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COPS7A COP9 signalosome subunit 7A [ Homo sapiens (human) ]

Gene ID: 50813, updated on 26-May-2016
Official Symbol
COPS7Aprovided by HGNC
Official Full Name
COP9 signalosome subunit 7Aprovided by HGNC
Primary source
HGNC:HGNC:16758
See related
Ensembl:ENSG00000111652 HPRD:16736; MIM:616009; Vega:OTTHUMG00000169182
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSN7; CSN7A; SGN7a
Summary
This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014]
Orthologs
Location:
12p13.31
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (6723984..6731875)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6833150..6841041)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 384 Neighboring gene PILR alpha associated neural protein Neighboring gene myeloid leukemia factor 2 Neighboring gene parathymosin

  • DNA Damage Recognition in GG-NER, organism-specific biosystem (from REACTOME)
    DNA Damage Recognition in GG-NER, organism-specific biosystemIn global genome nucleotide excision repair (GG-NER), the DNA damage is recognized by two protein complexes. The first complex consists of XPC, RAD23A or RAD23B, and CETN2. This complex probes the DN...
  • DNA Repair, organism-specific biosystem (from REACTOME)
    DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
  • Formation of TC-NER Pre-Incision Complex, organism-specific biosystem (from REACTOME)
    Formation of TC-NER Pre-Incision Complex, organism-specific biosystemFormation of TC-NER pre-incision complex is initiated when the RNA polymerase II (RNA Pol II) complex stalls at a DNA damage site. The stalling is caused by misincorporation of a ribonucleotide oppos...
  • Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystem (from REACTOME)
    Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystemThe DNA damage in GG-NER is recognized by the joint action of two protein complexes. The first complex is composed of XPC, RAD23A or RAD23B and CETN2. The second complex, known as the UV-DDB complex,...
  • Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
    Nucleotide Excision Repair, organism-specific biosystemNucleotide excision repair (NER) was first described in the model organism E. coli in the early 1960s as a process whereby bulky base damage is enzymatically removed from DNA, facilitating the recove...
  • Transcription-Coupled Nucleotide Excision Repair (TC-NER), organism-specific biosystem (from REACTOME)
    Transcription-Coupled Nucleotide Excision Repair (TC-NER), organism-specific biosystemDNA damage in transcribed strands of active genes is repaired through a specialized nucleotide excision repair (NER) pathway known as transcription-coupled nucleotide excision repair (TC-NER). TC-NER...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC110877

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cullin deneddylation IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide-excision repair, DNA damage recognition TAS
Traceable Author Statement
more info
 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
Preferred Names
COP9 signalosome complex subunit 7a
Names
COP9 complex subunit 7a
COP9 constitutive photomorphogenic homolog subunit 7A
JAB1-containing signalosome subunit 7a
dermal papilla-derived protein 10

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034023.1 RefSeqGene

    Range
    5001..12892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164093.1NP_001157565.1  COP9 signalosome complex subunit 7a

    See identical proteins and their annotated locations for NP_001157565.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK292621, BC011789, BQ008460, DC355036
    Consensus CDS
    CCDS8558.1
    UniProtKB/Swiss-Prot
    Q9UBW8
    Related
    ENSP00000446039, OTTHUMP00000240342, ENST00000534947, OTTHUMT00000402757
    Conserved Domains (1) summary
    pfam01399
    Location:64155
    PCI; PCI domain
  2. NM_001164094.1NP_001157566.1  COP9 signalosome complex subunit 7a

    See identical proteins and their annotated locations for NP_001157566.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    BC011789, BQ008460, DA043679
    Consensus CDS
    CCDS8558.1
    UniProtKB/Swiss-Prot
    Q9UBW8
    Related
    ENSP00000438115, OTTHUMP00000240328, ENST00000543155, OTTHUMT00000402740
    Conserved Domains (1) summary
    pfam01399
    Location:64155
    PCI; PCI domain
  3. NM_001164095.2NP_001157567.1  COP9 signalosome complex subunit 7a

    See identical proteins and their annotated locations for NP_001157567.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AB014764, AC125494, BC011789, BQ008460, HY087807
    Consensus CDS
    CCDS8558.1
    UniProtKB/Swiss-Prot
    Q9UBW8
    Related
    ENSP00000441852, OTTHUMP00000240333, ENST00000539735, OTTHUMT00000402748
    Conserved Domains (1) summary
    pfam01399
    Location:64155
    PCI; PCI domain
  4. NM_016319.3NP_057403.1  COP9 signalosome complex subunit 7a

    See identical proteins and their annotated locations for NP_057403.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC125494, AF210052, BC011789, BQ008460
    Consensus CDS
    CCDS8558.1
    UniProtKB/Swiss-Prot
    Q9UBW8
    Related
    ENSP00000229251, OTTHUMP00000240332, ENST00000229251, OTTHUMT00000402747
    Conserved Domains (1) summary
    pfam01399
    Location:64155
    PCI; PCI domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    6723984..6731875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253695.1XP_005253752.1  

    See identical proteins and their annotated locations for XP_005253752.1

    UniProtKB/Swiss-Prot
    Q9UBW8
    Related
    ENSP00000438363, OTTHUMP00000240345, ENST00000534877, OTTHUMT00000402762
    Conserved Domains (1) summary
    pfam01399
    Location:64155
    PCI; PCI domain
  2. XM_005253694.1XP_005253751.1  

    See identical proteins and their annotated locations for XP_005253751.1

    UniProtKB/Swiss-Prot
    Q9UBW8
    Conserved Domains (1) summary
    pfam01399
    Location:64155
    PCI; PCI domain

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    6832136..6840030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)