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    MED31 mediator complex subunit 31 [ Homo sapiens ]

    Gene ID: 51003, updated on 11-May-2012
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    Summary

    Official Symbol
    MED31provided by HGNC
    Official Full Name
    mediator complex subunit 31provided by HGNC
    Primary source
    HGNC:24260
    Locus tag
    CGI-125
    See related
    Ensembl:ENSG00000108590; HPRD:14382; Vega:OTTHUMG00000102051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Soh1; CGI-125; 3110004H13Rik; FLJ27436; FLJ36714
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    Genomic context

    Location :
    17p13.1
    Sequence :
    Chromosome: 17; NC_000017.10 (6546633..6554954, complement)
    See MED31 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene PITPNM family member 3 Neighboring gene KIAA0753 Neighboring gene thioredoxin domain containing 17 Neighboring gene chromosome 17 open reading frame 100 Neighboring gene microRNA 4520a Neighboring gene microRNA 4520b

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    2. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. Krebs AR, et al. EMBO Rep, 2010 Jul. PMID 20508642.
    3. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142.
    4. Streamlined analysis schema for high-throughput identification of endogenous protein complexes. Malovannaya A, et al. Proc Natl Acad Sci U S A, 2010 Feb 9. PMID 20133760.
    5. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9Y3C7 Q08117 AES    HPRD  PubMed  
    Q9Y3C7 O95994 AGR2    HPRD  PubMed  
    Q9Y3C7 Q9H1I8 ASCC2    HPRD  PubMed  
    Q9Y3C7 Chromosome 2 open reading frame 44 C2orf44    HPRD  PubMed  
    Q9Y3C7 O00305 CACNB4    HPRD  PubMed  
    Q9Y3C7 Q99832 CCT7    HPRD  PubMed  
    Q9Y3C7 P16870 CPE    HPRD  PubMed  
    Q9Y3C7 Q05193 DNM1    HPRD  PubMed  
    Q9Y3C7 P26641 EEF1G    HPRD  PubMed  
    Q9Y3C7 P11161 EGR2    HPRD  PubMed  
    Q9Y3C7 Q9Y6I3 EPN1    HPRD  PubMed  
    Q9Y3C7 P84090 ERH    HPRD  PubMed  
    Q9Y3C7 Q9BTY7 FAM203A    HPRD  PubMed  
    Q9Y3C7 O95257 GADD45G    HPRD  PubMed  
    Q9Y3C7 Q03013 GSTM4    HPRD  PubMed  
    Q9Y3C7 P30519 HMOX2    HPRD  PubMed  
    Q9Y3C7 Q9BUJ2 HNRNPUL1    HPRD  PubMed  
    Q9Y3C7 P04792 HSPB1    HPRD  PubMed  
    Q9Y3C7 Q12988 HSPB3    HPRD  PubMed  
    Q9Y3C7 P42858 HTT    HPRD  PubMed  
    Q9Y3C7 Q16363 LAMA4    HPRD  PubMed  
    Q9Y3C7 O95372 LYPLA2    HPRD  PubMed  
    Q9Y3C7 O15525 MAFG    HPRD  PubMed  
    Q9Y3C7 MED18 MED18    HPRD  PubMed  
    Q9Y3C7 Mediator of RNA polymerase II transcription subunit 19 MED19    HPRD  PubMed  
    Q9Y3C7 Q96G25 MED8    HPRD  PubMed  
    Q9Y3C7 MED9 MED9    HPRD  PubMed  
    Q9Y3C7 Q9Y3A3 MOB4    HPRD  PubMed  
    Q9Y3C7 Q13469 NFATC2    HPRD  PubMed  
    Q9Y3C7 Q96SN7 ORAI2    HPRD  PubMed  
    Q9Y3C7 Q13310 PABPC4    HPRD  PubMed  
    Q9Y3C7 Q15102 PAFAH1B3    HPRD  PubMed  
    Q9Y3C7 O60925 PFDN1    HPRD  PubMed  
    Q9Y3C7 Q6P1K2 PMF1    HPRD  PubMed  
    Q9Y3C7 O60828 PQBP1    HPRD  PubMed  
    Q9Y3C7 Q99873 PRMT1    HPRD  PubMed  
    Q9Y3C7 O00231 PSMD11    HPRD  PubMed  
    Q9Y3C7 P57735 RAB25    HPRD  PubMed  
    Q9Y3C7 Q86U06 RBM23    HPRD  PubMed  
    Q9Y3C7 P40937 RFC5    HPRD  PubMed  
    Q9Y3C7 P15927 RPA2    HPRD  PubMed  
    Q9Y3C7 P21673 SAT1    HPRD  PubMed  
    Q9Y3C7 Q13228 SELENBP1    HPRD  PubMed  
    Q9Y3C7 P50453 SERPINB9    HPRD  PubMed  
    Q9Y3C7 Q15583 TGIF1    HPRD  PubMed  
    Q9Y3C7 Q9GZM7 TINAGL1    HPRD  PubMed  
    Q9Y3C7 P63146 UBE2B    HPRD  PubMed  
    Q9Y3C7 Q96K62 ZBTB45    HPRD  PubMed  
    Q9Y3C7 O43261     HPRD  PubMed  
    BioGRID:119211 BioGRID:106675 AES    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:115802 AGR2    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:106807 ANXA7    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:123921 ASCC2    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:123217 C2orf44    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:107239 CACNB4    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:115825 CCT7    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:107458 CDK8    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:119211 BioGRID:107460 CDKN1A    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:107755 CPE    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:115143 DAZAP2    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:115589 DLEU1    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:108099 DNM1    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:108257 EEF1G    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:108279 EGR2    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:118965 EPN1    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:108390 ERH    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:122742 FAM118B    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:119398 FAM203A    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:116117 GADD45G    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119211 BioGRID:109203 GSTM4    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:109406 HMOX2    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:116281 HNRNPUL1    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:109547 HSPB1    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:114470 HSPB3    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:109314 HTT    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:119211 BioGRID:110104 LAMA4    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:116444 LYPLA2    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:110272 MAFG    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:111465 MED1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119211 BioGRID:123974 MED10    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:119211 BioGRID:115293 MED12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119211 BioGRID:120156 MED18    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119211 BioGRID:128553 MED19    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:119211 BioGRID:114831 MED26    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119211 BioGRID:123219 MED28    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119211 BioGRID:120734 MED29    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:119211 BioGRID:114833 MED7    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:120403 MED9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119211 BioGRID:117369 MOB4    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:110846 NFATC2    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:109407 NR4A1    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:123192 ORAI2    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:111087 PAFAH1B3    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:111223 PFDN1    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:116405 PMF1    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:115393 PQBP1    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:109512 PRMT1    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:111689 PSMD11    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:114834 QKI    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119211 BioGRID:120450 RBM23    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:111917 RFC5    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:112038 RPA2    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:112210 SAT1    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:114472 SELENBP1    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:111290 SERPINB9    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:112490 SMN1    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:203575 Supt5h    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:112734 TADA2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119211 BioGRID:112908 TGIF1    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:122078 TINAGL1    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:112938 TK1    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:113168 UBE2B    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:124322 ZBTB45    BioGRID  PubMed Two-hybrid 
    BioGRID:119211 BioGRID:129825 ZSCAN1    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
      Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • PPARA Activates Gene Expression, organism-specific biosystem (from REACTOME)
      PPARA Activates Gene Expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
    • Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
      Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
    • Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA polymerase II transcription cofactor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    protein complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 31
    Names
    mediator of RNA polymerase II transcription subunit 31
    hSOH1
    mediator complex subunit SOH1
    mediator of RNA polymerase II transcription, subunit 31 homolog
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016060.2 → NP_057144.1  mediator of RNA polymerase II transcription subunit 31

      Status: VALIDATED

      Source sequence(s)
      AC004706, AF151883, AK130946
      Consensus CDS
      CCDS11078.1
      UniProtKB/Swiss-Prot
      Q9Y3C7
      Related
      ENSP00000225728, OTTHUMP00000128225, ENST00000225728, OTTHUMT00000219852
      Conserved Domains (1) summary
      cl02121
      Location:13 – 114
      Blast Score: 434
      Med31; SOH1

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      6546633..6554954, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      6441917..6450238, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC004706.1 (19020..27312) None
    genomic CH471108.2 EAW90301.1
    mRNA AF151883.1 AAD34120.1
    mRNA AK094033.1 None
    mRNA AK130946.1 None
    mRNA AK311875.1 BAG34816.1
    mRNA BC012539.1 AAH12539.1
    other-genetic JF432553.1 ADZ15770.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y3C7.1 GenPept UniProtKB/Swiss-Prot:Q9Y3C7
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

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