD18631.1
    mRNA AK290145.1 BAF82834.1
    mRNA AK296880.1 BAH12447.1
    mRNA AK301832.1 BAH13564.1
    mRNA AK303849.1 BAH14066.1
    mRNA BC001048.2 AAH01048.1
    mRNA BC006190.2 AAH06190.1
    mRNA BC009852.2 AAH09852.2
    mRNA BC015607.2 AAH15607.1
    mRNA BG029956.1 None
    mRNA BQ187876.1 None
    mRNA BT006827.1 AAP35473.1
    mRNA DA816614.1 None
    mRNA DA900611.1 None
    mRNA X66363.1 CAA47006.1
    mRNA AB209465.1 BAD92702.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00536.1 GenPept UniProtKB/Swiss-Prot:Q00536
    Q59FJ5 GenPept UniProtKB/TrEMBL:Q59FJ5
    Q6ZMU4 GenPept UniProtKB/TrEMBL:Q6ZMU4
    Q96GA5 GenPept UniProtKB/TrEMBL:Q96GA5
    Q9BRL4 GenPept UniProtKB/TrEMBL:Q9BRL4
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...