LEF1 lymphoid enhancer-binding factor 1 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: LEF1provided by HGNC
Official Full Name: lymphoid enhancer-binding factor 1provided by HGNC
Primary source: HGNC:6551
See related: Ensembl:ENSG00000138795; HPRD:01075; MIM:153245; Vega:OTTHUMG00000131809
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LEF-1; TCF10; TCF7L3; TCF1ALPHA
Summary: This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Genomic context

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Location :: 4q23-q25

Sequence :: Chromosome: 4; NC_000004.11 (108968701..109090112, complement)

See LEF1 in Epigenomics, MapViewer

Chromosome 4 - NC_000004.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

LEF-1 might play an important role in colon carcinogenesis by acting as a regulator.
Title: The balance between two isoforms of LEF-1 regulates colon carcinoma growth.
Lef1 is overexpressed in human endometrial tumors, consistent with it playing a role in gland proliferation.
Title: The role of LEF1 in endometrial gland formation and carcinogenesis.
An association between the maternal genotype and the occurrence of cleft lip or palate was observed at two polymorphic loci (rs10022956 and rs10025431), while a foetal-maternal effect modulating the risk of clefting was found at locus rs10025431.
Title: Evidence of LEF1 fetal-maternal interaction in cleft lip with or without cleft palate in a consistent Italian sample study.
n-Butyl benzyl phthalate promotes breast cancer progression by inducing expression of lymphoid enhancer factor 1
Title: n-Butyl benzyl phthalate promotes breast cancer progression by inducing expression of lymphoid enhancer factor 1.
Results suggest that NDRG2 and prenylated Rab acceptor-1 (PRA1) might act synergistically to prevent signaling of T-cell facto/beta-catenin.
Title: NDRG2 and PRA1 interact and synergistically inhibit T-cell factor/β-catenin signaling.
interaction of HCLS1 with LEF-1 is essential for G-CSF-triggered myeloid differentiation
Title: Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.
High LEF1 expression is associated with significantly better relapse-free survival, overall survival, and event-free survival of cytogenetically normal acute myeloid leukemia patients.
Title: High expression of lymphoid enhancer-binding factor-1 (LEF1) is a novel favorable prognostic factor in cytogenetically normal acute myeloid leukemia.
miR-218 is involved in the invasive behavior of glioblastoma cells by targeting LEF1 and blocking the invasive axis.
Title: MiR-218 reverses high invasiveness of glioblastoma cells by targeting the oncogenic transcription factor LEF1.
our results indicate a pivotal role of LEF-1 in the regulation of proliferation and MMP-7 transcription in breast cancer cells.
Title: LEF-1 regulates proliferation and MMP-7 transcription in breast cancer cells.
findings suggest that transcriptional activation of LEF1 is a mechanism of cross talk between HGF/c-Met and Wnt/beta-catenin pathways and is essential for HGF-induced tumor invasion
Title: Hepatocyte growth factor activates Wnt pathway by transcriptional activation of LEF1 to facilitate tumor invasion.

Submit: New GeneRIF Correction See all (81)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese.

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Tat, p14	tat	HIV-1 Tat and methamphetamine suppresses expression of LEF-1, a key partner of -catenin to regulate cognate gene expression	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_057353.1	NP_001895.1	CTNNB1	BIND	PubMed	LEF-1 interacts with Beta-catenin. This interaction was modeled on a demonstrated interaction between human LEF-1 and mouse Beta-catenin.
NP_057353.1	NP_005893.1	SMAD3	BIND	PubMed	Lef1 interacts with Smad3. This interaction was modeled on a demonstrated interaction between mouse Lef1 and Smad3 from an unspecified species.
NP_057353.1	NP_005068.2	TLE1	BIND	PubMed	LEF-1 interacts with TLE1. This interaction was modeled on a demonstrated interaction between LEF-1 from an unspecified species and human TLE1.
Q9UJU2	Q9H161	ALX4	HPRD	PubMed
Q9UJU2	Q86V81	ALYREF	HPRD	PubMed
Q9UJU2	P47902	CDX1	HPRD	PubMed
Q9UJU2	P35222	CTNNB1	HPRD	PubMed
Q9UJU2	Q09472	EP300	HPRD	PubMed
Q9UJU2	P52294	KPNA1	HPRD	PubMed
Q9UJU2	P52292	KPNA2	HPRD	PubMed
Q9UJU2	O75030	MITF	HPRD	PubMed
Q9UJU2	Q9UBE8	NLK	HPRD	PubMed
Q9UJU2	P46531	NOTCH1	HPRD	PubMed
Q9UJU2	Q8N2W9	PIAS4	HPRD	PubMed
Q9UJU2	Q99697	PITX2	HPRD	PubMed
Q9UJU2	Q13950	RUNX2	HPRD	PubMed
Q9UJU2	Q15797	SMAD1	HPRD	PubMed
Q9UJU2	Q15796	SMAD2	HPRD	PubMed
Q9UJU2	P84022	SMAD3	HPRD	PubMed
Q9UJU2	Q13485	SMAD4	HPRD	PubMed
Q9UJU2	P61956	SUMO2	HPRD	PubMed
Q9UJU2	Q04724	TLE1	HPRD	PubMed
Q9UJU2	P17480	UBTF	HPRD	PubMed
Q9UJU2	T cell antigen receptor, alpha		HPRD	PubMed
BioGRID:119354	BioGRID:115486	ALYREF	BioGRID	PubMed	Reconstituted Complex
BioGRID:119354	BioGRID:107880	CTNNB1	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
BioGRID:119354	BioGRID:119486	DACT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119354	BioGRID:115143	DAZAP2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119354	BioGRID:108142	DPYSL2	BioGRID	PubMed	Two-hybrid
BioGRID:119354	BioGRID:108201	E2F1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119354	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:119354	BioGRID:108563	FHIT	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119354	BioGRID:109315	HDAC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119354	BioGRID:109341	HINT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119354	BioGRID:201006	Kpna1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:119354	BioGRID:201007	Kpna2	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:119354	BioGRID:110432	MITF	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:119354	BioGRID:110687	MYB	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119354	BioGRID:119685	NLK	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:119354	BioGRID:110913	NOTCH1	BioGRID	PubMed	Reconstituted Complex
BioGRID:119354	BioGRID:119624	PIAS4	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:119354	BioGRID:114166	RUVBL1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119354	BioGRID:132490	SETD8	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:119354	BioGRID:110262	SMAD2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:119354	BioGRID:110263	SMAD3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:119354	BioGRID:110264	SMAD4	BioGRID	PubMed	Reconstituted Complex
BioGRID:119354	BioGRID:110267	SMAD7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119354	BioGRID:112943	TLE1	BioGRID	PubMed	Co-crystal Structure; Reconstituted Complex
BioGRID:119354	BioGRID:112944	TLE2	BioGRID	PubMed	Reconstituted Complex
BioGRID:119354	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:119354	BioGRID:113190	UBTF	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119354	BioGRID:122933	ZBTB3	BioGRID	PubMed	Two-hybrid
BioGRID:119354	BioGRID:105397	nrarp	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119354	BioGRID:98801	ubc	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Acute myeloid leukemia, organism-specific biosystem (from KEGG)
Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
Acute myeloid leukemia, conserved biosystem (from KEGG)
Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
Adherens junction, organism-specific biosystem (from KEGG)
Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
Adherens junction, conserved biosystem (from KEGG)
Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
Arrhythmogenic right ventricular cardiomyopathy, organism-specific biosystem (from WikiPathways)
Arrhythmogenic right ventricular cardiomyopathy, organism-specific biosystemAdapted from KEGG: http://www.genome.jp/kegg/pathway/hsa/hsa05412.html
Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
Basal cell carcinoma, organism-specific biosystem (from KEGG)
Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
Basal cell carcinoma, conserved biosystem (from KEGG)
Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
C-MYB transcription factor network, organism-specific biosystem
C-MYB transcription factor network
Colorectal cancer, organism-specific biosystem (from KEGG)
Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
Colorectal cancer, conserved biosystem (from KEGG)
Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
Endometrial cancer, organism-specific biosystem (from KEGG)
Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
Endometrial cancer, conserved biosystem (from KEGG)
Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
Hippo signaling pathway, organism-specific biosystem (from KEGG)
Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
Hippo signaling pathway, conserved biosystem (from KEGG)
Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
Melanogenesis, organism-specific biosystem (from KEGG)
Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
Melanogenesis, conserved biosystem (from KEGG)
Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Prostate cancer, organism-specific biosystem (from KEGG)
Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
Prostate cancer, conserved biosystem (from KEGG)
Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
Regulation of Wnt-mediated beta catenin signaling and target gene transcription
TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
Thyroid cancer, organism-specific biosystem (from KEGG)
Thyroid cancer, organism-specific biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
Thyroid cancer, conserved biosystem (from KEGG)
Thyroid cancer, conserved biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
Wnt signaling pathway, organism-specific biosystem (from KEGG)
Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Wnt signaling pathway, conserved biosystem (from KEGG)
Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

General gene information

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Markers

RH122898 (e-PCR)
- UniSTS:135195

SHGC-154060 (e-PCR)
- UniSTS:183869

SHGC-18750 (e-PCR)
- UniSTS:27458

Lef1 (e-PCR), detects polymorphism
- UniSTS:499097

LEF1_1628 (e-PCR)
- UniSTS:277449

SHGC-18753 (e-PCR)
- UniSTS:3285

RH121496 (e-PCR)
- UniSTS:134623

Genotypes

See LEF1 SNP Geneview Report
See LEF1 SNP Genotype Report
See LEF1 SNP Variation Viewer Report

Homology

Homologs of the LEF1 gene: The LEF1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and mosquito.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
C2H2 zinc finger domain binding	IPI Inferred from Physical Interaction more info	PubMed
DNA binding	ISS Inferred from Sequence or Structural Similarity more info
DNA binding, bending	ISS Inferred from Sequence or Structural Similarity more info
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
RNA polymerase II regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IMP Inferred from Mutant Phenotype more info
armadillo repeat domain binding	IPI Inferred from Physical Interaction more info	PubMed
beta-catenin binding	IDA Inferred from Direct Assay more info	PubMed
beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
beta-catenin binding	TAS Traceable Author Statement more info	PubMed
chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info
enhancer binding	IDA Inferred from Direct Assay more info	PubMed
estrogen receptor activity	IDA Inferred from Direct Assay more info	PubMed
estrogen receptor binding	IDA Inferred from Direct Assay more info	PubMed
gamma-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
histone binding	IPI Inferred from Physical Interaction more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
transcription factor binding	IEA Inferred from Electronic Annotation more info
transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
B cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
T cell receptor V(D)J recombination	IEA Inferred from Electronic Annotation more info
T-helper 1 cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
Wnt receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
alpha-beta T cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
anatomical structure regression	IEA Inferred from Electronic Annotation more info
apoptotic process involved in morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
brain development	IBA Inferred from Biological aspect of Ancestor more info
canonical Wnt receptor signaling pathway	IDA Inferred from Direct Assay more info
canonical Wnt receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
cellular response to cytokine stimulus	IMP Inferred from Mutant Phenotype more info
cellular response to interleukin-4	IDA Inferred from Direct Assay more info	PubMed
chorio-allantoic fusion	IBA Inferred from Biological aspect of Ancestor more info
dentate gyrus development	IBA Inferred from Biological aspect of Ancestor more info
embryonic limb morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
eye pigmentation	IBA Inferred from Biological aspect of Ancestor more info
face morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
forebrain neuroblast division	IBA Inferred from Biological aspect of Ancestor more info
forebrain neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
forebrain radial glial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
formation of radial glial scaffolds	IBA Inferred from Biological aspect of Ancestor more info
generation of neurons	IBA Inferred from Biological aspect of Ancestor more info
histone H3 acetylation	IMP Inferred from Mutant Phenotype more info
histone H4 acetylation	IMP Inferred from Mutant Phenotype more info
hypothalamus development	IBA Inferred from Biological aspect of Ancestor more info
induction of apoptosis	IBA Inferred from Biological aspect of Ancestor more info
mammary gland development	IBA Inferred from Biological aspect of Ancestor more info
muscle fiber development	IBA Inferred from Biological aspect of Ancestor more info
negative regulation of DNA binding	IDA Inferred from Direct Assay more info	PubMed
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info
negative regulation of apoptotic process in bone marrow	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of canonical Wnt receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info
negative regulation of estrogen receptor binding	IDA Inferred from Direct Assay more info	PubMed
negative regulation of interleukin-13 production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of interleukin-4 production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of interleukin-5 production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of striated muscle tissue development	IEA Inferred from Electronic Annotation more info
negative regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
neural crest cell migration	IBA Inferred from Biological aspect of Ancestor more info
neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
neutrophil differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
odontoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
osteoblast differentiation	IEP Inferred from Expression Pattern more info
palate development	ISS Inferred from Sequence or Structural Similarity more info
paraxial mesoderm formation	IBA Inferred from Biological aspect of Ancestor more info
patterning of blood vessels	IBA Inferred from Biological aspect of Ancestor more info
positive regulation by host of viral transcription	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell cycle process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info
positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info
positive regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell proliferation in bone marrow	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info
positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
positive regulation of granulocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of granulocyte differentiation	IMP Inferred from Mutant Phenotype more info
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
regulation of striated muscle tissue development	IBA Inferred from Biological aspect of Ancestor more info
sensory perception of taste	IEA Inferred from Electronic Annotation more info
somitogenesis	IBA Inferred from Biological aspect of Ancestor more info
sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
tongue development	IEA Inferred from Electronic Annotation more info
trachea gland development	IBA Inferred from Biological aspect of Ancestor more info
transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
nucleus	IC Inferred by Curator more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
protein-DNA complex	IDA Inferred from Direct Assay more info	PubMed
transcription factor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lymphoid enhancer-binding factor 1

Names: lymphoid enhancer-binding factor 1; TCF1-alpha; T cell-specific transcription factor 1-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_015798.1 RefSeqGene

Range

5001..126412

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001130713.2 → NP_001124185.1 lymphoid enhancer-binding factor 1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.

Source sequence(s)

AC097067, AC118062, AF288571, AK225772, AL049409

Consensus CDS

CCDS47123.1

UniProtKB/TrEMBL

Q659G9

UniProtKB/Swiss-Prot

Q9UJU2

Conserved Domains (2) summary

cd01388
Location:270 – 341
Blast Score: 280

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 – 213
Blast Score: 522

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001130714.2 → NP_001124186.1 lymphoid enhancer-binding factor 1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks both an in-frame exon in the central coding region and an exon in the 3' coding region that causes a frameshift, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AC097067, AF288571, AK225772, AL049409, BC040559

Consensus CDS

CCDS47122.1

UniProtKB/TrEMBL

Q659G9

UniProtKB/Swiss-Prot

Q9UJU2

Related

ENSP00000369284, ENST00000379951

Conserved Domains (2) summary

cd01388
Location:270 – 341
Blast Score: 280

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 – 213
Blast Score: 524

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001166119.1 → NP_001159591.1 lymphoid enhancer-binding factor 1 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC118062, AF288571, AK303272, AL049409, DC405840, DC406065

Consensus CDS

CCDS54791.1

UniProtKB/TrEMBL

Q659G9

UniProtKB/Swiss-Prot

Q9UJU2

Conserved Domains (2) summary

cd01388
Location:202 – 273
Blast Score: 275

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:3 – 145
Blast Score: 371

CTNNB1_binding; N-terminal CTNNB1 binding
NM_016269.4 → NP_057353.1 lymphoid enhancer-binding factor 1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC097067, AF288571, AK225772, AL049409, BC050632

Consensus CDS

CCDS3679.1

UniProtKB/TrEMBL

Q659G9

UniProtKB/Swiss-Prot

Q9UJU2

Related

ENSP00000265165, OTTHUMP00000162624, ENST00000265165, OTTHUMT00000254749

Conserved Domains (2) summary

cd01388
Location:298 – 369
Blast Score: 283

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 – 213
Blast Score: 517

CTNNB1_binding; N-terminal CTNNB1 binding

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000004.11 Reference GRCh37.p10 Primary Assembly

Range

108968701..109090112, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000136.1 Alternate HuRef

Range

104700344..104821596, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018915.1 Alternate CHM1_1.0

Range

108763744..108885438, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01063757.1 (21592..62861)	None
genomic	ABBA01063758.1	None
genomic	ABBA01063759.1	None
genomic	AC092539.5 (1999..25022)	None
genomic	AC097067.3	None
genomic	AC118062.4 (50589..105609)	None
genomic	AC123576.4	None
genomic	AF203908.1	None
genomic	AMYH01014451.1 (488535..518576)	None
genomic	AMYH01014452.1	None
genomic	AMYH01014453.1	None
genomic	AY129650.1	AAN06089.1
genomic	CH471057.1	EAX06221.1
		EAX06222.1
		EAX06223.1
		EAX06224.1
		EAX06225.1
genomic	JN232202.1	AEW16365.1
mRNA	AF086339.1	None
mRNA	AF198532.1	AAF13268.1
mRNA	AF288571.1	AAG01022.1
mRNA	AF294627.1	AAG26886.1
mRNA	AK128255.1	None
mRNA	AK225772.1	None
mRNA	AK294395.1	BAG57649.1
mRNA	AK303143.1	BAG64247.1
mRNA	AK303272.1	BAH13928.1
mRNA	AL049409.1	CAH56421.1
mRNA	BC040559.1	AAH40559.1
mRNA	BC050632.2	AAH50632.1
mRNA	DC405840.1	None
mRNA	DC406065.1	None
other-genetic	EU446873.1	ABZ92402.1