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PER2 period circadian regulator 2 [ Bos taurus (cattle) ]

Gene ID: 512237, updated on 3-Apr-2024

Summary

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Official Symbol
PER2provided by VGNC
Official Full Name
period circadian regulator 2provided by VGNC
Primary source
VGNC:VGNC:106859
See related
BGD:BT24722; Ensembl:ENSBTAG00000001879
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Summary
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]
Orthologs
human mouse all
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Genomic context

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See PER2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (117557012..117599734, complement)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene ILK associated serine/threonine phosphatase Neighboring gene uncharacterized LOC132344956 Neighboring gene hes family bHLH transcription factor 6 Neighboring gene uncharacterized LOC132344957 Neighboring gene TRAF3 interacting protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Circadian Clock genes Per2 and clock regulate steroid production, cell proliferation, and luteinizing hormone receptor transcription in ovarian granulosa cells. Shimizu T, et al. Biochem Biophys Res Commun, 2011 Aug 19. PMID 21819971
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these data provide a new insight that Per2 and Clock have different action on ovarian granulosa cell functions.
    Title: Circadian Clock genes Per2 and clock regulate steroid production, cell proliferation, and luteinizing hormone receptor transcription in ovarian granulosa cells.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription corepressor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in circadian regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in entrainment of circadian clock by photoperiod IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
period circadian protein homolog 2
Names
period circadian clock 2
period homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001192317.1 → NP_001179246.1  period circadian protein homolog 2

    See identical proteins and their annotated locations for NP_001179246.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000003
    UniProtKB/TrEMBL
    F1N4I4, G3N0M5
    Conserved Domains (4) summary
    cd00130
    Location:333 → 434
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam12114
    Location:1080 → 1251
    Period_C; Period protein 2/3C-terminal region
    cl26386
    Location:538 → 716
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:822 → 1059
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    117557012..117599734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024987696.2 → XP_024843464.1  period circadian protein homolog 2 isoform X1

    UniProtKB/TrEMBL
    F1N4I4
    Related
    ENSBTAP00000002448.6, ENSBTAT00000002448.7
    Conserved Domains (4) summary
    cd00130
    Location:327 → 428
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam12114
    Location:1074 → 1245
    Period_C; Period protein 2/3C-terminal region
    cl26386
    Location:532 → 710
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:816 → 1053
    Atrophin-1; Atrophin-1 family

  2. XM_024987697.2 → XP_024843465.1  period circadian protein homolog 2 isoform X2

    UniProtKB/TrEMBL
    F1N4I4, G3N0M5
    Related
    ENSBTAP00000055391.2, ENSBTAT00000063277.3
    Conserved Domains (4) summary
    cd00130
    Location:333 → 434
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam12114
    Location:1080 → 1251
    Period_C; Period protein 2/3C-terminal region
    cl26386
    Location:538 → 716
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:822 → 1059
    Atrophin-1; Atrophin-1 family

  3. XM_059883534.1 → XP_059739517.1  period circadian protein homolog 2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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