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    ZBTB7B zinc finger and BTB domain containing 7B [ Homo sapiens ]

    Gene ID: 51043, updated on 23-May-2012

    Summary

    Official Symbol
    ZBTB7Bprovided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 7Bprovided by HGNC
    Primary source
    HGNC:18668
    Locus tag
    RP11-307C12.9
    See related
    Ensembl:ENSG00000160685; HPRD:09625; MIM:607646; Vega:OTTHUMG00000037414
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    THPOK; ZFP67; ZBTB15; ZFP-67; c-KROX; hcKROX; ZNF857B; DKFZp686G01254
    Summary
    This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

    Genomic context

    Location :
    1q21.3
    Sequence :
    Chromosome: 1; NC_000001.10 (154975112..154990999)
    See ZBTB7B in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) Neighboring gene lens epithelial protein Neighboring gene DC-STAMP domain containing 2 Neighboring gene DC-STAMP domain containing 1 Neighboring gene uncharacterized LOC100505666

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O15156 O75791 GRAP2    HPRD  PubMed  
    BioGRID:119242 BioGRID:115455 CEBPZ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119242 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity 
    BioGRID:119242 BioGRID:114799 GRAP2    BioGRID  PubMed Two-hybrid 
    BioGRID:119242 BioGRID:116022 HSPH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119242 BioGRID:115770 MYBBP1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119242 BioGRID:115842 PRPF8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119242 BioGRID:111902 RELA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119242 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119242 BioGRID:112553 SP3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119242 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119242 BioGRID:119242 ZBTB7B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119242 BioGRID:116349 ZNF277    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    ectoderm development TAS
    Traceable Author Statement
    more info
    PubMed 
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 7B
    Names
    zinc finger and BTB domain-containing protein 7B
    zinc finger protein 857B
    zinc finger protein Th-POK
    zinc finger protein 67 homolog
    zinc finger and BTB domain containing 15
    T-helper-inducing POZ/Krueppel-like factor
    krueppel-related zinc finger protein cKrox

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252406.2NP_001239335.1  zinc finger and BTB domain-containing protein 7B isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (2).
      Source sequence(s)
      AI270090, AK304762, AL451085, BC012070, CV572166, DA970906, DB241444
      UniProtKB/TrEMBL
      B4E3K5
      UniProtKB/Swiss-Prot
      O15156
      Conserved Domains (2) summary
      pfam13465
      Location:397419
      Blast Score: 102
      zf-H2C2_2; Zinc-finger double domain
      cl02518
      Location:58176
      Blast Score: 269
      BTB; BTB/POZ domain
    2. NM_001256455.1NP_001243384.1  zinc finger and BTB domain-containing protein 7B isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two alternate exons in the 5' UTR and 5' coding region, and uses a downstream in-frame start codon, comapred to variant 3. The encoded isoform (1) is shorter at the N-terminus, compared to isoform 2.
      Source sequence(s)
      AI270090, AL451085, BC012070, CV572166, DA970906
      Consensus CDS
      CCDS1081.1
      UniProtKB/Swiss-Prot
      O15156
      Conserved Domains (2) summary
      pfam13465
      Location:363385
      Blast Score: 100
      zf-H2C2_2; Zinc-finger double domain
      cl02518
      Location:24142
      Blast Score: 262
      BTB; BTB/POZ domain

    RNA

    1. NR_045515.1 RNA Sequence

      Description
      Transcript Variant: This variant (4) contains alternate 5' exon structure, compared to variant 3. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest in-frame ORF. Translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF007833, AI270090, AK127884, AL451085, AW663133, BC012070, BX114870, CR749303, DA970906
    2. NR_046206.1 RNA Sequence

      Description
      Transcript Variant: This variant (2) contains alternate exon structure in the 5' and central regions, compared to variant 3. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest in-frame ORF. Translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI270090, AK291619, AL451085, DA970906
    3. NR_049765.1 RNA Sequence

      Description
      Transcript Variant: This variant (1) lacks an alternate segment and two alternate exons in the 5' region, compared to variant 3. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest in-frame ORF. Translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI270090, AL451085, BC012070, DA970906

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      154975112..154990999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      126337222..126352991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL451085.20 CAI13266.1
    genomic CH471121.2 EAW53149.1
      EAW53150.1
      EAW53151.1
    mRNA AF007833.1 AAC51847.1
    mRNA AI270090.1 None
    mRNA AK127884.1 None
    mRNA AK291619.1 BAF84308.1
    mRNA AK304762.1 BAG65517.1
    mRNA AW663133.1 None
    mRNA BC012070.1 AAH12070.1
    mRNA BC128176.1 None
    mRNA BF510901.1 None
    mRNA BM801567.1 None
    mRNA BX114870.1 None
    mRNA CK820289.1 None
    mRNA CR749303.1 CAH18158.1
    mRNA CV572166.1 None
    mRNA DA970906.1 None
    mRNA DB241444.1 None
    other-genetic EU446494.1 ABZ92023.1
    other-genetic EU832462.1 ACE87634.1
    other-genetic EU832510.1 ACE87682.1
    other-genetic EU832516.1 ACE87688.1
    other-genetic EU832544.1 ACE86946.1
    other-genetic EU832591.1 ACE86993.1
    other-genetic EU832597.1 ACE86999.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15156.2 GenPept UniProtKB/Swiss-Prot:O15156

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