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HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 [ Homo sapiens (human) ]

Gene ID: 51170, updated on 8-May-2016
Official Symbol
HSD17B11provided by HGNC
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 11provided by HGNC
Primary source
HGNC:HGNC:22960
See related
Ensembl:ENSG00000198189 HPRD:10881; MIM:612831; Vega:OTTHUMG00000130594
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHRS8; PAN1B; RETSDR2; SDR16C2; 17BHSD11; 17-BETA-HSD11; 17-BETA-HSDXI
Summary
Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]
Orthologs
Location:
4q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (87336522..87391303, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (88257691..88312455, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene microRNA 5705 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 13 Neighboring gene mitochondrial ribosomal protein L19 pseudogene Neighboring gene nudix hydrolase 9

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic variants associated with disordered eating.
NHGRI GWA Catalog
  • Estrogen biosynthesis, organism-specific biosystem (from REACTOME)
    Estrogen biosynthesis, organism-specific biosystemIn female vertebrates, estrogens control reproductive system development and reproductive functions (Payne AH and Hales DB, 2004).
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Metabolism of steroid hormones, organism-specific biosystem (from REACTOME)
    Metabolism of steroid hormones, organism-specific biosystemSteroid hormones are synthesized primarily in the adrenal gland and gonads. They regulate energy metabolism and stress responses (glucocorticoids), salt balance (mineralocorticoids), and sexual devel...
  • estradiol biosynthesis I, organism-specific biosystem (from BIOCYC)
    estradiol biosynthesis I, organism-specific biosystemEstrogens are estrone and estradiol, steroid hormones synthesized in the ovaries, breasts, adipose and other tissues that are critical for sexual development and function. They can also act as induce...
  • superpathway of steroid hormone biosynthesis, organism-specific biosystem (from BIOCYC)
    superpathway of steroid hormone biosynthesis, organism-specific biosystemAs their name implies, : Steroid-Hormones "steroid hormones" are steroids that act as hormones. Steroid hormones are divided into five groups based on the receptors to which they bind: : Glucocortico...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
estradiol 17-beta-dehydrogenase activity TAS
Traceable Author Statement
more info
 
steroid dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
androgen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
estrogen biosynthetic process TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lipid particle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
estradiol 17-beta-dehydrogenase 11
Names
17-beta-hydroxysteroid dehydrogenase type XI
CTCL tumor antigen HD-CL-03
CTCL-associated antigen HD-CL-03
cutaneous T-cell lymphoma-associated antigen HD-CL-03
dehydrogenase/reductase SDR family member 8
retinal short-chain dehydrogenase/reductase 2
short chain dehydrogenase/reductase family 16C member 2
short chain dehydrogenase/reductase family 16C, member 2
NP_057329.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016245.4NP_057329.3  estradiol 17-beta-dehydrogenase 11 precursor

    See identical proteins and their annotated locations for NP_057329.3

    Status: VALIDATED

    Source sequence(s)
    AF273056, BC014327, BM976691, BU838518
    Consensus CDS
    CCDS3619.1
    UniProtKB/Swiss-Prot
    Q8NBQ5
    Related
    ENSP00000351035, OTTHUMP00000161168, ENST00000358290, OTTHUMT00000253041
    Conserved Domains (2) summary
    PRK07825
    Location:33285
    PRK07825; short chain dehydrogenase; Provisional
    cd05339
    Location:38277
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    87336522..87391303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714232.1XP_006714295.1  

    UniProtKB/TrEMBL
    D6RCD0
    Related
    ENSP00000423775, OTTHUMP00000219651, ENST00000507286, OTTHUMT00000363603
    Conserved Domains (2) summary
    PRK07825
    Location:33241
    PRK07825; short chain dehydrogenase; Provisional
    cd05339
    Location:38233
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
  2. XM_011532021.1XP_011530323.1  

    Conserved Domains (1) summary
    cl21454
    Location:38150
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    88234774..88289311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)