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PI15 peptidase inhibitor 15 [ Homo sapiens (human) ]

Gene ID: 51050, updated on 7-Dec-2014
Official Symbol
PI15provided by HGNC
Official Full Name
peptidase inhibitor 15provided by HGNC
Primary source
HGNC:HGNC:8946
See related
Ensembl:ENSG00000137558; HPRD:06150; MIM:607076; Vega:OTTHUMG00000164528
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P24TI; P25TI; CRISP8
Summary
This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008]
See PI15 in Epigenomics, MapViewer
Location:
8q21.11
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 8 NC_000008.11 (74824537..74855029)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (75736772..75767264)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC441355 Neighboring gene poly(rC) binding protein 2 pseudogene 2 Neighboring gene microRNA 2052 Neighboring gene cysteine-rich secretory protein LCCL domain containing 1 Neighboring gene cancer susceptibility candidate 9 (non-protein coding)

NHGRI GWAS Catalog

Description
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
NHGRI GWA Catalog

Markers

Homology

Clone Names

  • DKFZp686F0366

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
peptidase inhibitor 15
Names
peptidase inhibitor 15
PI-15
CRISP-8
sugarCrisp
protease inhibitor 15
25 kDa trypsin inhibitor
cysteine-rich secretory protein 8

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015886.3NP_056970.1  peptidase inhibitor 15 preproprotein

    See proteins identical to NP_056970.1

    Status: REVIEWED

    Source sequence(s)
    AC011632, CR749657, D45027
    Consensus CDS
    CCDS6218.1
    UniProtKB/Swiss-Prot
    O43692
    Related
    ENSP00000260113, OTTHUMP00000226900, ENST00000260113, OTTHUMT00000379115
    Conserved Domains (1) summary
    cd05380
    Location:69212
    SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000008.11 

    Range
    74824537..74855029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716453.1XP_006716516.1  

    See proteins identical to XP_006716516.1

    UniProtKB/Swiss-Prot
    O43692
    Conserved Domains (1) summary
    cd05380
    Location:69212
    SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...
  2. XM_005251255.1XP_005251312.1  

    Conserved Domains (1) summary
    cd05380
    Location:6127
    SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 

    Range
    75788390..75818882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000140.1 

    Range
    71227247..71257719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)