HP1BP3 heterochromatin protein 1, binding protein 3 [Homo sapiens] - Gene

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Summary

Official Symbol: HP1BP3provided by HGNC
Official Full Name: heterochromatin protein 1, binding protein 3provided by HGNC
Primary source: HGNC:24973
Locus tag: RP5-930J4.3
See related: Ensembl:ENSG00000127483; HPRD:11026; Vega:OTTHUMG00000002622
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HP1-BP74; RP5-930J4.3; MGC43701

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Genomic context

Location :: 1p36.12

Sequence :: Chromosome: 1; NC_000001.10 (21069171..21113181, complement)

See HP1BP3 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
HP1-BP74 directly binds to HP1, and its middle region associates with linker DNA at the entry/exit site of nucleosomal DNA in vitro
Title: The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA.
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Title: Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:119128	BioGRID:109318	HDGF	BioGRID	PubMed	Affinity Capture-MS
BioGRID:119128	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:119128	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:119128	BioGRID:1205541	tat	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
nucleosome assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
chromosome	IEA Inferred from Electronic Annotation more info
nucleosome	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: heterochromatin protein 1-binding protein 3

Names: heterochromatin protein 1-binding protein 3; HP1-BP74

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016287.3 → NP_057371.2 heterochromatin protein 1-binding protein 3

Status: VALIDATED

Source sequence(s)

AK023129, AK025754

Consensus CDS

CCDS30621.1

UniProtKB/Swiss-Prot

Q5SSJ5

Related

ENSP00000312625, OTTHUMP00000002716, ENST00000312239, OTTHUMT00000007457

Conserved Domains (2) summary

cd00073
Location:155 – 242
Blast Score: 191

H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...

cl00073
Location:253 – 319
Blast Score: 134

H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

21069171..21113181, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

19314898..19359180, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL606477.11	CAI12528.1
		CAI12529.1
		CAI12530.1
		CAI12531.1
		CAI12532.1
		CAI12533.1
		CAQ10949.1
		CAQ10950.1
		CAQ10951.1
		CAQ10952.1
		CAQ10953.1
genomic	AL663074.13	CAI23387.1
		CAI23388.1
		CAI23389.1
genomic	CH471134.1	EAW94950.1
		EAW94951.1
		EAW94952.1
		EAW94953.1
mRNA	AF113534.1	AAF14871.1
mRNA	AK023129.1	BAG51160.1
mRNA	AK025754.1	None
mRNA	AK291252.1	BAF83941.1
mRNA	AK303456.1	BAG64500.1
mRNA	AK304065.1	BAG64972.1
mRNA	AL833978.1	CAD38822.1
mRNA	BC032139.2	AAH32139.1
mRNA	BC045660.1	AAH45660.1
mRNA	BC046170.1	None
mRNA	BC053327.1	None
mRNA	BE247224.1	None
mRNA	BM312215.1	None
mRNA	CK000759.1	None
other-genetic	EU832526.1	ACE87698.1