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    NUSAP1 nucleolar and spindle associated protein 1 [ Homo sapiens ]

    Gene ID: 51203, updated on 11-May-2012
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    Summary

    Official Symbol
    NUSAP1provided by HGNC
    Official Full Name
    nucleolar and spindle associated protein 1provided by HGNC
    Primary source
    HGNC:18538
    Locus tag
    BM-037
    See related
    Ensembl:ENSG00000137804; MIM:612818; Vega:OTTHUMG00000172588
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LNP; ANKT; SAPL; BM037; NUSAP; Q0310; PRO0310p1; FLJ13421
    Summary
    NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009]
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    Genomic context

    Location :
    15q15.1
    Sequence :
    Chromosome: 15; NC_000015.9 (41624926..41673248)
    See NUSAP1 in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene OIP5 antisense RNA 1 (non-protein coding) Neighboring gene Opa interacting protein 5 Neighboring gene NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 Neighboring gene Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. SAP-like domain in nucleolar spindle associated protein mediates mitotic chromosome loading as well as interphase chromatin interaction. Verbakel W, et al. Biochem Biophys Res Commun, 2011 Aug 12. PMID 21782797.
    2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    3. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068.
    4. Antibodies specifically target AML antigen NuSAP1 after allogeneic bone marrow transplantation. Wadia PP, et al. Blood, 2010 Mar 11. PMID 20053754.
    5. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Jeronimo C, et al. Mol Cell, 2007 Jul 20. PMID 17643375.

    See all (12) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Interphase NuSAP-chromatin interaction suggests additional functions for NuSAP, as recently identified for other nuclear spindle assembly factors with a role in gene expression or DNA damage response.
      Title: SAP-like domain in nucleolar spindle associated protein mediates mitotic chromosome loading as well as interphase chromatin interaction.
    2. NuSAP1 is recognized as an immunogenic antigen in 65% of patients with AML following allogeneic HCT and suggests a tumor antigen role.
      Title: Antibodies specifically target AML antigen NuSAP1 after allogeneic bone marrow transplantation.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:119376 BioGRID:128436 KHDRBS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119376 BioGRID:202582 Ranbp2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119376 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytokinesis after mitosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    establishment of mitotic spindle localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitotic chromosome condensation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitotic sister chromatid segregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of mitosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    nucleolar and spindle-associated protein 1
    Names
    nucleolar and spindle-associated protein 1
    nucleolar protein ANKT
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243142.1 → NP_001230071.1  nucleolar and spindle-associated protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in both the 5' and central coding regions, compared to variant 1, resulting in an isoform (4) that is 2 aa shorter than isoform 1.
      Source sequence(s)
      AK222819, BC024772, DB046574, DB047195
      UniProtKB/Swiss-Prot
      Q9BXS6

    2. NM_001243143.1 → NP_001230072.1  nucleolar and spindle-associated protein 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (5) that is shorter than isoform 1.
      Source sequence(s)
      AC087721, AK222819, AL833611, DB046574, DB047195
      UniProtKB/Swiss-Prot
      Q9BXS6

    3. NM_001243144.1 → NP_001230073.1  nucleolar and spindle-associated protein 1 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon in both the 5' and 3' coding regions, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.
      Source sequence(s)
      AC087721, AK222819, AK293168, BC001308, DB046574, DB047195
      UniProtKB/TrEMBL
      B4DDF1
      UniProtKB/TrEMBL
      E7ERR5
      UniProtKB/Swiss-Prot
      Q9BXS6

    4. NM_016359.4 → NP_057443.2  nucleolar and spindle-associated protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF290612, AK222819, DB046574, DB047195
      Consensus CDS
      CCDS45234.1
      UniProtKB/Swiss-Prot
      Q9BXS6
      Related
      ENSP00000453403, OTTHUMP00000248843, ENST00000559596, OTTHUMT00000419427

    5. NM_018454.7 → NP_060924.4  nucleolar and spindle-associated protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      AK222819, BC001308, DB046574, DB047195
      Consensus CDS
      CCDS45236.1
      UniProtKB/Swiss-Prot
      Q9BXS6
      Related
      ENSP00000400746, OTTHUMP00000248799, ENST00000414849, OTTHUMT00000419329

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p5 Primary Assembly

      Range
      41624926..41673248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      18473371..18521702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001129897.1: Suppressed sequence

      Description
      NM_001129897.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC087721.4 (19940..68117) None
    genomic CH471125.1 EAW92482.1
      EAW92483.1
      EAW92484.1
      EAW92485.1
      EAW92486.1
    mRNA AF090915.1 AAF24034.1
    mRNA AF217513.1 AAF67624.1
    mRNA AF290612.1 AAK28023.1
    mRNA AF305711.1 AAG25874.1
    mRNA AK023483.1 BAB14586.1
    mRNA AK222819.1 BAD96539.1
    mRNA AK225703.1 None
    mRNA AK290879.1 BAF83568.1
    mRNA AK293168.1 BAG56712.1
    mRNA AK307728.1 None
    mRNA AL833611.1 None
    mRNA BC001308.1 AAH01308.1
    mRNA BC010838.1 AAH10838.2
    mRNA BC011008.1 None
    mRNA BC012887.1 AAH12887.2
    mRNA BC024772.1 AAH24772.1
    mRNA BG259258.1 None
    mRNA DB046574.1 None
    mRNA DB047195.1 None
    other-genetic DQ891588.2 ABM82514.1
    other-genetic DQ894782.2 ABM85708.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BXS6.1 GenPept UniProtKB/Swiss-Prot:Q9BXS6
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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