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KCNK4 potassium two pore domain channel subfamily K member 4 [ Homo sapiens (human) ]

Gene ID: 50801, updated on 26-May-2016
Official Symbol
KCNK4provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 4provided by HGNC
Primary source
HGNC:HGNC:6279
See related
Ensembl:ENSG00000182450 HPRD:12037; MIM:605720; Vega:OTTHUMG00000168006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRAAK; K2p4.1; TRAAK1
Summary
This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015]
Orthologs
Location:
11q13
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (64291321..64300031)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64058774..64067503)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927696 Neighboring gene phospholipase C beta 3 Neighboring gene G protein-coupled receptor 137 Neighboring gene BCL2 associated agonist of cell death Neighboring gene testis expressed 40 Neighboring gene estrogen related receptor alpha Neighboring gene tRNA methyltransferase 11-2 homolog (S. cerevisiae)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1.
NHGRI GWA Catalog
  • Cardiac conduction, organism-specific biosystem (from REACTOME)
    Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Phase 4 - resting membrane potential, organism-specific biosystem (from REACTOME)
    Phase 4 - resting membrane potential, organism-specific biosystemPhase 4 describes the membrane potential when a cell is not being stimulated. The normal resting potential in the ventricular myocardium is between -85 to -95 mV. The membrane is most permeable to K+...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • TWIK related potassium channel (TREK), organism-specific biosystem (from REACTOME)
    TWIK related potassium channel (TREK), organism-specific biosystemTREK1 and TREK 2 are activated by physiochemical changes like stretch, convex deformation of the plasma membrane, depolarization, heat and intracellular acidosis. Polyunsaturated fatty acids (PUFA) i...
  • Tandem pore domain potassium channels, organism-specific biosystem (from REACTOME)
    Tandem pore domain potassium channels, organism-specific biosystemTandem pore domain K+ channels (K2p) produce leak K+ current which stabilizes negative membrane potential and counter balances depolarization. These channels are regulated by voltage independent mech...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough KCNK4-TEX40

Readthrough gene: KCNK4-TEX40, Included gene: TEX40

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mechanically-gated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
temperature-gated cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to alkaline pH ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to fatty acid IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to mechanical stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to temperature stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
detection of mechanical stimulus involved in sensory perception of touch ISS
Inferred from Sequence or Structural Similarity
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
sensory perception of temperature stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
potassium channel subfamily K member 4
Names
K2P4.1 potassium channel
TWIK-related arachidonic acid-stimulated potassium channel protein
potassium channel, subfamily K, member 4
potassium channel, two pore domain subfamily K, member 4
two pore K(+) channel KT4.1
two pore K+ channel KT4.1
two pore potassium channel KT4.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317090.1NP_001304019.1  potassium channel subfamily K member 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 2. Both variants 2 and 4 encode the same protein.
    Source sequence(s)
    AP001453, BC110327
    UniProtKB/Swiss-Prot
    Q9NYG8
    UniProtKB/TrEMBL
    A0A024R5C7, Q2YDA1
    Conserved Domains (1) summary
    pfam07885
    Location:88139
    Ion_trans_2; Ion channel
  2. NM_033310.2NP_201567.1  potassium channel subfamily K member 4 precursor

    See identical proteins and their annotated locations for NP_201567.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the functional protein.
    Source sequence(s)
    AF259500, AP001453, BC067791, BC110327, DB273064
    Consensus CDS
    CCDS8067.1
    UniProtKB/Swiss-Prot
    Q9NYG8
    UniProtKB/TrEMBL
    A0A024R5C7, Q2YDA1
    Related
    ENSP00000402797, OTTHUMP00000236953, ENST00000422670, OTTHUMT00000396426
    Conserved Domains (1) summary
    pfam07885
    Location:88139
    Ion_trans_2; Ion channel

RNA

  1. NR_133660.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' most exon, lacks an internal exon and uses an alternate splice site in an internal exon compared to variant 2. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AP001453, BC067791
  2. NR_133661.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' most exon and uses an alternate splice site in an internal exon compared to variant 2. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AP001453, BC033577

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    64291321..64300031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    63941791..63950504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016611.2: Suppressed sequence

    Description
    NM_016611.2: This RefSeq was permanently suppressed because it is a rare readthrough transcript.