Format

Send to:

Choose Destination

INSIG2 insulin induced gene 2 [ Homo sapiens (human) ]

Gene ID: 51141, updated on 8-May-2016
Official Symbol
INSIG2provided by HGNC
Official Full Name
insulin induced gene 2provided by HGNC
Primary source
HGNC:HGNC:20452
See related
Ensembl:ENSG00000125629 HPRD:16361; MIM:608660; Vega:OTTHUMG00000058518
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INSIG-2
Summary
The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]
Orthologs
Location:
2q14.2
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (118088474..118110027)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (118846033..118867604)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929908 Neighboring gene coiled-coil domain containing 93 Neighboring gene uncharacterized LOC102723413 Neighboring gene uncharacterized LOC105373988 Neighboring gene uncharacterized LOC100506797 Neighboring gene uncharacterized LOC105373578

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
NHGRI GWA Catalog
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Regulation of cholesterol biosynthesis by SREBP (SREBF), organism-specific biosystem (from REACTOME)
    Regulation of cholesterol biosynthesis by SREBP (SREBF), organism-specific biosystemSterol regulatory element binding proteins (SREBPs, SREBFs) respond to low cholesterol concentrations by transiting to the nucleus and activating genes involved in cholesterol and lipid biosynthesis ...
  • SREBP signalling, organism-specific biosystem (from WikiPathways)
    SREBP signalling, organism-specific biosystemSterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcript...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC26273

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
SREBP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cranial suture morphogenesis IEA
Inferred from Electronic Annotation
more info
 
inner ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
middle ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
palate development IEA
Inferred from Electronic Annotation
more info
 
response to fatty acid IEA
Inferred from Electronic Annotation
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
triglyceride metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
SREBP-SCAP-Insig complex IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
Preferred Names
insulin-induced gene 2 protein
Names
INSIG2 membrane protein
insulin induced protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321329.1NP_001308258.1  insulin-induced gene 2 protein isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) and variant 1 both encode the same isoform (a).
    Source sequence(s)
    AC009303, AF527632, AW264638, BE888848
    Conserved Domains (1) summary
    pfam07281
    Location:28211
    INSIG; Insulin-induced protein (INSIG)
  2. NM_001321330.1NP_001308259.1  insulin-induced gene 2 protein isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) and variants 4 and 5 all encode the same isoform (b).
    Source sequence(s)
    AC009303, AF527632, AW264638, DC364733, HY053967
    Conserved Domains (1) summary
    pfam07281
    Location:1103
    INSIG; Insulin-induced protein (INSIG)
  3. NM_001321331.1NP_001308260.1  insulin-induced gene 2 protein isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) and variants 3 and 5 all encode the same isoform (b).
    Source sequence(s)
    AC009303, AF527632, AW264638, BX647805, HY053967
    Conserved Domains (1) summary
    pfam07281
    Location:1103
    INSIG; Insulin-induced protein (INSIG)
  4. NM_001321332.1NP_001308261.1  insulin-induced gene 2 protein isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) and variants 3 and 4 all encode the same isoform (b).
    Source sequence(s)
    AC009303, AF527632, AW264638, BE888848, BX647805
    Conserved Domains (1) summary
    pfam07281
    Location:1103
    INSIG; Insulin-induced protein (INSIG)
  5. NM_001321333.1NP_001308262.1  insulin-induced gene 2 protein isoform c

    Status: REVIEWED

    Source sequence(s)
    AC009303, AF527632, AK021692, AW264638, HY053967
    Conserved Domains (1) summary
    pfam07281
    Location:173
    INSIG; Insulin-induced protein (INSIG)
  6. NM_016133.3NP_057217.2  insulin-induced gene 2 protein isoform a

    See identical proteins and their annotated locations for NP_057217.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variant 2 both encode the same isoform (a).
    Source sequence(s)
    AC009303, AF527632, AW264638, HY053967
    Consensus CDS
    CCDS2122.1
    UniProtKB/Swiss-Prot
    Q9Y5U4
    UniProtKB/TrEMBL
    A0A024RAI2
    Related
    ENSP00000245787, OTTHUMP00000064464, ENST00000245787, OTTHUMT00000129624
    Conserved Domains (1) summary
    pfam07281
    Location:28211
    INSIG; Insulin-induced protein (INSIG)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    118088474..118110027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263690.2XP_005263747.1  

    UniProtKB/TrEMBL
    B4DQ23
    Conserved Domains (1) summary
    pfam07281
    Location:1103
    INSIG; Insulin-induced protein (INSIG)
  2. XM_011511292.1XP_011509594.1  

    UniProtKB/Swiss-Prot
    Q9Y5U4
    UniProtKB/TrEMBL
    A0A024RAI2
    Related
    ENSP00000484179, ENST00000614681
    Conserved Domains (1) summary
    pfam07281
    Location:28211
    INSIG; Insulin-induced protein (INSIG)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    118849883..118871052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)