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MED31 mediator complex subunit 31 [ Homo sapiens (human) ]

Gene ID: 51003, updated on 6-Jul-2014
Official Symbol
MED31provided by HGNC
Official Full Name
mediator complex subunit 31provided by HGNC
Primary source
HGNC:24260
Locus tag
CGI-125
See related
Ensembl:ENSG00000108590; HPRD:14382; Vega:OTTHUMG00000102051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Soh1; CGI-125; 3110004H13Rik
See MED31 in Epigenomics, MapViewer
Location:
17p13.1
Exon count :
4
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (6643313..6651799, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6546633..6555191, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene PITPNM family member 3 Neighboring gene KIAA0753 Neighboring gene collagen alpha-1(I) chain-like Neighboring gene thioredoxin domain containing 17 Neighboring gene chromosome 17 open reading frame 100 Neighboring gene microRNA 4520-1 Neighboring gene microRNA 4520-2 Neighboring gene arachidonate 15-lipoxygenase pseudogene 1

Replication interactions

Interaction Pubs
Knockdown of mediator complex subunit 31 (MED31) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat, p14 tat Knockdown of MED31 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
    PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
  • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
  • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II transcription cofactor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
gene expression TAS
Traceable Author Statement
more info
 
limb development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
protein complex assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mediator complex IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
Preferred Names
mediator of RNA polymerase II transcription subunit 31
Names
mediator of RNA polymerase II transcription subunit 31
hSOH1
mediator complex subunit SOH1
mediator of RNA polymerase II transcription, subunit 31 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016060.2NP_057144.1  mediator of RNA polymerase II transcription subunit 31

    See proteins identical to NP_057144.1

    Status: VALIDATED

    Source sequence(s)
    AC004706, AF151883, AK130946
    Consensus CDS
    CCDS11078.1
    UniProtKB/Swiss-Prot
    Q9Y3C7
    Related
    ENSP00000225728, OTTHUMP00000128225, ENST00000225728, OTTHUMT00000219852
    Conserved Domains (1) summary
    pfam05669
    Location:13114
    Blast Score: 436
    Med31; SOH1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    6643313..6651799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256671.2XP_005256728.1  

    Conserved Domains (2) summary
    cl02121
    Location:98120
    Blast Score: 134
    Med31; SOH1
    cl19202
    Location:76115
    Blast Score: 76
    Bac_GDH; Bacterial NAD-glutamate dehydrogenase

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    6441917..6450238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    6556928..6565240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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