ZNF639 zinc finger protein 639 [Homo sapiens] - Gene

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Summary

Official Symbol: ZNF639provided by HGNC
Official Full Name: zinc finger protein 639provided by HGNC
Primary source: HGNC:30950
See related: Ensembl:ENSG00000121864; HPRD:15882; Vega:OTTHUMG00000157439
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZASC1; ANC-2H01; ANC_2H01; 6230400O18Rik

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Genomic context

Location :: 3q26.33

Sequence :: Chromosome: 3; NC_000003.11 (179041551..179053320)

See ZNF639 in Epigenomics, MapViewer

Chromosome 3 - NC_000003.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ZASC1 copy number that increased from primary to recurrent tumor suggested the importance of ZASC1 in tumor progression. The increase of ZASC1 gene copy number in recurrent tumors was associated with the consumption of betel quid in patients.
Title: Increase of ZASC1 gene copy number in recurrent oral carcinoma.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q9UID6	Q7Z2E3	APTX	HPRD	PubMed
Q9UID6	Q92793	CREBBP	HPRD	PubMed
BioGRID:119367	BioGRID:107777	CREBBP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:119367	BioGRID:121649	WDR48	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein self-association	IPI Inferred from Physical Interaction more info
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
initiation of viral infection	IDA Inferred from Direct Assay more info
negative regulation by host of viral transcription	IMP Inferred from Mutant Phenotype more info
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
positive regulation by host of viral transcription	IMP Inferred from Mutant Phenotype more info
positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
intracellular	IEA Inferred from Electronic Annotation more info
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: zinc finger protein 639

Names: zinc finger protein 639; zinc finger protein ZASC1; zinc finger protein ANC_2H01; zinc finger amplified in esophageal squamous cell carcinomas 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016331.1 → NP_057415.1 zinc finger protein 639

Status: PROVISIONAL

Source sequence(s)

AF003924

Consensus CDS

CCDS3227.1

UniProtKB/Swiss-Prot

Q9UID6

Related

ENSP00000325634, OTTHUMP00000212174, ENST00000326361, OTTHUMT00000348855

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000003.11 Reference GRCh37.p5 Primary Assembly

Range

179041551..179053320

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000135.1 Alternate HuRef

Range

176444494..176456448

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC007823.38 (76029..87798)	None
genomic	CH471052.2	EAW78413.1
		EAW78414.1
		EAW78415.1
		EAW78416.1
mRNA	AB097862.1	BAC77610.1
mRNA	AF003924.1	AAF21240.1
mRNA	BC020500.1	AAH20500.1
mRNA	BC026181.1	AAH26181.1
mRNA	DQ323613.1	ABD27860.1
other-genetic	EU446802.1	ABZ92331.1