Format

Send to:

Choose Destination

Dlc1 deleted in liver cancer 1 [ Mus musculus (house mouse) ]

Gene ID: 50768, updated on 8-May-2016
Official Symbol
Dlc1provided by MGI
Official Full Name
deleted in liver cancer 1provided by MGI
Primary source
MGI:MGI:1354949
See related
Ensembl:ENSMUSG00000031523 Vega:OTTMUSG00000028535
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HP; dlc-1; Arhgap7; STARD12; A730069N07Rik
Orthologs
Location:
8 23.05 cM; 8 A4-B2
Exon count:
27
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (36567739..36953165, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (37630799..37676928, complement)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6430573F11 gene Neighboring gene ubiquitin-conjugating enzyme E2E 1, UBC4/5 homolog pseudogene Neighboring gene predicted gene, 35802 Neighboring gene RIKEN cDNA G630064G18 gene Neighboring gene predicted gene, 39166 Neighboring gene expressed sequence AI429214

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ21120

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase binding ISO
Inferred from Sequence Orthology
more info
 
vinculin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
activation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hindbrain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with actin filament ISO
Inferred from Sequence Orthology
more info
 
caveola ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with focal adhesion ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
ruffle membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with stress fiber ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
rho GTPase-activating protein 7
Names
START domain-containing protein 12
p122-RhoGAP
rho-type GTPase-activating protein 7
stAR-related lipid transfer protein 12

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001194940.2NP_001181869.1  rho GTPase-activating protein 7 isoform 1

    See identical proteins and their annotated locations for NP_001181869.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC138593, AC158349, AC168051, BE199599, HM008381
    Consensus CDS
    CCDS57617.1
    UniProtKB/TrEMBL
    D5M8I5, E9PXD2
    Related
    ENSMUSP00000132812, OTTMUSP00000050896, ENSMUST00000163663, OTTMUST00000092190
    Conserved Domains (4) summary
    cd09591
    Location:468527
    SAM_DLC1; SAM domain of DLC1 subfamily
    smart00454
    Location:468527
    SAM; Sterile alpha motif
    cd04375
    Location:10871305
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    cl14643
    Location:13301533
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  2. NM_001194941.1NP_001181870.1  rho GTPase-activating protein 7 isoform 3

    See identical proteins and their annotated locations for NP_001181870.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC103378, AK147539, BE199599
    Consensus CDS
    CCDS57616.1
    UniProtKB/Swiss-Prot
    Q9R0Z9
    UniProtKB/TrEMBL
    A0A0R4J171
    Related
    ENSMUSP00000096425, OTTMUSP00000036077, ENSMUST00000098826, OTTMUST00000070713
    Conserved Domains (4) summary
    cd09591
    Location:51110
    SAM_DLC1; SAM domain of DLC1 subfamily
    smart00454
    Location:51110
    SAM; Sterile alpha motif
    cd04375
    Location:670888
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    cl14643
    Location:9131116
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  3. NM_015802.3NP_056617.2  rho GTPase-activating protein 7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC138593, AK147539, AK162413, BE199599
    Consensus CDS
    CCDS40322.1
    UniProtKB/Swiss-Prot
    Q9R0Z9
    UniProtKB/TrEMBL
    E9QKB1
    Related
    ENSMUSP00000033923, OTTMUSP00000036078, ENSMUST00000033923, OTTMUST00000070714
    Conserved Domains (4) summary
    cd09591
    Location:1776
    SAM_DLC1; SAM domain of DLC1 subfamily
    smart00454
    Location:1776
    SAM; Sterile alpha motif
    cd04375
    Location:636854
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    cl14643
    Location:8791082
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

    Range
    36567739..36953165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509166.2XP_006509229.1  

    See identical proteins and their annotated locations for XP_006509229.1

    UniProtKB/TrEMBL
    E9PXD2
    Conserved Domains (4) summary
    cd09591
    Location:468527
    SAM_DLC1; SAM domain of DLC1 subfamily
    smart00454
    Location:468527
    SAM; Sterile alpha motif
    cd04375
    Location:10871305
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    cl14643
    Location:13301533
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  2. XM_011242152.1XP_011240454.1  

  3. XM_011242151.1XP_011240453.1  

  4. XM_006509167.2XP_006509230.1  

  5. XM_011242153.1XP_011240455.1  

  6. XM_006509168.2XP_006509231.1  

  7. XM_006509169.2XP_006509232.1  

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    39196109..39592727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178735.3: Suppressed sequence

    Description
    NM_178735.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript retains intronic sequence at its 3' end.