Display Settings:

Format

Send to:

Choose Destination

IRAK4 interleukin-1 receptor-associated kinase 4 [ Homo sapiens (human) ]

Gene ID: 51135, updated on 23-Oct-2014
Official Symbol
IRAK4provided by HGNC
Official Full Name
interleukin-1 receptor-associated kinase 4provided by HGNC
Primary source
HGNC:HGNC:17967
Locus tag
RP11-210N13.4
See related
Ensembl:ENSG00000198001; HPRD:06051; MIM:606883
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IPD1; REN64; IRAK-4; NY-REN-64
Summary
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
See IRAK4 in Epigenomics, MapViewer
Location:
12q12
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (43758944..43789543)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (44152747..44183346)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 17 Neighboring gene pseudouridylate synthase 7 homolog (S. cerevisiae)-like Neighboring gene twinfilin actin-binding protein 1 Neighboring gene transmembrane protein 117 Neighboring gene zinc finger protein 75B, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Invasive pneumococcal disease, recurrent isolated, 1
MedGen: C1835828 OMIM: 610799 GeneReviews: Not available
Compare labs
IRAK4 deficiency
MedGen: C1843256 OMIM: 607676 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog
  • AGE/RAGE pathway, organism-specific biosystem (from WikiPathways)
    AGE/RAGE pathway, organism-specific biosystemAdvanced glycation end products (AGEs) are heterogeneous group of non-enzymatic malliard reaction products of aldose sugar with proteins and lipids. Formation of AGEs is an indicator of one of the ma...
  • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
    Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
  • Apoptosis, organism-specific biosystem (from KEGG)
    Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
  • Apoptosis, conserved biosystem (from KEGG)
    Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
  • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • IL-1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-1 Signaling Pathway, organism-specific biosystemThe interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor,...
  • IL1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL1-mediated signaling events, organism-specific biosystem
    IL1-mediated signaling events
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
    Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-1 signaling, organism-specific biosystemInterleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL1R1), the only signaling-capable IL1 receptor. This is a single chain type 1 transmembrane protein comprising an extracellular ligand bindi...
  • Leishmaniasis, organism-specific biosystem (from KEGG)
    Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
  • Leishmaniasis, conserved biosystem (from KEGG)
    Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
    MyD88 cascade initiated on plasma membrane, organism-specific biosystemMammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of...
  • MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
    MyD88 dependent cascade initiated on endosome, organism-specific biosystemUpon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I ...
  • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
    MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
  • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
    NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Pertussis, organism-specific biosystem (from KEGG)
    Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
  • Pertussis, conserved biosystem (from KEGG)
    Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
  • Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Regulation of toll-like receptor signaling pathway, organism-specific biosystem
    Regulation of toll-like receptor signaling pathway
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling, organism-specific biosystem (from REACTOME)
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling, organism-specific biosystemIn plasmacytoid dendritic cell induction of type I IFNs critically depends on IFN regulatory factor 7 in TLR7 and 9 signaling (Honda et al 2005). IRF-7, but not IRF3, interacts with MyD88, TRAF6, and...
  • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemTRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
  • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
  • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
  • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
  • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
  • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
  • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
  • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
  • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
  • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
    Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toxoplasmosis, organism-specific biosystem (from KEGG)
    Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Toxoplasmosis, conserved biosystem (from KEGG)
    Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
interleukin-1 receptor binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity EXP
Inferred from Experiment
more info
 
protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
JNK cascade IEA
Inferred from Electronic Annotation
more info
 
MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
cytokine production IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor 10 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 2 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 4 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 5 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 9 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor TLR1:TLR2 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor TLR6:TLR2 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
endosome membrane TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
interleukin-1 receptor-associated kinase 4
Names
interleukin-1 receptor-associated kinase 4
renal carcinoma antigen NY-REN-64
NP_001107654.1
NP_001138728.1
NP_001138729.1
NP_001138730.1
NP_057207.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009892.1 

    Range
    5001..35600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_75

mRNA and Protein(s)

  1. NM_001114182.2NP_001107654.1  interleukin-1 receptor-associated kinase 4 isoform a

    See proteins identical to NP_001107654.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC093012, AI126481, AK304583, AY340963
    Consensus CDS
    CCDS8744.1
    UniProtKB/TrEMBL
    B4E359
    UniProtKB/TrEMBL
    Q69FE3
    UniProtKB/Swiss-Prot
    Q9NWZ3
    Conserved Domains (3) summary
    cd00180
    Location:193380
    PKc; Catalytic domain of Protein Kinases
    smart00219
    Location:189454
    TyrKc; Tyrosine kinase, catalytic domain
    cd08793
    Location:9106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
  2. NM_001145256.1NP_001138728.1  interleukin-1 receptor-associated kinase 4 isoform b

    See proteins identical to NP_001138728.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and uses a downstream start codon, compared to variant 1. The resulting isoform (b), also known as the short form, has a shorter N-terminus, compared to isoform a. Variants 3, 4, and 5 all encode the same isoform.
    Source sequence(s)
    AC093012, AI126481, AK304583, AY340965
    Consensus CDS
    CCDS44862.1
    UniProtKB/TrEMBL
    B4E359
    UniProtKB/Swiss-Prot
    Q9NWZ3
    Conserved Domains (2) summary
    cd00180
    Location:69256
    PKc; Catalytic domain of Protein Kinases
    smart00219
    Location:65330
    TyrKc; Tyrosine kinase, catalytic domain
  3. NM_001145257.1NP_001138729.1  interleukin-1 receptor-associated kinase 4 isoform b

    See proteins identical to NP_001138729.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons and uses a downstream start codon, compared to variant 1. The resulting isoform (b), also known as the short form, has a shorter N-terminus, compared to isoform a. Variants 3, 4, and 5 all encode the same isoform.
    Source sequence(s)
    AC093012, AI126481, AK299944, AK304583
    Consensus CDS
    CCDS44862.1
    UniProtKB/TrEMBL
    B4E359
    UniProtKB/Swiss-Prot
    Q9NWZ3
    Related
    ENSP00000390327, ENST00000431837
    Conserved Domains (2) summary
    cd00180
    Location:69256
    PKc; Catalytic domain of Protein Kinases
    smart00219
    Location:65330
    TyrKc; Tyrosine kinase, catalytic domain
  4. NM_001145258.1NP_001138730.1  interleukin-1 receptor-associated kinase 4 isoform b

    See proteins identical to NP_001138730.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks three alternate exons and uses a downstream start codon, compared to variant 1. The resulting isoform (b), also known as the short form, has a shorter N-terminus, compared to isoform a. Variants 3, 4, and 5 all encode the same isoform.
    Source sequence(s)
    AC093012, AI126481, AK304583
    Consensus CDS
    CCDS44862.1
    UniProtKB/TrEMBL
    B4E359
    UniProtKB/Swiss-Prot
    Q9NWZ3
    Conserved Domains (2) summary
    cd00180
    Location:69256
    PKc; Catalytic domain of Protein Kinases
    smart00219
    Location:65330
    TyrKc; Tyrosine kinase, catalytic domain
  5. NM_016123.3NP_057207.2  interleukin-1 receptor-associated kinase 4 isoform a

    See proteins identical to NP_057207.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC093012, AI126481, AK304583, AK314288, BC013316
    Consensus CDS
    CCDS8744.1
    UniProtKB/TrEMBL
    B2RAP9
    UniProtKB/TrEMBL
    B4E359
    UniProtKB/TrEMBL
    Q69FE3
    UniProtKB/Swiss-Prot
    Q9NWZ3
    Conserved Domains (3) summary
    cd00180
    Location:193380
    PKc; Catalytic domain of Protein Kinases
    smart00219
    Location:189454
    TyrKc; Tyrosine kinase, catalytic domain
    cd08793
    Location:9106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 

    Range
    43758944..43789543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268947.2XP_005269004.1  

    See proteins identical to XP_005269004.1

    UniProtKB/Swiss-Prot
    Q9NWZ3
    Conserved Domains (2) summary
    cd00180
    Location:69256
    PKc; Catalytic domain of Protein Kinases
    smart00219
    Location:65330
    TyrKc; Tyrosine kinase, catalytic domain
  2. XM_006719441.1XP_006719504.1  

    See proteins identical to XP_006719504.1

    Conserved Domains (1) summary
    cd00180
    Location:14177
    PKc; Catalytic domain of Protein Kinases
  3. XM_006719439.1XP_006719502.1  

    See proteins identical to XP_006719502.1

    UniProtKB/Swiss-Prot
    Q9NWZ3
    Conserved Domains (2) summary
    cd00180
    Location:69256
    PKc; Catalytic domain of Protein Kinases
    smart00219
    Location:65330
    TyrKc; Tyrosine kinase, catalytic domain
  4. XM_005268948.1XP_005269005.1  

    See proteins identical to XP_005269005.1

    UniProtKB/Swiss-Prot
    Q9NWZ3
    Conserved Domains (2) summary
    cd00180
    Location:69256
    PKc; Catalytic domain of Protein Kinases
    smart00219
    Location:65330
    TyrKc; Tyrosine kinase, catalytic domain
  5. XM_006719440.1XP_006719503.1  

    See proteins identical to XP_006719503.1

    Conserved Domains (1) summary
    cd00180
    Location:14177
    PKc; Catalytic domain of Protein Kinases
  6. XM_006719442.1XP_006719505.1  

    See proteins identical to XP_006719505.1

    Conserved Domains (1) summary
    cd00180
    Location:14177
    PKc; Catalytic domain of Protein Kinases
  7. XM_005268949.1XP_005269006.1  

    See proteins identical to XP_005269006.1

    UniProtKB/Swiss-Prot
    Q9NWZ3
    Conserved Domains (2) summary
    cd00180
    Location:69256
    PKc; Catalytic domain of Protein Kinases
    smart00219
    Location:65330
    TyrKc; Tyrosine kinase, catalytic domain
  8. XM_006719443.1XP_006719506.1  

    See proteins identical to XP_006719506.1

    Conserved Domains (1) summary
    cd00180
    Location:14177
    PKc; Catalytic domain of Protein Kinases
  9. XM_005268943.2XP_005269000.1  

    See proteins identical to XP_005269000.1

    UniProtKB/TrEMBL
    Q69FE3
    UniProtKB/Swiss-Prot
    Q9NWZ3
    Conserved Domains (3) summary
    cd00180
    Location:193380
    PKc; Catalytic domain of Protein Kinases
    smart00219
    Location:189454
    TyrKc; Tyrosine kinase, catalytic domain
    cd08793
    Location:9106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
  10. XM_006719438.1XP_006719501.1  

    See proteins identical to XP_006719501.1

    UniProtKB/TrEMBL
    Q69FE3
    UniProtKB/Swiss-Prot
    Q9NWZ3
    Conserved Domains (3) summary
    cd00180
    Location:193380
    PKc; Catalytic domain of Protein Kinases
    smart00219
    Location:189454
    TyrKc; Tyrosine kinase, catalytic domain
    cd08793
    Location:9106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
  11. XM_005268945.2XP_005269002.1  

    See proteins identical to XP_005269002.1

    UniProtKB/TrEMBL
    Q69FE3
    UniProtKB/Swiss-Prot
    Q9NWZ3
    Conserved Domains (3) summary
    cd00180
    Location:193380
    PKc; Catalytic domain of Protein Kinases
    smart00219
    Location:189454
    TyrKc; Tyrosine kinase, catalytic domain
    cd08793
    Location:9106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
  12. XM_005268944.2XP_005269001.1  

    See proteins identical to XP_005269001.1

    UniProtKB/TrEMBL
    Q69FE3
    UniProtKB/Swiss-Prot
    Q9NWZ3
    Conserved Domains (3) summary
    cd00180
    Location:193380
    PKc; Catalytic domain of Protein Kinases
    smart00219
    Location:189454
    TyrKc; Tyrosine kinase, catalytic domain
    cd08793
    Location:9106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
  13. XM_005268946.2XP_005269003.1  

    See proteins identical to XP_005269003.1

    UniProtKB/TrEMBL
    Q69FE3
    UniProtKB/Swiss-Prot
    Q9NWZ3
    Conserved Domains (3) summary
    cd00180
    Location:193380
    PKc; Catalytic domain of Protein Kinases
    smart00219
    Location:189454
    TyrKc; Tyrosine kinase, catalytic domain
    cd08793
    Location:9106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4

Alternate HuRef

Genomic

  1. AC_000144.1 

    Range
    41181921..41210557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 

    Range
    44117733..44148328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)