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    UBXN1 UBX domain protein 1 [ Homo sapiens ]

    Gene ID: 51035, updated on 11-May-2012

    Summary

    Official Symbol
    UBXN1provided by HGNC
    Official Full Name
    UBX domain protein 1provided by HGNC
    Primary source
    HGNC:18402
    See related
    Ensembl:ENSG00000162191; HPRD:11266; Vega:OTTHUMG00000167580
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    2B28; SAKS1; UBXD10

    Genomic context

    Location :
    11q12.3
    Sequence :
    Chromosome: 11; NC_000011.9 (62443972..62446527, complement)
    See UBXN1 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 48 Neighboring gene methyltransferase like 12 Neighboring gene small nucleolar RNA, H/ACA box 57 Neighboring gene chromosome 11 open reading frame 83 Neighboring gene HNRNPUL2-BSCL2 readthrough Neighboring gene LRRN4 C-terminal like Neighboring gene Berardinelli-Seip congenital lipodystrophy 2 (seipin) Neighboring gene guanine nucleotide binding protein (G protein), gamma 3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    SAPK substrate protein 1 Q04771 ACVR1    HPRD  PubMed  
    SAPK substrate protein 1 O00238 BMPR1B    HPRD  PubMed  
    SAPK substrate protein 1 Q15797 SMAD1    HPRD  PubMed  
    SAPK substrate protein 1 Q9HCE7 SMURF1    HPRD  PubMed  
    SAPK substrate protein 1 P36897 TGFBR1    HPRD  PubMed  
    BioGRID:119239 BioGRID:106751 ALPP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:106764 AMFR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:120845 ASF1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:118855 BABAM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:107056 BARD1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:119239 BioGRID:106827 BIRC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:119239 BioGRID:120778 BTBD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:107454 CDK4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:119239 BioGRID:114031 CUL2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:119239 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:119239 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:109338 HIF1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119239 BioGRID:115385 HUWE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:123873 KBTBD7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:121890 KLHL12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:124308 KLHL22    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:120798 NPLOC4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:119239 BioGRID:115200 PJA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:119319 RLIM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:119239 BioGRID:113185 UBE3A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:115566 UBE4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:128238 UBR1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:119239 BioGRID:116896 UBR2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:116934 UBR4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:119501 UBR5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:113200 UFD1L    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119239 BioGRID:124189 USP32    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:113258 VCP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:119239 BioGRID:123125 VCPIP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119239 BioGRID:124884 WDR20    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    • Homologs of the UBXN1 gene: The UBXN1 gene is conserved in chimpanzee, , dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, , and N.crassa.
    • Map Viewer (Mouse, Rat)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    K6-linked polyubiquitin binding IDA
    Inferred from Direct Assay
    more info
     
    polyubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
     
    ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Cdc48p-Npl4p-Ufd1p AAA ATPase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with proteasome complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    UBX domain-containing protein 1
    Names
    UBX domain-containing protein 1
    SAPK substrate protein 1
    UBA/UBX 33.3 kDa protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015853.3NP_056937.2  UBX domain-containing protein 1

      Status: PROVISIONAL

      Source sequence(s)
      BC001372
      Consensus CDS
      CCDS8029.1
      UniProtKB/Swiss-Prot
      Q04323
      Related
      ENSP00000294119, OTTHUMP00000236216, ENST00000294119, OTTHUMT00000395151
      Conserved Domains (2) summary
      cd00194
      Location:541
      Blast Score: 104
      UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
      cd01772
      Location:210283
      Blast Score: 281
      SAKS1_UBX; SAKS1-like UBX domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      62443972..62446527, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      58772838..58775393, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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