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    SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 [ Homo sapiens ]

    Gene ID: 50859, updated on 5-Feb-2012
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    Summary

    Official Symbol
    SPOCK3provided by HGNC
    Official Full Name
    sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3provided by HGNC
    Primary source
    HGNC:13565
    Locus tag
    UNQ409/PRO771
    See related
    Ensembl:ENSG00000196104; HPRD:12147; MIM:607989; Vega:OTTHUMG00000161190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TES-3; TICN3; HSAJ1454
    Summary
    This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
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    Genomic context

    Location :
    4q32.3
    Sequence :
    Chromosome: 4; NC_000004.11 (167654535..168155741, complement)
    See SPOCK3 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing protein 38-like Neighboring gene tolloid-like 1 Neighboring gene annexin A10 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    2. Testican 3 expression in adult T-cell leukemia. Kamioka M, et al. Leuk Res, 2009 Jul. PMID 19144404.
    3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965.
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. High expression of testican 3 is associated with adult T-cell leukemia.
      Title: Testican 3 expression in adult T-cell leukemia.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9BQ16 P50281 MMP14    HPRD  PubMed  
    Q9BQ16 P08254 MMP3    HPRD  PubMed  
    Q9BQ16 Q92563 SPOCK2    HPRD  PubMed  
    BioGRID:119160 BioGRID:110466 MMP14    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119160 BioGRID:110458 MMP3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119160 BioGRID:115146 SPOCK2    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enzyme inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    glycosaminoglycan binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metalloendopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    metalloendopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    negative regulation of endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    testican-3
    Names
    testican-3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030414.1 RefSeqGene

      Range
      5001..506207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001040159.1 → NP_001035249.1  testican-3 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 2.
      Source sequence(s)
      AC020599, BC003017, BI603782
      Consensus CDS
      CCDS34095.1
      UniProtKB/Swiss-Prot
      Q9BQ16
      Related
      ENSP00000350153, OTTHUMP00000219858, ENST00000357545, OTTHUMT00000364096
      Conserved Domains (4) summary
      cd00104
      Location:139 – 180
      Blast Score: 114
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd00191
      Location:313 – 377
      Blast Score: 194
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:197 – 316
      Blast Score: 415
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:196 – 305
      Blast Score: 390
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    2. NM_001204352.1 → NP_001191281.1  testican-3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon, includes an alternate exon in the 5' coding region, and uses an alternate start codon, compared to variant 2. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AC020599, AK295015, BI603782
      Consensus CDS
      CCDS56344.1
      UniProtKB/TrEMBL
      B4DHB4
      Related
      ENSP00000411344, ENST00000421836
      Conserved Domains (4) summary
      cd00104
      Location:91 – 132
      Blast Score: 113
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd00191
      Location:265 – 329
      Blast Score: 193
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:149 – 268
      Blast Score: 415
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:148 – 257
      Blast Score: 391
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    3. NM_001204353.1 → NP_001191282.1  testican-3 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks two exons and uses a downstream, in-frame start codon, compared to variant 2. The encoded isoform (4) has a shorter N-terminus, compared to isoform 2.
      Source sequence(s)
      AC020599, AK295407
      Consensus CDS
      CCDS56343.1
      UniProtKB/TrEMBL
      B4DI46
      Related
      ENSP00000444789, ENST00000541354
      Conserved Domains (4) summary
      cd00104
      Location:22 – 63
      Blast Score: 112
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd00191
      Location:196 – 260
      Blast Score: 192
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:80 – 199
      Blast Score: 417
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:79 – 188
      Blast Score: 392
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    4. NM_001204354.1 → NP_001191283.1  testican-3 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two consecutive exons and uses a downstream, in-frame start codon, compared to variant 2. The encoded isoform (5) has a shorter N-terminus, compared to isoform 2.
      Source sequence(s)
      AC020599, AK091078, AK295414, BI603782
      UniProtKB/TrEMBL
      B4DI52
      UniProtKB/Swiss-Prot
      Q9BQ16
      Conserved Domains (4) summary
      cd00104
      Location:50 – 91
      Blast Score: 111
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd00191
      Location:224 – 288
      Blast Score: 191
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:108 – 227
      Blast Score: 415
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:107 – 216
      Blast Score: 391
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    5. NM_001204355.1 → NP_001191284.1  testican-3 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks three consecutive coding exons and uses an alternate start codon, compared to variant 2. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AC020599, AK295281, BI603782
      Consensus CDS
      CCDS56345.1
      UniProtKB/TrEMBL
      B4DHV3
      UniProtKB/TrEMBL
      F5H099
      Related
      ENSP00000438142, ENST00000534949
      Conserved Domains (4) summary
      cd00104
      Location:46 – 87
      Blast Score: 114
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd00191
      Location:220 – 284
      Blast Score: 195
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:104 – 223
      Blast Score: 421
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:103 – 212
      Blast Score: 395
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    6. NM_001204356.1 → NP_001191285.1  testican-3 isoform 7 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two alternate in-frame exons compared to variant 2. The resulting isoform (7) has the same N- and C-termini but is shorter compared to isoform 2.
      Source sequence(s)
      AC020599, AK296291, BI603782
      Consensus CDS
      CCDS56346.1
      UniProtKB/TrEMBL
      B4DJY3
      UniProtKB/TrEMBL
      E7EP61
      Related
      ENSP00000426716, OTTHUMP00000219865, ENST00000510741, OTTHUMT00000364103
      Conserved Domains (3) summary
      cd00104
      Location:139 – 180
      Blast Score: 112
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd00191
      Location:273 – 337
      Blast Score: 191
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:195 – 276
      Blast Score: 317
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...

    7. NM_001204358.1 → NP_001191287.1  testican-3 isoform 9 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (9, also known as N-TES) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 2.
      Source sequence(s)
      AB056866, AC020599, BI603782
      Consensus CDS
      CCDS56347.1
      UniProtKB/Swiss-Prot
      Q9BQ16
      Related
      ENSP00000426177, OTTHUMP00000219857, ENST00000512648, OTTHUMT00000364095
      Conserved Domains (3) summary
      cd00104
      Location:139 – 180
      Blast Score: 114
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd00252
      Location:197 – 311
      Blast Score: 390
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:196 – 305
      Blast Score: 385
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    8. NM_001251967.1 → NP_001238896.1  testican-3 isoform 11 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks four consecutive coding exons but maintains the reading frame, compared to variant 2. The encoded isoform (11) is shorter than isoform 2.
      Source sequence(s)
      AC020599, AK294637, BI603782
      UniProtKB/TrEMBL
      B4DGK5
      Conserved Domains (3) summary
      cd00191
      Location:218 – 282
      Blast Score: 196
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:102 – 221
      Blast Score: 414
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:101 – 210
      Blast Score: 389
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    9. NM_016950.2 → NP_058646.2  testican-3 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AC020599, AY358973, BI603782
      Consensus CDS
      CCDS54817.1
      UniProtKB/Swiss-Prot
      Q9BQ16
      Related
      ENSP00000349677, OTTHUMP00000219853, ENST00000357154, OTTHUMT00000364091
      Conserved Domains (4) summary
      cd00104
      Location:142 – 183
      Blast Score: 114
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd00191
      Location:316 – 380
      Blast Score: 194
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:200 – 319
      Blast Score: 414
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:199 – 308
      Blast Score: 390
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      167654535..168155741, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      163410545..163907393, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

     

    1. NM_001204359.1: Suppressed sequence

      Description
      NM_001204359.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC010103.10 (1999..192037) None
    genomic AC020599.4 (2000..128064) None
    genomic AC023492.5 AAY40993.1
    genomic AC107210.5 AAY40960.1
    genomic CH471056.2 EAX04811.1
      EAX04812.1
    mRNA AB056866.1 BAB64908.1
    mRNA AJ001454.1 CAA04775.1
    mRNA AK091078.1 BAG52279.1
    mRNA AK294293.1 BAG57576.1
    mRNA AK294346.1 BAG57615.1
    mRNA AK294637.1 BAG57816.1
    mRNA AK295015.1 BAG58075.1
    mRNA AK295281.1 BAG58265.1
    mRNA AK295407.1 BAG58358.1
    mRNA AK295414.1 BAG58364.1
    mRNA AK296291.1 BAG58995.1
    mRNA AK313042.1 BAG35874.1
    mRNA AY358973.1 AAQ89332.1
    mRNA BC000460.2 AAH00460.1
    mRNA BC003017.1 AAH03017.1
    mRNA BC013983.2 AAH13983.1
    mRNA BI603782.1 None
    mRNA DN989433.1 None
    other-genetic HQ447688.1 ADQ32173.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q4W5E2 GenPept UniProtKB/TrEMBL:Q4W5E2
    Q4W5S3 GenPept UniProtKB/TrEMBL:Q4W5S3
    Q9BQ16.2 GenPept UniProtKB/Swiss-Prot:Q9BQ16
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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