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CDON cell adhesion associated, oncogene regulated [ Homo sapiens (human) ]

Gene ID: 50937, updated on 26-May-2016
Official Symbol
CDONprovided by HGNC
Official Full Name
cell adhesion associated, oncogene regulatedprovided by HGNC
Primary source
HGNC:HGNC:17104
See related
Ensembl:ENSG00000064309 HPRD:16372; MIM:608707; Vega:OTTHUMG00000165862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDO; CDON1; HPE11; ORCAM
Summary
This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]
Orthologs
Location:
11q24.2
Exon count:
23
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (125956818..126063292, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (125826713..125933187, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369554 Neighboring gene uncharacterized LOC105369555 Neighboring gene V-set and immunoglobulin domain-containing protein 10-like Neighboring gene nucleosome assembly protein 1 like 1 pseudogene 1 Neighboring gene uncharacterized LOC105369556

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Holoprosencephaly 11
MedGen: C3280215 OMIM: 614226 GeneReviews: Not available
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NHGRI GWAS Catalog

Description
Genetic variants associated with breast size also influence breast cancer risk.
NHGRI GWA Catalog
Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene.
NHGRI GWA Catalog
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.
NHGRI GWA Catalog
  • Activation of SMO, organism-specific biosystem (from REACTOME)
    Activation of SMO, organism-specific biosystemActivation of the transmembrane protein SMO in response to Hh stimulation is a major control point in the Hh signaling pathway (reviewed in Ayers and Therond, 2010; Jiang and Hui, 2008). In the absen...
  • CDO in myogenesis, organism-specific biosystem (from REACTOME)
    CDO in myogenesis, organism-specific biosystemCDO/Cdon (cell-adhesion-molecule-related/downregulated by oncogenes) is a type I transmembrane multifunctional co-receptor consisting of five immunoglobulin and three fibronectin type III (FNIII) rep...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Hedgehog 'on' state, organism-specific biosystem (from REACTOME)
    Hedgehog 'on' state, organism-specific biosystemHedgehog is a secreted morphogen that has evolutionarily conserved roles in body organization by regulating the activity of the Ci/Gli transcription factor family. In Drosophila in the absence of Hh ...
  • Hedgehog signaling pathway, organism-specific biosystem (from KEGG)
    Hedgehog signaling pathway, organism-specific biosystemThe Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and or...
  • Hedgehog signaling pathway, conserved biosystem (from KEGG)
    Hedgehog signaling pathway, conserved biosystemThe Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and or...
  • Ligand-receptor interactions, organism-specific biosystem (from REACTOME)
    Ligand-receptor interactions, organism-specific biosystemRepression of Hh signaling in the absence of ligand depends on the transmembrane receptor protein Patched (PTCH), which inhibits Smoothened (SMO) activity by an unknown mechanism. This promotes the p...
  • Myogenesis, organism-specific biosystem (from REACTOME)
    Myogenesis, organism-specific biosystemMyogenesis, the formation of muscle tissue, is a complex process involving steps of cell proliferation mediated by growth factor signaling, cell differentiation, reorganization of cells to form myotu...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Hedgehog, organism-specific biosystem (from REACTOME)
    Signaling by Hedgehog, organism-specific biosystemHedgehog (Hh) is a secreted morphogen that regulates developmental processes in vertebrates including limb bud formation, neural tube patterning, cell growth and differentiation (reviewed in Hui and ...
  • Signaling events mediated by the Hedgehog family, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by the Hedgehog family, organism-specific biosystem
    Signaling events mediated by the Hedgehog family
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC111524

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell fate specification IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
embryonic body morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic retina morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
lens development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
myoblast fusion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of muscle cell differentiation TAS
Traceable Author Statement
more info
 
positive regulation of myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
regulation of protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle satellite cell differentiation IEA
Inferred from Electronic Annotation
more info
 
smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with extracellular matrix TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
cell adhesion molecule-related/down-regulated by oncogenes
Names
Cdon homolog
surface glycoprotein, Ig superfamily member

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029776.1 RefSeqGene

    Range
    5001..111475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243597.1NP_001230526.1  cell adhesion molecule-related/down-regulated by oncogenes isoform 1 precursor

    See identical proteins and their annotated locations for NP_001230526.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB209396, AP000842, BC098583, BC112362
    Consensus CDS
    CCDS58192.1
    UniProtKB/Swiss-Prot
    Q4KMG0
    Related
    ENSP00000376458, OTTHUMP00000231331, ENST00000392693, OTTHUMT00000386749
    Conserved Domains (6) summary
    cd00096
    Location:422514
    Ig; Immunoglobulin domain
    smart00408
    Location:326387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:141195
    IG_like; Immunoglobulin like
    cd00063
    Location:721811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:312398
    Ig; Immunoglobulin domain
  2. NM_016952.4NP_058648.4  cell adhesion molecule-related/down-regulated by oncogenes isoform 2 precursor

    See identical proteins and their annotated locations for NP_058648.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AF004841, AI190027, AP000842, BC112362
    Consensus CDS
    CCDS8468.1
    UniProtKB/Swiss-Prot
    Q4KMG0
    Related
    ENSP00000263577, OTTHUMP00000231332, ENST00000263577, OTTHUMT00000386750
    Conserved Domains (6) summary
    cd00096
    Location:422514
    Ig; Immunoglobulin domain
    smart00408
    Location:326387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:141195
    IG_like; Immunoglobulin like
    cd00063
    Location:721811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:312398
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    125956818..126063292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542866.1XP_011541168.1  

    See identical proteins and their annotated locations for XP_011541168.1

    UniProtKB/Swiss-Prot
    Q4KMG0
    Conserved Domains (6) summary
    cd00096
    Location:422514
    Ig; Immunoglobulin domain
    smart00408
    Location:326387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:141195
    IG_like; Immunoglobulin like
    cd00063
    Location:721811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:312398
    Ig; Immunoglobulin domain
  2. XM_011542862.1XP_011541164.1  

    See identical proteins and their annotated locations for XP_011541164.1

    UniProtKB/Swiss-Prot
    Q4KMG0
    Conserved Domains (6) summary
    cd00096
    Location:422514
    Ig; Immunoglobulin domain
    smart00408
    Location:326387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:141195
    IG_like; Immunoglobulin like
    cd00063
    Location:721811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:312398
    Ig; Immunoglobulin domain
  3. XM_011542864.1XP_011541166.1  

    See identical proteins and their annotated locations for XP_011541166.1

    UniProtKB/Swiss-Prot
    Q4KMG0
    Conserved Domains (6) summary
    cd00096
    Location:422514
    Ig; Immunoglobulin domain
    smart00408
    Location:326387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:141195
    IG_like; Immunoglobulin like
    cd00063
    Location:721811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:312398
    Ig; Immunoglobulin domain
  4. XM_011542865.1XP_011541167.1  

    See identical proteins and their annotated locations for XP_011541167.1

    UniProtKB/Swiss-Prot
    Q4KMG0
    Conserved Domains (6) summary
    cd00096
    Location:422514
    Ig; Immunoglobulin domain
    smart00408
    Location:326387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:141195
    IG_like; Immunoglobulin like
    cd00063
    Location:721811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:312398
    Ig; Immunoglobulin domain
  5. XM_011542863.1XP_011541165.1  

    See identical proteins and their annotated locations for XP_011541165.1

    UniProtKB/Swiss-Prot
    Q4KMG0
    Conserved Domains (6) summary
    cd00096
    Location:422514
    Ig; Immunoglobulin domain
    smart00408
    Location:326387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:141195
    IG_like; Immunoglobulin like
    cd00063
    Location:721811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:312398
    Ig; Immunoglobulin domain

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    125713444..125819847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)