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    CDKL3 cyclin-dependent kinase-like 3 [ Homo sapiens ]

    Gene ID: 51265, updated on 11-May-2012
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    Summary

    Official Symbol
    CDKL3provided by HGNC
    Official Full Name
    cyclin-dependent kinase-like 3provided by HGNC
    Primary source
    HGNC:15483
    See related
    Ensembl:ENSG00000006837; MIM:608459; Vega:OTTHUMG00000164185
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NKIAMRE
    Summary
    The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    5q31
    Sequence :
    Chromosome: 5; NC_000005.9 (133634115..133702765, complement)
    See CDKL3 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2, catalytic subunit, alpha isozyme Neighboring gene microRNA 3661 Neighboring gene ribosomal protein S13 pseudogene 6 Neighboring gene ubiquitin-conjugating enzyme E2B Neighboring gene CDKN2A interacting protein N-terminal like

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    2. Inactivation of the CDKL3 gene at 5q31.1 by a balanced t(X;5) translocation associated with nonspecific mild mental retardation. Dubos A, et al. Am J Med Genet A, 2008 May 15. PMID 18412109.
    3. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
    4. Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog. Jaluria P, et al. BMC Biotechnol, 2007 Oct 18. PMID 17945021.
    5. Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation. Tao J, et al. Am J Hum Genet, 2004 Dec. PMID 15499549.

    See all (9) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. data suggest that the CDKL3 gene is a strong candidate for nonsyndromal autosomal dominant mild mental retardation
      Title: Inactivation of the CDKL3 gene at 5q31.1 by a balanced t(X;5) translocation associated with nonspecific mild mental retardation.
    3. cdkl3 transfected in anchorage-independent (suspension) HeLa cells overexpressed relative to attached cells and lead to elevated proliferation and faster transition G0/G1 phases to S phase relative to controls. Same in two HEK-293 and a CHO cell lines.
      Title: Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog.
    4. NKIAMRE is a member of a conserved family of kinases with homology to both MAP kinases and cyclin-dependent kinases
      Title: NKIAMRE, a novel conserved CDC2-related kinase with features of both mitogen-activated protein kinases and cyclin-dependent kinases.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    cyclin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    protein modification process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    cyclin-dependent kinase-like 3
    Names
    cyclin-dependent kinase-like 3
    serine-threonine protein kinase NKIAMRE
    serine/threonine-protein kinase NKIAMRE
    NP_001107047.1
    NP_057592.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113575.1 → NP_001107047.1  cyclin-dependent kinase-like 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC041799, BX104333
      Consensus CDS
      CCDS47264.1
      UniProtKB/Swiss-Prot
      Q8IVW4
      Related
      ENSP00000265334, OTTHUMP00000226137, ENST00000265334, OTTHUMT00000377697
      Conserved Domains (2) summary
      cd07846
      Location:2 – 286
      Blast Score: 1361
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
      smart00220
      Location:4 – 286
      Blast Score: 706
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    2. NM_016508.3 → NP_057592.2  cyclin-dependent kinase-like 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The encoded protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AF130372, BC041799
      Consensus CDS
      CCDS47265.1
      UniProtKB/Swiss-Prot
      Q8IVW4
      Related
      ENSP00000395559, ENST00000435211
      Conserved Domains (2) summary
      cd07846
      Location:2 – 286
      Blast Score: 1360
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
      smart00220
      Location:4 – 286
      Blast Score: 697
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      133634115..133702765, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      128818996..128887557, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC104109.3 None
    genomic AC109454.3 (18710..62063) None
    genomic CH471062.2 EAW62263.1
      EAW62264.1
      EAW62265.1
      EAW62266.1
    mRNA AF087989.1 None
    mRNA AF130372.1 AAF36509.1
    mRNA AK294559.1 BAH11811.1
    mRNA AK294740.1 BAG57883.1
    mRNA AK297586.1 BAG59974.1
    mRNA AK299305.1 BAG61318.1
    mRNA AK301802.1 BAG63253.1
    mRNA AK310955.1 None
    mRNA BC041799.1 AAH41799.1
    mRNA BX104333.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IVW4.1 GenPept UniProtKB/Swiss-Prot:Q8IVW4
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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