Coil coilin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Coilprovided by RGD
Official Full Name: coilinprovided by RGD
Primary source: RGD:62031
See related: Ensembl:ENSRNOG00000000244 AllianceGenome:RGD:62031
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein C-terminus binding activity. Predicted to be involved in spliceosomal snRNP assembly. Predicted to be located in female germ cell nucleus; fibrillar center; and nuclear body. Predicted to be active in Cajal body. Orthologous to human COIL (coilin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 231.0), Brain (RPKM 57.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (74286279..74307597)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (73789077..73810378)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (76320676..76336169)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables U1 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables U2 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables disulfide oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in spliceosomal snRNP assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Cajal body	IBA Inferred from Biological aspect of Ancestor more info
located_in Cajal body	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in female germ cell nucleus	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: coilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017360.2 → NP_059056.2 coilin

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I5ZUZ7, A6HHZ5

Related

ENSRNOP00000082470.1, ENSRNOT00000110927.1

Conserved Domains (1) summary

pfam15862
Location:7 → 138

Coilin_N; Coilin N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

74286279..74307597

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086664.2 → XP_038942592.1 coilin isoform X1

UniProtKB/TrEMBL

A0A8I5ZUZ7, A6HHZ5, E9PTJ1

Related

ENSRNOP00000030534.6

Conserved Domains (1) summary

pfam15862
Location:10 → 141

Coilin_N; Coilin N-terminus