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MYEF2 myelin expression factor 2 [ Homo sapiens (human) ]

Gene ID: 50804, updated on 26-May-2016
Official Symbol
MYEF2provided by HGNC
Official Full Name
myelin expression factor 2provided by HGNC
Primary source
HGNC:HGNC:17940
See related
Ensembl:ENSG00000104177 HPRD:14794; Vega:OTTHUMG00000172120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEF-2; MST156; myEF-2; MSTP156; HsT18564
Orthologs
Location:
15q21.1
Exon count:
19
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (48139428..48178400, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (48431629..48470714, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1491 Neighboring gene uncharacterized LOC105370805 Neighboring gene uncharacterized LOC102724553 Neighboring gene solute carrier family 24 member 5 Neighboring gene uncharacterized LOC105370807 Neighboring gene cortexin 2 Neighboring gene uncharacterized LOC105370806 Neighboring gene solute carrier family 12 member 1

Replication interactions

Interaction Pubs
Knockdown of myelin expression factor 2 (MYEF2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ11213, KIAA1341, MGC87325

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
myotube differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
neuron differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
myelin expression factor 2
Names
myelin gene expression factor 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301210.1NP_001288139.1  myelin expression factor 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AB037762, AF190159, AK023133, AW023574, BC014533, BX647197, CN358153
    Consensus CDS
    CCDS73722.1
    UniProtKB/Swiss-Prot
    Q9P2K5
    Related
    ENSP00000267836, OTTHUMP00000247714, ENST00000267836, OTTHUMT00000416979
    Conserved Domains (4) summary
    smart00360
    Location:501570
    RRM; RNA recognition motif
    cd12386
    Location:235308
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:101176
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:500576
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
  2. NM_016132.4NP_057216.2  myelin expression factor 2 isoform a

    See identical proteins and their annotated locations for NP_057216.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AB037762, AW023574, BX647197, DA680322
    Consensus CDS
    CCDS32230.1
    UniProtKB/Swiss-Prot
    Q9P2K5
    Related
    ENSP00000316950, OTTHUMP00000247672, ENST00000324324, OTTHUMT00000416909
    Conserved Domains (4) summary
    smart00360
    Location:525594
    RRM; RNA recognition motif
    cd12386
    Location:235308
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:101176
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:524600
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)

RNA

  1. NR_125408.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' region, and also lacks several 3' exons but includes an alternate 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AW964493, BC068523, DA680322
    Related
    ENST00000561351, OTTHUMT00000416985

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

    Range
    48139428..48178400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254424.3XP_005254481.2  

    Conserved Domains (4) summary
    smart00360
    Location:484553
    RRM; RNA recognition motif
    cd12386
    Location:235308
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:101176
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:483559
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
  2. XM_005254422.3XP_005254479.2  

    Conserved Domains (4) summary
    smart00360
    Location:508577
    RRM; RNA recognition motif
    cd12386
    Location:235308
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:101176
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:507583
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
  3. XM_005254425.3XP_005254482.2  

    Conserved Domains (3) summary
    smart00360
    Location:101173
    RRM; RNA recognition motif
    cd12386
    Location:235308
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:101176
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
  4. XM_006720553.2XP_006720616.1  

    See identical proteins and their annotated locations for XP_006720616.1

    UniProtKB/TrEMBL
    A0A024R5Q6
    Conserved Domains (4) summary
    smart00360
    Location:365434
    RRM; RNA recognition motif
    cd12386
    Location:75148
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12662
    Location:364440
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
    cl17169
    Location:116
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. XM_011521657.1XP_011519959.1  

    Conserved Domains (3) summary
    smart00360
    Location:361430
    RRM; RNA recognition motif
    cd12386
    Location:71144
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12662
    Location:360436
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
  6. XM_005254427.3XP_005254484.1  

    Conserved Domains (3) summary
    smart00360
    Location:101173
    RRM; RNA recognition motif
    cd12386
    Location:235308
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:101176
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    48549817..48588754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)