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SLC35C2 solute carrier family 35 member C2 [ Homo sapiens (human) ]

Gene ID: 51006, updated on 26-May-2016
Official Symbol
SLC35C2provided by HGNC
Official Full Name
solute carrier family 35 member C2provided by HGNC
Primary source
HGNC:HGNC:17117
See related
Ensembl:ENSG00000080189 HPRD:15371; Vega:OTTHUMG00000033050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-15; OVCOV1; C20orf5; BA394O2.1
Summary
This gene encodes a member of the triose-phosphate transporter protein family. This gene is regulated by oxygen tension, is induced in hypoxic trophoblast cells, and is overexpressed in ovarian cancer. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]
Orthologs
Location:
20q13.12
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 20 NC_000020.11 (46349528..46364458, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44978167..44993097, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene CD40 molecule Neighboring gene uncharacterized LOC105376977 Neighboring gene cadherin 22 Neighboring gene uncharacterized LOC105372634 Neighboring gene engulfment and cell motility 2 Neighboring gene uncharacterized LOC105372633

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ37039, FLJ46434, MGC20633, MGC32079, MGC39183

Gene Ontology Provided by GOA

Process Evidence Code Pubs
UDP-glucose transport IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
protein O-linked fucosylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cis-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
solute carrier family 35 member C2
Names
ovarian cancer-overexpressed gene 1 protein
solute carrier family 35 (GDP-fucose transporter), member C2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281457.1NP_001268386.1  solute carrier family 35 member C2 isoform c

    See identical proteins and their annotated locations for NP_001268386.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    BC021138, BM666377, DA820126, DB246755
    UniProtKB/Swiss-Prot
    Q9NQQ7
    Conserved Domains (1) summary
    pfam03151
    Location:51199
    TPT; Triose-phosphate Transporter family
  2. NM_001281458.1NP_001268387.1  solute carrier family 35 member C2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) has a longer and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK301022, BC021138, BM666377, DA820126
    Consensus CDS
    CCDS63292.1
    UniProtKB/Swiss-Prot
    Q9NQQ7
    Related
    ENSP00000318960, ENST00000317734
    Conserved Domains (2) summary
    TIGR00817
    Location:45347
    tpt; Tpt phosphate/phosphoenolpyruvate translocator
    pfam03151
    Location:194342
    TPT; Triose-phosphate Transporter family
  3. NM_001281459.1NP_001268388.1  solute carrier family 35 member C2 isoform e

    See identical proteins and their annotated locations for NP_001268388.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
    Source sequence(s)
    BC021138, BI831689, BM666377, DA820126
    UniProtKB/Swiss-Prot
    Q9NQQ7
    UniProtKB/TrEMBL
    B7Z6R4
    Conserved Domains (1) summary
    pfam03151
    Location:30178
    TPT; Triose-phosphate Transporter family
  4. NM_001281460.1NP_001268389.1  solute carrier family 35 member C2 isoform a

    See identical proteins and their annotated locations for NP_001268389.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 7 encode the same isoform (a).
    Source sequence(s)
    BC025277, BM666377, DA820126, DB023133
    Consensus CDS
    CCDS13396.1
    UniProtKB/Swiss-Prot
    Q9NQQ7
    Related
    ENSP00000361301, OTTHUMP00000031692, ENST00000372227, OTTHUMT00000080363
    Conserved Domains (2) summary
    TIGR00817
    Location:16318
    tpt; Tpt phosphate/phosphoenolpyruvate translocator
    pfam03151
    Location:165313
    TPT; Triose-phosphate Transporter family
  5. NM_015945.11NP_057029.8  solute carrier family 35 member C2 isoform a

    See identical proteins and their annotated locations for NP_057029.8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 7 encode the same isoform (a).
    Source sequence(s)
    AK222928, BC014191, BM666377, DA820126
    Consensus CDS
    CCDS13396.1
    UniProtKB/Swiss-Prot
    Q9NQQ7
    Related
    ENSP00000361304, OTTHUMP00000031696, ENST00000372230, OTTHUMT00000080373
    Conserved Domains (2) summary
    TIGR00817
    Location:16318
    tpt; Tpt phosphate/phosphoenolpyruvate translocator
    pfam03151
    Location:165313
    TPT; Triose-phosphate Transporter family
  6. NM_173073.3NP_775096.1  solute carrier family 35 member C2 isoform b

    See identical proteins and their annotated locations for NP_775096.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    BC014191, BM666377, DA820126
    Consensus CDS
    CCDS13397.1
    UniProtKB/Swiss-Prot
    Q9NQQ7
    Related
    ENSP00000439974, OTTHUMP00000031690, ENST00000543605, OTTHUMT00000080361
    Conserved Domains (2) summary
    TIGR00817
    Location:16297
    tpt; Tpt phosphate/phosphoenolpyruvate translocator
    pfam03151
    Location:144292
    TPT; Triose-phosphate Transporter family
  7. NM_173179.3NP_775271.1  solute carrier family 35 member C2 isoform a

    See identical proteins and their annotated locations for NP_775271.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1, 2, and 7 encode the same isoform.
    Source sequence(s)
    BC021138, BM666377, DA820126
    Consensus CDS
    CCDS13396.1
    UniProtKB/Swiss-Prot
    Q9NQQ7
    Related
    ENSP00000243896, OTTHUMP00000031691, ENST00000243896, OTTHUMT00000080362
    Conserved Domains (2) summary
    TIGR00817
    Location:16318
    tpt; Tpt phosphate/phosphoenolpyruvate translocator
    pfam03151
    Location:165313
    TPT; Triose-phosphate Transporter family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p2 Primary Assembly

    Range
    46349528..46364458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528835.1XP_011527137.1  

    Conserved Domains (1) summary
    pfam03151
    Location:203275
    TPT; Triose-phosphate Transporter family
  2. XM_011528834.1XP_011527136.1  

    Conserved Domains (1) summary
    pfam03151
    Location:240312
    TPT; Triose-phosphate Transporter family
  3. XM_011528836.1XP_011527138.1  

    See identical proteins and their annotated locations for XP_011527138.1

    Conserved Domains (1) summary
    pfam03151
    Location:51199
    TPT; Triose-phosphate Transporter family
  4. XM_011528832.1XP_011527134.1  

    See identical proteins and their annotated locations for XP_011527134.1

    UniProtKB/Swiss-Prot
    Q9NQQ7
    Conserved Domains (2) summary
    TIGR00817
    Location:16318
    tpt; Tpt phosphate/phosphoenolpyruvate translocator
    pfam03151
    Location:165313
    TPT; Triose-phosphate Transporter family
  5. XM_011528833.1XP_011527135.1  

    See identical proteins and their annotated locations for XP_011527135.1

    UniProtKB/Swiss-Prot
    Q9NQQ7
    Conserved Domains (2) summary
    TIGR00817
    Location:16318
    tpt; Tpt phosphate/phosphoenolpyruvate translocator
    pfam03151
    Location:165313
    TPT; Triose-phosphate Transporter family
  6. XM_011528837.1XP_011527139.1  

    See identical proteins and their annotated locations for XP_011527139.1

    Conserved Domains (1) summary
    pfam03151
    Location:51199
    TPT; Triose-phosphate Transporter family
  7. XM_011528831.1XP_011527133.1  

    See identical proteins and their annotated locations for XP_011527133.1

    UniProtKB/Swiss-Prot
    Q9NQQ7
    Conserved Domains (2) summary
    TIGR00817
    Location:16318
    tpt; Tpt phosphate/phosphoenolpyruvate translocator
    pfam03151
    Location:165313
    TPT; Triose-phosphate Transporter family
  8. XM_011528838.1XP_011527140.1  

    Conserved Domains (1) summary
    pfam03151
    Location:13161
    TPT; Triose-phosphate Transporter family

RNA

  1. XR_936543.1 RNA Sequence

  2. XR_936541.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    44880806..44895718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)